Opioid modulation of song in male zebra finches (Taenopygia guttata)

Khurshid, Nazia; Jayaprakash, Navin; Hameed, L. Shahul; Mohanasundaram, Sivaraj; Iyengar, Soumya

doi:10.1016/j.bbr.2009.12.003

Cited by 29 publications

(51 citation statements)

References 92 publications

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“…The density of m opioid receptors was highest in the VTA in this study. A recent study also reports m opioid receptor immunopositivity in VTA and POM in adult male zebra finches (Khurshid et al, 2010); other receptor subtypes were not measured and this species is not seasonal, so direct comparisons with the present study are limited. Systemi- cally administered fentanyl, a m opioid receptor-specific agonist, decreased singing in European starlings, particularly those males that normally sang at a high rate (Schroeder and Riters, 2006); central injections to specific brain regions are required to determine if the effect is mediated by reward centers studied here, by the song system itself, regions of which also express m opioid receptors Deviche, 1995, 1999;Khurshid et al, 2009), or perhaps is due to a non-specific narcotic effect.…”

Section: Discussionmentioning

confidence: 78%

“…Collectively, these studies suggest that opioid administration leads to satiety and reduces motivated behavior whereas opioid receptor antagonist treatment increases motivated behavior, as if the animal continues to try to receive an expected reward (Riters, 2009). Conversely, a recent study on zebra finches (Taenopygia guttata) found that systemic administration of a low (2.5 mg/kg), but not high (10 mg/kg), dose of naloxone decreases directed song rate and also affects spectral and temporal components of songs (Khurshid et al, 2010). The authors suggest that the dose-response profile reflects differential effects on the three opioid receptor subtypes at low vs. high dose, and that the opposite finding to that in European Starlings may be due to a species difference or to the fact that zebra finches with low song rates were excluded from their study.…”

Section: Introductionmentioning

confidence: 90%

See 1 more Smart Citation

Opioid receptor densities analyzed across seasons in the POM and VTA of the dark-eyed junco, Junco hyemalis

Woods

Deviche

Corbitt

2010

Journal of Chemical Neuroanatomy

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Section: Discussionmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 90%

Opioid receptor densities analyzed across seasons in the POM and VTA of the dark-eyed junco, Junco hyemalis

Woods

Deviche

Corbitt

2010

Journal of Chemical Neuroanatomy

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“…Previous studies have provided evidence linking dopamine (Heimovics et al, 2009; Merullo et al, 2016) and opioids (Khurshid et al, 2010; Riters et al, 2014) with undirected communication. Given that the endocannabinoid system interacts with these and other neurochemical systems to modulate motivation and reward (Solinas et al, 2007; 2008), future work should examine how these neural systems interact in the reward processes associated with vocal communication.…”

Section: Discussionmentioning

confidence: 99%

Song-associated reward correlates with endocannabinoid-related gene expression in male European starlings ( Sturnus vulgaris )

et al. 2017

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Vocal communication is required for successful social interactions in numerous species. During the breeding season, songbirds produce songs that are reinforced by behavioral consequences (e.g., copulation). However, some songbirds also produce songs not obviously directed at other individuals. The consequences maintaining or reinforcing these songs are less obvious and the neural mechanisms associated with undirected communication are not well-understood. Previous studies indicate that undirected singing is intrinsically rewarding and mediated by opioid or dopaminergic systems; however, endocannabinoids are also involved in regulating reward and singing behavior. We used a conditioned place preference paradigm to examine song-associated reward in European starlings and quantitative real-time PCR to measure expression of endocannabinoid-related neural markers (CB1, FABP7, FABP5, FAAH, DAGLα), in brain regions involved in social behavior, reward and motivation (ventral tegmental area [VTA], periaqueductal gray [PAG], and medial preoptic nucleus [POM]), and a song control region (Area X). Our results indicate that starlings producing high rates of song developed a conditioned place preference, suggesting that undirected song is associated with a positive affective state. We found a significant positive relationship between song-associated reward and CB1 receptors in VTA and a significant negative relationship between song-associated reward and CB1 in PAG. There was a significant positive relationship between reward and the cannabinoid transporter FABP7 in POM and a significant negative relationship between reward and FABP7 in PAG. In Area X, FABP5 and DAGLα correlated positively with singing. These results suggest a role for endocannabinoid signaling in vocal production and reward associated with undirected communication.

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“…Whether the self-motivated spaced training/practice of vocalization is generally observed in other vocal learners such as parrots, cetaceans and humans is yet to be investigated. Multiple lines of recent studies in songbirds showed a potential link of enkephalin and mu-opioid receptors in the medial preoptic nucleus and ventral tegmental area, which are highly conserved in mammals and birds to regulate undirected singing (Khurshid et al, 2010;Riters et al, 2005). However, the neural mechanisms underlying self-motivated singing behavior have not been well characterized, especially in the developmental changes of singing frequency and timing.…”

Section: Discussionmentioning

confidence: 99%

Diurnal oscillation of vocal development associated with clustered singing by juvenile songbirds

Ohgushi

Mori

Wada

2015

Journal of Experimental Biology

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Spaced practice affects learning efficiency in humans and other animals. However, it is not well understood how spaced practice contributes to learning during development. Here, we show the behavioral significance of singing frequency in song development in a songbird, the zebra finch. Songbirds learn a complex song pattern by trial-and-error vocalizations as self-motivated practice, which is executed over a thousand times per day during the sensitive period of vocal learning. Notably, juveniles generate songs with a high frequency of singing in clusters with dense singing, whereas adults sing with low frequency in short clusters. This juvenile-specific clustered singing was characterized by clear separations of daily time for intense practice and rest. During the epochs of vocal practice in juveniles, the song structure approached that of song produced at the end of the day. In contrast, during the epochs of vocal rest, the structure of juvenile songs regressed toward that of songs produced at the beginning of the day, indicating a dynamic progression and regression of song development over the course of the day. When the singing frequency was manipulated to decrease it at the juvenile stage, the oscillation rate of song development was dramatically reduced. Although the juvenile-specific clustered singing occurred in non-tutored socially isolated birds or those with auditory deprivation, the diurnal oscillation of vocal development was only observed in non-tutored isolated juveniles. These results show the impact of 'self-motivated' vocal practice on diurnal song developmental plasticity, modulated by the amount of vocal output and auditory feedback.

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Opioid modulation of song in male zebra finches (Taenopygia guttata)

Cited by 29 publications

References 92 publications

Opioid receptor densities analyzed across seasons in the POM and VTA of the dark-eyed junco, Junco hyemalis

Opioid receptor densities analyzed across seasons in the POM and VTA of the dark-eyed junco, Junco hyemalis

Song-associated reward correlates with endocannabinoid-related gene expression in male European starlings ( Sturnus vulgaris )

Diurnal oscillation of vocal development associated with clustered singing by juvenile songbirds

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