Opioid peptide inhibition of endogenous norepinephrine release from the A2 noradrenergic cell group in vitro

Carr, James A.; Gregg, Kathleen

doi:10.1016/0143-4179(95)90025-x

Cited by 11 publications

(5 citation statements)

References 30 publications

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“…• Suppression of attention to novelty via the inhibition of NE release [159, 160, 163-166] that would enhance a sense of predictability of the surroundings and of the capacity to handle it.…”

Section: The Roles Of or In Dispositions As A First Sketch Of Directionality Of Behaviour: The “?I!”-systemmentioning

confidence: 99%

“…Instead it is the failure of other systems that gives a way to hormonal systems to control the integration of actions, and DOR simply speeds up whatever was chosen. All 3 axes are suppressed by endorphins and enkephalins that bind to (and activate) MORs and DORs (marked here as “I!”) [93, 159, 160].…”

Section: Towards Taxonomies Of Contingencies In Neurochemical Construction Of Behaviourmentioning

confidence: 99%

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Contingent Tunes of Neurochemical Ensembles in the Norm and Pathology: Can We See the Patterns?

Trofimova¹

2021

Neuropsychobiology

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Background/Aims: Progress in the development of DSM/ICD taxonomies has revealed limitations of both label-based and dimensionality approaches. These approaches fail to address the contingent, nonlinear, context-dependent, and transient nature of those biomarkers linked to specific symptoms of psychopathology or to specific biobehavioural traits of healthy people (temperament). The present review aims to highlight the benefits of a functional constructivism approach in the analysis of neurochemical biomarkers underlying temperament and psychopathology. Method: A review was performed. Results: Eight systems are identified, and 7 neurochemical ensembles are described in detail. None of these systems is represented by a single neurotransmitter; all of them work in ensembles with each other. The functionality and relationships of these systems are presented here in association with their roles in action construction, with brief examples of psychopathology. The review introduces formal symbols for these systems to facilitate their more compact analysis in the future. Conclusion: This analysis demonstrates the possibility of constructivism-based unifying taxonomies of temperament (in the framework of the neurochemical model functional ensemble of temperament) and classifications of psychiatric disorders. Such taxonomies would present the biobehavioural individual differences as consistent behavioural patterns generated within a formally structured space of parameters related to the generation of behaviour.

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Section: The Roles Of or In Dispositions As A First Sketch Of Directionality Of Behaviour: The “?I!”-systemmentioning

confidence: 99%

Section: Towards Taxonomies Of Contingencies In Neurochemical Construction Of Behaviourmentioning

confidence: 99%

Contingent Tunes of Neurochemical Ensembles in the Norm and Pathology: Can We See the Patterns?

Trofimova¹

2021

Neuropsychobiology

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“…There is good consensus in neurochemistry on the key role of endorphins binding to mu-opioid receptors (MORs) in positive emotional valence, physical and emotional pain relief (Leknes, 2008;Bodnar, 2018), relaxation, feeling of security, and affiliation (Barr et al, 2008;Curley, 2011). The action of MOR, activated by endorphins, suppresses the activation of the Hypothalamicpituitary-adrenal (HPA) axis (i.e., suppresses mobilisation for an action) and induces the release of dopamine (DA) (Werling et al, 1988;Carr and Gregg, 1995;Degli Uberti et al, 1995;Yamauchi et al, 1997;Bodnar, 2018). There are several sites in the body and the brain that manufacture endorphins, and we can classify these sites into three groups (Figure 2).…”

Section: The Roles Of Opioid Receptor Systems In Emotional Valence and Alertnessmentioning

confidence: 99%

“…The other locations of MOR in the brain, which the endorphins bind to, were linked to behavioural homeostatic maintenance (Golgi cells in the cerebellum and in reticular formation) as well as motivational and programming processes [nucleus accumbens (NAc), ventral tegmental area (VTA), prefrontal cortex (PFC), amygdala (AM), HT, PAG] (Hamel and Beaudet, 1984;Nieuwenhuys, 1985;Peckys and Landwehrmeyer, 1999;Le Merrer et al, 2009). MOR, and also delta-opioid receptors (DORs), are G protein-coupled receptors (GPCRs) regulating the release of MAs, including the facilitation of dopamine release (Werling et al, 1988;Carr and Gregg, 1995;Degli Uberti et al, 1995;Yamauchi et al, 1997;Bodnar, 2018). Considering the "approval" effect of endorphins and their links to positive emotional valence, there is no surprise that these brain structures were noted for their involvement in motivation, planning, and anticipation.…”

Section: Endorphins Are Produced By the Bone Marrow Inmentioning

confidence: 99%

Emotionality vs. Other Biobehavioural Traits: A Look at Neurochemical Biomarkers for Their Differentiation

Trofimova

Gaykalova

2021

Front. Psychol.

