Opioid substitution treatment reduces substance use equivalently in patients with and without posttraumatic stress disorder.

Comparison of treatment outcomes for Veterans with posttraumatic stress disorder with and without comorbid substance use/dependence

“…Of particular interest is the effect that comorbidity has on the outcomes of treatment. Most research has focused on the effects of comorbid PTSD on SUD outcomes and has generally found that the presence of PTSD is associated with worse SUD outcomes, apparently rendering SUD treatment less effective than when PTSD is absent (e.g., Mills et al, 2005;Najavits et al, 2007;Ouimette et al, 1998Ouimette et al, , 1999, although exceptions have been reported (e.g., Trafton et al, 2006). Relatively little attention has been paid, however, to the effect of comorbid SUD on PTSD outcomes.…”

Complex Comorbidity of Substance Use Disorders with Anxiety Disorders: Diagnosis and Treatment

“…In a prospective observational study, opioid replacement therapy was found to be efective at reducing substance use in patients with opioid dependence and PTSD. However, patients with comorbidity received higher doses of opioid medication and atended more psychosocial treatment sessions when compared to SUD-only group [71].…”

Posttraumatic Stress Disorders and Addiction

“…In one study, Trafton et al (2006) assessed the effects of opioid substitution therapy among 255 opioid-dependent veterans. In this prospective observational trial, substitution therapy was as effective at reducing substance use in patients with comorbid PTSD as it was in patients without the disorder.…”