Opioids and their proper use as analgesics in the management of head and neck cancer patients

Thompson, A. Reed

doi:10.1053/ajot.2000.0210244

Cited by 14 publications

(30 citation statements)

References 17 publications

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“…This perceived lack of support and understanding of Miles' unique experience of illness made the difficult transition from the illusion of health to the uncertainty of life after SCCHN all the more difficult [23,24,25,26,27,28,29,30,31,32,33,34,35,36,37].…”

Section: Resultsmentioning

confidence: 99%

“…An increasing number of studies focus on the quality of life (QOL) of SCCHN patients [3,15,17,18,19,24,25,26,27,28,29,30,31,32,33,34,35,38,39,40,41,42]. QOL is multifactorial and subjective, and improvement in cancer-related symptoms can be achieved through primary assessment and intervention for problems as they arise [15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35].…”

Section: Methodsmentioning

confidence: 99%

“…QOL is multifactorial and subjective, and improvement in cancer-related symptoms can be achieved through primary assessment and intervention for problems as they arise [15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35]. For example, the initial measurement of pain after treatment is more likely to predict pain status contributing to a decrease in the overall QOL after primary-stage SCCHN [3,15,17,18,19,24,25,26,27,28,29,30,31,32,33,34,35,38,39,40,41,42]. While such issues are clearly relevant, no studies have used qualitative methods to elucidate factors associated with the under-reporting of suffering in individuals in this patient population.…”

Section: Methodsmentioning

confidence: 99%

“…While opioid analgesics play an important part in the interdisciplinary management of SCCHN patients, many cancer patients, as well as clinicians, fail to manage cancer pain well because of needless fears of addiction to the opioids, opioid toxicity, or substance abuse in this particular patient population [1,2,3,4,5,6,26,27,34,38]. Other patients refuse pain medicine in an attempt to broaden the scope of personal and social control in an outof-control situation.…”

Section: Fears Of Cancer Fears Of Addictionmentioning

confidence: 99%

“…These include: (1) late presentation of disease [3,4,9,10]; (2) treatments for cure that still cause significant psychological and physical morbidity after curative treatment(s) [15,16,17,18,19,20,21]; (3) the continued consumption of alcohol and tobacco after the diagnosis and during treatment [1,2,3]; and (4) the occurrence of high-mortality second primary tumors, which arise at a rate of 1-4% per year. The last of these remains one of the more significant challenges to effective treatment in the long term, as the overall survival rates for SCCHN have not radically improved since the 1970s [3,15,16,22,23,24,25,26,27,28]. In addition, pain remains a common symptom in SCCHN patients and suffering has been underevaluated in patients with primary stage SCCHN [15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,…”

Section: Introductionmentioning

confidence: 99%

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A qualitative study of head and neck cancer

Moore

Chamberlain

Khuri

2004

Supportive Care in Cancer

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The findings presented contribute to quality of life (QOL) research by highlighting the significance of factors affecting the communication by patients with primary-stage squamous cell carcinoma of the head and neck cancer (SCCHN) of their experiences of suffering after treatment to their clinicians. Qualitative research methodology based on open-ended interviews with 18 survivors of American Joint Committee on Cancer primary stage I and II SCCHN were used. The interviews were transcribed verbatim and thematically analyzed. Three important themes emerged: (1). a diminished self (2). fears of addiction, and (3). hopelessness and the loss of meaning in life after SCCHN. The findings indicate that SCCHN patients under-report their experiences mainly due to fear. As a consequence, and perhaps due to a failure on the part of clinicians and patients to adequately address such fears, SCCHN patients may experience greater psychological morbidity, becoming increasingly fatalistic about biomedicine's ability to restore them to health after cancer despite being "cured", or to relieve related symptoms. This qualitative study provides a perspective as to why such under-reporting occurs, thereby potentially enhancing clinician-patient communication and the QOL of SCCHN patients who present with curable disease.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Fears Of Cancer Fears Of Addictionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A qualitative study of head and neck cancer

Moore

Chamberlain

Khuri

2004

Supportive Care in Cancer

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The Effect of Postoperative Naloxone in Certain Otolaryngologic Surgeries

Perlov,

Shah,

Bluj

et al. 2023

Otolaryngol.--head neck surg.

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ObjectiveTo evaluate the association of postoperative naloxone with the development of new substance use disorder (SUD), overdose, and death within 6 months of otolaryngologic surgery.Study DesignRetrospective cohort database study on TriNetX.MethodsAdult patients who underwent tonsil surgery (noncancerous), thyroid/parathyroid, septorhinoplasty, otology/neurotology, sinus/anterior skull base, and head and neck cancer surgeries between January 2003 and April 2023. Patients were excluded if they had an instance of SUD or overdose recorded in their charts prior to surgery, or had undergone another surgery within that 6‐month time frame. We hypothesized that patients prescribed naloxone postoperatively would have decreased odds for experiencing new SUD, overdose, and/or death within 6 months of surgery compared to patients who did not receive naloxone. P < .01 was considered statistically significant.ResultsThere were 2,305,655 patients in this study. The average age was 36.7 ± 19.5 years old, with 46% female patients. Before matching, cohorts showed equivocal odds for developing new SUD, increased odds for overdose, and mixed odds for dying. After matching for demographic variables and comorbidities such as other substance use, opioid use for other pathologies, and psychiatric conditions, these effects diminished (P > .01).ConclusionOur results suggest that postoperative naloxone may not significantly affect development of new SUD and incident overdose and death in certain otolaryngologic surgeries after controlling for prior SUD and psychiatric conditions. Clinicians should be aware of these comorbidities when considering their postoperative pain management protocol, which may or may not include naloxone.

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Palliation of Head and Neck Cancer

Davis

Current Clinical Oncology

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Opioids and their proper use as analgesics in the management of head and neck cancer patients

Cited by 14 publications

References 17 publications

A qualitative study of head and neck cancer

A qualitative study of head and neck cancer

The Effect of Postoperative Naloxone in Certain Otolaryngologic Surgeries

Palliation of Head and Neck Cancer

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