Learning Objectives: After participating in this CME activity, the spine surgeon should be better able to: 1. Summarize current literature on the impact of marijuana on postoperative opioid use. 2. Explain the relationship between marijuana use and surgical outcomes. 3. Describe the need for future research regarding marijuana in spine surgery.persistent legal limitations and social stigma of marijuana, medical research focusing on MC's potential benefit to the health care system is scarce. In addition, the heterogeneity of existing policies and various modes of drug consumption impede further understanding of the possible utility of marijuana consumption on patient outcomes. 2,3 Currently, cannabis is considered a Schedule 1 controlled substance by the US Drug Enforcement Agency's Comprehensive Drug Abuse Prevention and Control Act (Controlled Substances Act), indicating a high potential for abuse. However, compared to heroin, another Schedule 1 drug, the addictive potential of marijuana is far lower. The literature reports that only 9% of those who try marijuana develop dependence, compared with 24% of those who try heroin. 5 Moreover, pharmaceuticals derived from marijuana, THC, and cannabinoids (such as dronabinol, nabilone, and nabiximols) have been the focus of numerous studies concerning the treatment of nausea, pain, anorexia, weight loss, seizures, spasticity, and glaucoma. 6 Other potential applications of such drugs include the treatment of spasticity in multiple sclerosis, some psychiatric conditions, and movement disturbances. 7 The growing interest in MC is also driven by the potential use as an alternative to opioids, which is of interest given the current opioid crisis. Opiate overdoses have resulted in almost 400,000 deaths in the United States from 1999 to 2017, with synthetic opioids further exacerbating the incidence in recent years. 8 Unfortunately, given the significant reliance on opioids for postoperative pain control, surgeons Lippincott Continuing Medical Education Institute, Inc., is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Lippincott Continuing Medical Education Institute, Inc., designates this enduring material for a maximum of 1.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. To earn CME credit, you must read the CME article and complete the quiz and evaluation assessment survey on the enclosed form, answering at least 70% of the quiz questions correctly. Please go to http://cme.lww.com. This activity expires at 5 pm EST on June 30, 2025.