Opioid modulation of prolactin secretion induced by stress during late pregnancy. Role of ovarian steroids

Valdéz, Susana R.; Pennacchio, Gisela E.; Gamboa, Dante F.; Nasso, Elina G. de Di; Bregonzio, Claudia; Soaje, Marta

doi:10.1016/j.pharep.2013.12.006

Cited by 11 publications

(5 citation statements)

References 61 publications

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“…On the other hand, the previous observations have shown the link between the hyperthyroidism and delaying the milk ejections and suckling process [86][87][88][89][90]. Administration of 1 or 0.25mg/kg/day Thyroxine (T4) to rats caused the following [91][92][93] In general, the disruption in milk ejections due to hyperthyroidism can be explained as the following [95]:…”

Section: Commentarymentioning

confidence: 99%

Maternal Hyperthyroidism - Milk Ejections: What is the Association?

Rg¹

2018

TTSR

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Section: Commentarymentioning

confidence: 99%

Maternal Hyperthyroidism - Milk Ejections: What is the Association?

Rg¹

2018

TTSR

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“…For example, E2 could rapidly attenuate the ability of MOR to hyperpolarize hypothalamic (b-endorphin) neurons [48]. In reverse, opioid system also influences the prolactin release through the oestrogen regulation [49] or abolishes oestrogen-induced antinociception and hyperalgesia [50]. The sensitivity and the expressions of MOR reduced by E2 might decrease the responsiveness of MOR against its ligands (e.g.…”

Section: Systemic Versus Neuronal Action Of Oestrogen Effect In Mmt Pmentioning

confidence: 99%

Reduced dosing and liability in methadone maintenance treatment by targeting oestrogen signal for morphine addiction

Chiang

Wang

Huang

et al. 2017

J Cellular Molecular Medi

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Methadone maintenance treatment (MMT) is the major tapering therapy for morphine addictive patients. There have gender differences reported in response to MMT. This study discovered that the estrogen‐response element single nucleotide polymorphism (ERE‐SNP; rs16974799, C/T) of cytochrome 2B6 gene (cyp2b6; methadone catabolic enzyme) responded differently to MMT dosing. Oestradiol was associated with high MMT dosing, high enantiomer (R‐ or S‐) of 2‐ethylidene‐1,5‐dimethyl‐3,3‐dipheny‐pyrrolidine (EDDP; methadone metabolite) to methadone ratio and increased drug‐seeking behaviour, implicating oestradiol‐CYP‐EDDP/methadone axis decreasing MMT efficacy. In mouse model, oestrogen mitigates methadone antinociceptive response, facilitates methadone catabolism and up‐regulates methadone‐associated metabolizing enzymes. Oestrogen also ablates chronic methadone administration‐induced rewarding response. Mechanism dissection revealed the CC genotype of CYP2B6‐ERE‐SNP exerts higher ERE sequence alignment score, higher estrogenic response as compared to TT genotype. At last, preclinical study via targeting estrogen signal that tamoxifen (TMX; selective estrogen receptor modulator, SERM) could facilitate the tolerance phase rewarding response of methadone. Strikingly, TMX also reduces tapering/abstinence phases methadone liability in mice. In conclusion, this study demonstrates altering methadone metabolism through targeting estrogen signals might be able to free morphine addictive patients from the addiction of opioid replacement therapy. Therefore, the add‐on therapy clinical trial introducing SERM in MMT regimen is suggested.

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“…The animals were anesthetized with a combination of xylazine hydrochloride (4 mg/kg) and ketamine hydrochloride (80 mg/kg), injected i.p. between 09: 00 and 12: 00 h. Rats were positioned in a stereotaxic frame, and a stainless-steel guide cannula was inserted into the right lateral ventricle (M/L 1.5 mm, A/P-0.4 mm relative to bregma, 4.5 mm relative to dura [35]). Cannulae were fixed to the skull using dental acrylic and sealed until the time of drug injection.…”

Section: Animalsmentioning

confidence: 99%

“…On the morning of day 19 of pregnancy, the animals were treated with Mp (5 mg/kg, s.c.) or its vehicle (oil) at 08: 00 h, anesthetized with a combination of xylazine hydrochloride (4 mg/kg) and ketamine hydrochloride (80 mg/kg) injected i.p. between 09: 00 and 12: 00 h, and with sterile procedures a sterile silastic cannula (inside diameter 0.5 mm, outside diameter 0.94 mm; Dow Corning, Midland, MI, USA) was inserted into the jugular vein [35]. The cannula was externalized on the back of the head and fixed to the skin with a suture.…”

Section: Animalsmentioning

confidence: 99%

Role of Oxytocin in Prolactin Secretion during Late Pregnancy

et al. 2017

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Background/Aims: During late pregnancy, the blockade of progesterone action by mifepristone (Mp) treatment induces a dopaminergic tone fall that enables naloxone (NAL) administration to release pituitary prolactin (PRL). We determined whether oxytocin (OT), which stimulates PRL secretion acting directly on anterior pituitary lactotrophs, mediates the stimulatory action of Mp and NAL on PRL secretion during late pregnancy. Methods: On day 19 of pregnancy, circulating and pituitary OT and PRL levels were measured by radioimmunoassay, 10, 20, and 30 min after NAL (given at 17:30 h) in rats pretreated with Mp (at 08:00 h). Pituitary OT receptor (OTR) expression in Mp-treated rats was evaluated by RT-PCR. Activation of OT neurons in Mp-NAL-treated rats was measured counting double immunoreactive neurons for Fos and OT (Fos-OT-ir) in supraoptic nuclei (SON), and medial (PaMM) and lateral magnocellular divisions of paraventricular nuclei. Results: Elevated serum OT and decreased pituitary OT were observed 10 min after NAL administration in both vehicle- and Mp-treated rats. This PRL increase was prevented by previous i.p. administration of an OTR antagonist, but intracerebroventricular OT administration was ineffective. Mp increased pituitary OTR expression at 18:00 h. Only Mp-NAL increased Fos-OT-ir neurons in the PaMM and SON. Conclusions: These findings suggest that PRL secretion induced by Mp-NAL treatment is preceded by OT release. These results, together with the activation of hypothalamic OT neurons and the higher expression of pituitary OTR, support the hypothesis that, during late pregnancy, OT may act at the pituitary level to facilitate PRL secretion if the inhibitory action of progesterone is blocked.

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Opioid modulation of prolactin secretion induced by stress during late pregnancy. Role of ovarian steroids

Cited by 11 publications

References 61 publications

Maternal Hyperthyroidism - Milk Ejections: What is the Association?

Maternal Hyperthyroidism - Milk Ejections: What is the Association?

Reduced dosing and liability in methadone maintenance treatment by targeting oestrogen signal for morphine addiction

Role of Oxytocin in Prolactin Secretion during Late Pregnancy

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