Opioid receptor-dependent long-term potentiation at the lateral perforant path-CA3 synapse in rat hippocampus

Breindl, Anette; Derrick, Brian E.; Rodrı́guez, S.; Martinez, Joe L.

doi:10.1016/0361-9230(94)90045-0

Cited by 53 publications

(57 citation statements)

References 22 publications

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“…Lowfrequency responses were evoked at 0.05 Hz with the average current intensity that elicited a response magnitude 50% of maximum slope as determined by these I/O curves. This intensity was used for all subsequent stimulation, except during LTP induction, at which point the current was turned up to that point which elicited 75% of maximal responding, which is necessary to induce LTP in perforant path projections to the DG (McNaughton et al, 1978) and is effective in inducing perforant path-CA3 LTP (Breindl et al, 1994). Ten responses were evoked at 20-sec intervals at a fixed time of day for each rat (usually during the middle of the light cycle).…”

Section: Methodsmentioning

confidence: 99%

“…As in the DG, hippocampal area CA3 responses to perforant path stimulation phase reverse upon penetration of the CA3 pyramidal cell layer (evidenced by stereotaxic coordinates and audio monitoring of cell firing), thus permitting verification of local CA3 responses (Breindl et al, 1994;Yeckel and Berger, 1990). The early component of the MPP-CA3 EPSP occurs prior to DG spike initiation, facilitating the isolated measurement of monosynaptic MPP-CA3 responses without mossy fiber-CA3 response contamination .…”

Section: Electrophysiologymentioning

confidence: 99%

“…The early component of the MPP-CA3 EPSP occurs prior to DG spike initiation, facilitating the isolated measurement of monosynaptic MPP-CA3 responses without mossy fiber-CA3 response contamination . Also, since dentate population spikes cannot follow stimulation trains of =20 Hz (Breindl et al, 1994), it is unlikely that population EPSP slopes of the MPP-CA3 responses were contaminated by disynaptic mossy fiber-CA3 activation. In addition, disynaptic activation of CA3 from mossy fibers subsequent to perforant path stimulation reliably occurs only within a narrow range of frequencies (5-15 Hz) and stimulation frequencies < 5 or > 20 Hz result primarily in monosynaptic excitation of CA3.…”

Section: Electrophysiologymentioning

confidence: 99%

“…Anatomical (Amaral et al, 1990), electrophysiological (Yeckel and Berger, 1990;Berzhanskaya et al, 1998), and functional metabolic (Jorgensen and Wright, 1988) studies report a strong, monosynaptic MPP-CA3 connection, which is well defined in the cat (Gloor et al, 1963), rabbit (Yeckel and Berger, 1998), and rat (Wu and Leung, 1998). Stimulation of this pathway is strong enough to activate synchronous firing of CA3 neurons and MPP-CA3 LTP can be induced in an NMDA receptor-dependent and opioid receptor-independent (Breindl et al, 1994) fashion. In addition, MPP-CA3 LTP has associative properties, which may have important implications for cognitive processes .…”

Section: Introductionmentioning

confidence: 99%

“…CA3 pyramidal cells are the first hippocampal neurons to respond to perforant path activation, often preceding the firing of DG granule cells (Yeckel and Berger, 1990;Breindl et al, 1994). Anatomical (Amaral et al, 1990), electrophysiological (Yeckel and Berger, 1990;Berzhanskaya et al, 1998), and functional metabolic (Jorgensen and Wright, 1988) studies report a strong, monosynaptic MPP-CA3 connection, which is well defined in the cat (Gloor et al, 1963), rabbit (Yeckel and Berger, 1998), and rat (Wu and Leung, 1998).…”

Section: Introductionmentioning

confidence: 99%

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Aging impairs the late phase of long‐term potentiation at the medial perforant path‐CA3 synapse in awake rats

Dieguez

Barea-Rodrı́guez

2004

Synapse

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The effects of aging on long-term potentiation (LTP) in the dentate gyrus (DG) and CA1 are well documented, but LTP at the medial perforant path (MPP)-CA3 synapse of aged animals has remained unexplored. Because the MPP-DG and Schaffer-collateral-CA1 synapses account for only about 20% of total hippocampal synapses, global understanding of how aging affects hippocampal plasticity has remained limited. Much is known about LTP induction in the hippocampal formation, whereas the mechanisms that regulate LTP maintenance are less understood, especially during aging. We investigated the effects of aging on MPP-CA3 LTP induction and maintenance in awake rats. As is the case in the DG and CA1, high-frequency stimulation-induced LTP at the MPP-CA3 synapse is normal in aged rats. These data indicate that N-methyl-D-aspartate (NMDA) receptor-mediated processes are intact at the MPP-CA3 synapse in aged rats. In contrast, aging impaired the magnitude and duration of MPP-CA3 LTP over a period of days. Also, these data are consistent with reports that area CA3 is especially susceptible to age-related changes. Our data suggest that aging impairs mechanisms that regulate the late phase of MPP-CA3 LTP and contribute to a more global understanding of how aging affects hippocampal plasticity.

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Section: Methodsmentioning

confidence: 99%

Section: Electrophysiologymentioning

confidence: 99%

Section: Electrophysiologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Aging impairs the late phase of long‐term potentiation at the medial perforant path‐CA3 synapse in awake rats

Dieguez

Barea-Rodrı́guez

2004

Synapse

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Revisiting the role of the hippocampal mossy fiber synapse

2001

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The mossy fiber pathway has long been considered to provide the major source of excitatory input to pyramidal cells of hippocampal area CA3. In this review we describe anatomical and physiological properties of this pathway that challenge this view. We argue that the mossy fiber pathway does not provide the main input to CA3 pyramidal cells, and that the short-term plasticity and amplitude variance of mossy fiber synapses may be more important features than their long-term plasticity or absolute input strength.

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Late postnatal maturation of excitatory synaptic transmission permits adult-like expression of hippocampal-dependent behaviors

Dumas

2005

Hippocampus

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Sensorimotor systems in altricial animals mature incrementally during early postnatal development, with complex cognitive abilities developing late. Of prominence are cognitive processes that depend on an intact hippocampus, such as contextual-configural learning, allocentric and idiocentric navigation, and certain forms of trace conditioning. The mechanisms that regulate the delayed maturation of the hippocampus are not well understood. However, there is support for the idea that these behaviors come "on line" with the final maturation of excitatory synaptic transmission. First, by providing a timeline for the first behavioral expression of various forms of learning and memory, this study illustrates the late maturation of hippocampal-dependent cognitive abilities. Then, functional development of the hippocampus is reviewed to establish the temporal relationship between maturation of excitatory synaptic transmission and the behavioral evidence of adult-like hippocampal processing. These data suggest that, in rats, mechanisms necessary for the expression of adult-like synaptic plasticity become available at around 2 postnatal weeks of age. However, presynaptic plasticity mechanisms, likely necessary for refinement of the hippocampal network, predominate and impede information processing until the third postnatal week.

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Opioid receptor-dependent long-term potentiation at the lateral perforant path-CA3 synapse in rat hippocampus

Cited by 53 publications

References 22 publications

Aging impairs the late phase of long‐term potentiation at the medial perforant path‐CA3 synapse in awake rats

Aging impairs the late phase of long‐term potentiation at the medial perforant path‐CA3 synapse in awake rats

Revisiting the role of the hippocampal mossy fiber synapse

Late postnatal maturation of excitatory synaptic transmission permits adult-like expression of hippocampal-dependent behaviors

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