Opioids for acute pancreatitis pain

Ona, Xavier Basurto; Comas, David Rigau; Urrútia, Gerard

doi:10.1002/14651858.cd009179

Cited by 24 publications

(33 citation statements)

References 9 publications

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“…However, as acute gastrointestinal syndromes in humans are almost always characterized by abdominal tenderness and pain (Onder et al 2013;Wilkins et al 2013;AlFraih et al 2014), veterinarians who participated in this survey might believe that the same is true in dogs, thus explaining the high percentage of responses. In humans, pancreatitis is known to be extremely painful (Fregni et al 2007;Basurto Ona et al 2013). It is also a potentially life-threatening disease in the veterinary clinical setting, and this explains the high number of responses mentioning this condition.…”

Section: Discussionmentioning

confidence: 99%

Preliminary study on attitudes, opinions and knowledge of Italian veterinarians with regard to abdominal visceral pain in dogs

Catanzaro

Salvo

Steagall

et al. 2016

Veterinary Anaesthesia and Analgesia

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Section: Discussionmentioning

confidence: 99%

Preliminary study on attitudes, opinions and knowledge of Italian veterinarians with regard to abdominal visceral pain in dogs

Catanzaro

Salvo

Steagall

et al. 2016

Veterinary Anaesthesia and Analgesia

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“…Numerous RCTs compared the effects of different kinds of analgesia in AP (Blamey et al, ; Jakobs et al, ; Stevens, Esler and Asher, ; Kahl et al, ; Peiró et al, ; Wilms, Meffert and Schultes, ; Layer et al, ). A recent meta‐analysis report indicated that opioid use in AP and most RCTs are of low quality and do not have specific analgesic strategies (Basurto Ona, Rigau Comas and Urrútia, ). Because the recent evidence is inadequate, pain can be treated with the most advanced pain protocol.…”

Section: Pain Managementmentioning

confidence: 99%

Current status of diagnosis and Mesenchymal stem cells therapy for acute pancreatitis

et al. 2019

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Acute pancreatitis (AP) is an acute gastrointestinal disorder that is the most common and requiring emergency hospitalization. Its incidence is increasing worldwide, thus increasing the burden of medical services. Approximately 20% of the patients develop moderate to severe necrotizing pancreatitis associated with pancreatic or peri‐pancreatic tissue necrosis and multiple organ failure. There are many reports about the anti‐inflammatory effect of mesenchymal stem cells (MSCs) on pancreatitis and the repair of tissue damage. MSCs cells come from a wide range of sources, autologous MSCs come from bone marrow and allogeneic MSCs such as umbilical cord blood MSCs, placenta‐derived MSCs, etc. The wide source is not only an advantage of MSCs but also a disadvantage of MSCs. Because of different cell sources and different methods of collection and preparation, it is impossible to establish a unified standard method for evaluation of efficacy. The biggest advantage of iMSCs is that it can be prepared by a standardized process, and can be prepared on a large scale, which makes it easier to commercialize. This paper reviews the present status of diagnosis and progress of MSCs therapy for AP.

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“…Therefore, aggressive control of pain can help to improve the quality of life and reduce the severity of pancreatitis in patients with AP, regardless of etiology. An effective treatment of pain in AP ranges from the administration of simple analgesic drugs, such as non-steroidal anti-inflammatory drugs, up to the administrations of potent opioid drugs according to the severity [ 4 , 21 ]. However, the adequate treatment of pain is much more complex in clinical circumstances.…”

Section: Discussionmentioning

confidence: 99%

“…Opioids are safe and effective for pain control in patients with AP. Compared with other analgesic options, opioids may decrease the need for supplementary analgesia [ 4 ]. However, frequent administration of opioid analgesics may result in opioid dependency [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Electroacupuncture for abdominal pain relief in patients with acute pancreatitis: study protocol for a randomized controlled trial

Jang

Jung

Kim

2018

Trials

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BackgroundPrevious studies have shown that electroacupuncture (EA) reduces the severity of acute pancreatitis. However, the effect of EA for pain relief in patients with acute pancreatitis has not been evaluated yet. The purpose of this study was to prove the efficacy of EA for pain relief in patients with acute pancreatitis compared with conventional treatment.MethodsThis study is a randomized, controlled, three-arm, parallel-group, multi-center trial. Patients diagnosed with acute pancreatitis are enrolled and randomly assigned to EA 1, EA 2, or a control group in a 1:1:1 ratio. All the enrolled patients basically receive the conventional standard-of-care therapy for acute pancreatitis. Local EA is given in group EA 1, while local with additional distal EA is given in group EA 2. Local EA includes two acupoints, Zhong Wan (CV12) and Shang Wan (CV13), located in the abdomen, while distal EA includes 12 peripheral acupoints, Zhong Wan (CV12), Shang Wan (CV13), He Gu (LI4), Nei Guan (PC6), San Yin Jiao (SP6), Xuan Zhong (GB39), Zu San Li (ST36), and Shang Ju Xu (ST37). The patients randomized to the EA 1 and EA 2 groups undergo one session of EA daily from day 1 until day 4, or until pain resolves. The primary endpoint is the Visual Analog Scale (VAS) change for pain on day 5. Secondary endpoints include daily VAS, requirement of analgesics, changes of inflammatory markers, time to pain disappearance, and hospital days.DiscussionThe results of this trial are expected to prove the efficacy of EA for pain relief in patients with acute pancreatitis. Based upon the results, EA would be applied to a variety of clinical practices for reducing pain.Trial registrationThis trial is registered at ClinicalTrials.gov, ID: NCT03173222. Registered on 1 August 2017.Electronic supplementary materialThe online version of this article (10.1186/s13063-018-2644-1) contains supplementary material, which is available to authorized users.

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Opioids for acute pancreatitis pain

Cited by 24 publications

References 9 publications

Preliminary study on attitudes, opinions and knowledge of Italian veterinarians with regard to abdominal visceral pain in dogs

Preliminary study on attitudes, opinions and knowledge of Italian veterinarians with regard to abdominal visceral pain in dogs

Current status of diagnosis and Mesenchymal stem cells therapy for acute pancreatitis

Electroacupuncture for abdominal pain relief in patients with acute pancreatitis: study protocol for a randomized controlled trial

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