Opioid receptor antagonists reduce motivated wheel-running behavior in mice
Nobue Kitanaka,
Kanayo Arai,
Kaoko Takehara
et al.
Abstract:We hypothesized that opioid receptor antagonists would inhibit motivated behavior produced by a natural reward. To evaluate motivated responses to a natural reward, mice were given access to running wheels for 71.5 h in a multi-configuration testing apparatus. In addition to a running wheel activity, locomotor activity (outside of the wheel), food and water intake, and access to a food container were measured in the apparatus. Mice were also tested separately for novel-object exploration to investigate whether… Show more
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