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This review highlights the differential contributions of multiple neurochemical systems to temperament traits related and those that are unrelated to emotionality, even though these systems have a significant overlap. The difference in neurochemical biomarkers of these traits is analysed from the perspective of the neurochemical model, Functional Ensemble of Temperament (FET) that uses multi-marker and constructivism principles. Special attention is given to a differential contribution of hypothalamic–pituitary hormones and opioid neuropeptides implicated in both emotional and non-emotional regulation. The review highlights the role of the mu-opioid receptor system in dispositional emotional valence and the role of the kappa-opioid system in dispositional perceptual and behavioural alertness. These opioid receptor (OR) systems, microbiota and cytokines are produced in three neuroanatomically distinct complexes in the brain and the body, which all together integrate dispositional emotionality. In contrast, hormones could be seen as neurochemical biomarkers of non-emotional aspects of behavioural regulation related to the construction of behaviour in fast-changing and current situations. As examples of the role of hormones, the review summarised their contribution to temperament traits of Sensation Seeking (SS) and Empathy (EMP), which FET considers as non-emotionality traits related to behavioural orientation. SS is presented here as based on (higher) testosterone (fluctuating), adrenaline and (low) cortisol systems, and EMP, as based on (higher) oxytocin, reciprocally coupled with vasopressin and (lower) testosterone. Due to the involvement of gonadal hormones, there are sex and age differences in these traits that could be explained by evolutionary theory. There are, therefore, specific neurochemical biomarkers differentiating (OR-based) dispositional emotionality and (hormones-based) body’s regulation in fast-changing events. Here we propose to consider dispositional emotionality associated with OR systems as emotionality in a true sense, whereas to consider hormonal ensembles regulating SS and EMP as systems of behavioural orientation and not emotionality.

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“…Opioid peptides of all three classes (mu-, kappa-and delta-) are known to interact with dopaminergic systems within median eminence. A number of neural systems and estradiol (E) (Ben-Jonathan and Hnasko, 2001) are thought to be involved in opioid-mediated hormone release, including noradrenergic (Carr and Gregg, 1995), cholinergic (Kaur, 2001), GABAergic (Kaur, 2001), serotonergic (Foresta et al, 1986), and dopaminergic systems Schlussman et al, 2002).…”

Section: Prolactin Regulationmentioning

confidence: 99%

Effects of nalbuphine on anterior pituitary and adrenal hormones and subjective responses in male cocaine abusers

Goletiani

Mendelson

Sholar

et al. 2007

Pharmacology Biochemistry and Behavior

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Nalbuphine (Nubain®) is a mixed action mu-kappa agonist used clinically for the management of pain. Nalbuphine and other mu-kappa agonists decreased cocaine self-administration in preclinical models. Cocaine stimulates the hypothalamic-pituitary-adrenal (HPA) axis, but the effects of nalbuphine on the HPA axis are unknown. Analgesic doses (5 and 10 mg/70 kg) of IV nalbuphine were administered to healthy male cocaine abusers, and plasma levels of PRL, ACTH and cortisol were measured before and at 10, 17, 19, 23, 27, 31, 35, 40, 45, 60, 75, 105, 135 min after nalbuphine administration. Subjective effects were measured on a Visual Analog Scale (VAS). Prolactin (PRL) increased significantly within 17 min (P=.04) and reached peak levels of 22.1 ± 7.1 ng/ml and 54.1 ± 11.3 at 60 min after low and high dose nalbuphine administration, respectively. VAS reports of "Sick," "Bad" and "Dizzy" were significantly higher after 10 mg/70 kg than after 5 mg/70 kg nalbuphine (P=.05−.0001), and were significantly correlated with increases in PRL (P=.05−.0003). However, sedation and emesis were observed only after a 10 mg/70 kg dose of nalbuphine. Interestingly, ACTH and cortisol levels did not change significantly after administration of either dose of nalbuphine. Taken together, these data suggest that nalbuphine had both mu-and kappa-like effects on PRL (PRL increase) but did not increase ACTH and cortisol.

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Opioid peptide inhibition of endogenous norepinephrine release from the A2 noradrenergic cell group in vitro

Cited by 11 publications

References 30 publications

Contingent Tunes of Neurochemical Ensembles in the Norm and Pathology: Can We See the Patterns?

Contingent Tunes of Neurochemical Ensembles in the Norm and Pathology: Can We See the Patterns?

Emotionality vs. Other Biobehavioural Traits: A Look at Neurochemical Biomarkers for Their Differentiation

Effects of nalbuphine on anterior pituitary and adrenal hormones and subjective responses in male cocaine abusers

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