Opioid Receptor Signaling and Regulation

Law, P‐Y; Loh, Horace H.

doi:10.1007/978-0-387-30381-9_18

Cited by 2 publications

(1 citation statement)

References 326 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Naturally-occuring alkaloids isolated from Papaver somniferum have a long history of use in pain management [34–35], and numerous classes of structural analogs have been produced that exhibit unique pharmacology (Fig. 2 ) [36].…”

Section: Opioid Receptor Ligandsmentioning

confidence: 99%

Cholinergic Modulation by Opioid Receptor Ligands: Potential Application to Alzheimer's Disease

Motel¹,

Coop²,

Cunningham³

2013

Mini Reviews in Medicinal Chemistry

View full text Add to dashboard Cite

Morphinans have a storied history in medicinal chemistry as pain management drugs but have received attention as modulators of cholinergic signaling for the treatment of Alzheimer’s Disease (AD). Galantamine is a reversible, competitive acetylcholinesterase (AChE) inhibitor and allosteric potentiating ligand of nicotinic acetylcholine receptors (nAChR-APL) that shares many common structural elements with morphinan-based opioids. The structurally diverse opioids codeine and eseroline, like galantamine, are also nAChR-APL that have greatly diminished affinity for AChE, representing potential lead compounds for selective nAChR-APL development. In accordance with the emerging repurposing trend of evaluating known compounds for novel pharmacological activity, ongoing research on augmentation of cholinergic signaling that has been aided by the use of opioids will be reviewed.

show abstract

Section: Opioid Receptor Ligandsmentioning

confidence: 99%

Cholinergic Modulation by Opioid Receptor Ligands: Potential Application to Alzheimer's Disease

Motel¹,

Coop²,

Cunningham³

2013

Mini Reviews in Medicinal Chemistry

View full text Add to dashboard Cite

show abstract

Endogenous opioid peptides in regulation of innate immunity cell functions

Гейн

Baeva

2011

Biochemistry Moscow

View full text Add to dashboard Cite

Endogenous opioid peptides comprise a group of bioregulatory factors involved in regulation of functional activity of various physiological systems of an organism. One of most important functions of endogenous opioids is their involvement in the interaction between cells of the nervous and immune systems. Summary data on the effects of opioid peptides on regulation of functions of innate immunity cells are presented.

show abstract

Opioid Receptor Signaling and Regulation

Cited by 2 publications

References 326 publications

Cholinergic Modulation by Opioid Receptor Ligands: Potential Application to Alzheimer's Disease

Cholinergic Modulation by Opioid Receptor Ligands: Potential Application to Alzheimer's Disease

Endogenous opioid peptides in regulation of innate immunity cell functions

Contact Info

Product

Resources

About