Opioid Overdose Detection in a Murine Model Using a Custom-Designed Photoplethysmography Device

Hoilett, Orlando S.; Ummel, Jason D.; Schepers, Luke E; Soepriatna, Arvin H.; Ma, Jessica L.; Fujita, Akio; Pickering, Alyson S.; Walters, Benjamin D.; Goergen, Craig J.; Linnes, Jacqueline C.

doi:10.1016/j.irbm.2023.100792

Cited by 2 publications

(2 citation statements)

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“…Our previous studies have validated the ability of NeoWarm to warm hypothermic (35°C) tissue phantoms (bottle filled with water) to 37°C (normal human body temperature) and maintain this temperature for 2 h with no overheating ( 47 , 48 ). These studies have also validated our ability to miniaturize our vital signs monitoring technology into a package that can be integrated into the neonatal carrier ( 53 – 58 ).…”

Section: Introductionmentioning

confidence: 80%

Preclinical validation of NeoWarm, a low-cost infant warmer and carrier device, to ameliorate induced hypothermia in newborn piglets as models for human neonates

Bluhm,

Tomlin,

Hoilett

et al. 2024

Front. Pediatr.

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IntroductionApproximately 1.5 million neonatal deaths occur among premature and small (low birthweight or small-for gestational age) neonates annually, with a disproportionate amount of this mortality occurring in low- and middle-income countries (LMICs). Hypothermia, the inability of newborns to regulate their body temperature, is common among prematurely born and small babies, and often underlies high rates of mortality in this population. In high-resource settings, incubators and radiant warmers are the gold standard for hypothermia, but this equipment is often scarce in LMICs. Kangaroo Mother Care/Skin-to-skin care (KMC/STS) is an evidence-based intervention that has been targeted for scale-up among premature and small neonates. However, KMC/STS requires hours of daily contact between a neonate and an able adult caregiver, leaving little time for the caregiver to care for themselves. To address this, we created a novel self-warming biomedical device, NeoWarm, to augment KMC/STS. The present study aimed to validate the safety and efficacy of NeoWarm.MethodsSixteen, 0-to-5-day-old piglets were used as an animal model due to similarities in their thermoregulatory capabilities, circulatory systems, and approximate skin composition to human neonates. The piglets were placed in an engineered cooling box to drop their core temperature below 36.5°C, the World Health Organizations definition of hypothermia for human neonates. The piglets were then warmed in NeoWarm (n = 6) or placed in the ambient 17.8°C ± 0.6°C lab environment (n = 5) as a control to assess the efficacy of NeoWarm in regulating their core body temperature.ResultsAll 6 piglets placed in NeoWarm recovered from hypothermia, while none of the 5 piglets in the ambient environment recovered. The piglets warmed in NeoWarm reached a significantly higher core body temperature (39.2°C ± 0.4°C, n = 6) than the piglets that were warmed in the ambient environment (37.9°C ± 0.4°C, n = 5) (p < 0.001). No piglet in the NeoWarm group suffered signs of burns or skin abrasions.DiscussionOur results in this pilot study indicate that NeoWarm can safely and effectively warm hypothermic piglets to a normal core body temperature and, with additional validation, shows promise for potential use among human premature and small neonates.

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Section: Introductionmentioning

confidence: 80%

Preclinical validation of NeoWarm, a low-cost infant warmer and carrier device, to ameliorate induced hypothermia in newborn piglets as models for human neonates

Bluhm,

Tomlin,

Hoilett

et al. 2024

Front. Pediatr.

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“…As shown in table 2, 69% of survey participants stated the funding led to publications including abstracts, posters and manuscripts, with a total of 18 manuscripts published or submitted at the time of the survey. [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] In addition, 69% of the respondents stated the funding led to further grant applications, with 38% of those applications resulting in successful funding. Most notably, 92% of all participants felt the funding mechanism helped All the respondents provided positive statements regarding RI potential to highlight mutual learning, building partnerships and collaborations, and shared innovation between contexts.…”

Section: Ghri Programme Evaluationmentioning

confidence: 99%

A Global Health Reciprocal Innovation grant programme: 5-year review with lessons learnt

Ruhl,

Kiplagat,

O'Brien

et al. 2023

BMJ Glob Health

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Unilateral approaches to global health innovations can be transformed into cocreative, uniquely collaborative relationships between low-income and middle-income countries (LMICs) and high-income countries (HIC), constituted as ‘reciprocal innovation’ (RI). Since 2018, the Indiana Clinical and Translational Sciences Institute (CTSI) and Indiana University (IU) Center for Global Health Equity have led a grants programme sculpted from the core elements of RI, a concept informed by a 30-year partnership started between IU (Indiana) and Moi University (Kenya), which leverages knowledge sharing, transformational learning and translational innovations to address shared health challenges. In this paper, we describe the evolution and implementation of an RI grants programme, as well as the challenges faced. We aim to share the successes of our RI engagement and encourage further funding opportunities to promote innovations grounded in the RI core elements. From the complex series of challenges encountered, three major lessons have been learnt: dedicating extensive time and resources to bring different settings together; establishing local linkages across investigators; and addressing longstanding inequities in global health research. We describe our efforts to address these challenges through educational materials and an online library of resources for RI projects. Using perspectives from RI investigators funded by this programme, we offer future directions resulting from our 5-year experience in applying this RI-focused approach. As the understanding and implementation of RI grow, global health investigators can share resources, knowledge and innovations that have the potential to significantly change the face of collaborative international research and address long-standing health inequities across diverse settings.

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Opioid Overdose Detection in a Murine Model Using a Custom-Designed Photoplethysmography Device

Cited by 2 publications

References 67 publications

Preclinical validation of NeoWarm, a low-cost infant warmer and carrier device, to ameliorate induced hypothermia in newborn piglets as models for human neonates

Preclinical validation of NeoWarm, a low-cost infant warmer and carrier device, to ameliorate induced hypothermia in newborn piglets as models for human neonates

A Global Health Reciprocal Innovation grant programme: 5-year review with lessons learnt

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