2022
DOI: 10.1186/s12871-022-01747-w
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Opioid-free anesthesia compared to opioid anesthesia for laparoscopic radical colectomy with pain threshold index monitoring: a randomized controlled study

Abstract: Background Few studies have investigated the depth of intraoperative analgesia with non-opioid anesthesia. This study evaluated whether opioid-free anesthesia can provide an effective analgesia-antinociception balance monitored by the / pain threshold index in laparoscopic radical colectomy. Methods We enrolled 102 patients undergoing laparoscopic radical colectomy with general anesthesia. Participants were randomly allocated into two groups to rec… Show more

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Cited by 10 publications
(8 citation statements)
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References 26 publications
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“…Four RCTs specifically recruited female patients undergoing breast cancer or gynecologic surgery, [15–18] and the other 10 studies included surgical procedures for both male and female patients. [19–28]…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Four RCTs specifically recruited female patients undergoing breast cancer or gynecologic surgery, [15–18] and the other 10 studies included surgical procedures for both male and female patients. [19–28]…”
Section: Resultsmentioning
confidence: 99%
“…Four RCTs specifically recruited female patients undergoing breast cancer or gynecologic surgery, [15][16][17][18] and the other 10 studies included surgical procedures for both male and female patients. [19][20][21][22][23][24][25][26][27][28] In the control group, 6 studies used fentanyl alone, and the remaining 8 mostly combinedremifentanil, sufentanil, or morphine. In the opioid-free group, 6 non-opioid analgesics, including dexmedetomidine, ketamine, magnesium, lidocaine, ketorolac, and clonidine, as well as local nerve blocks, were used in 1 trial with anesthesia using inhaled isoflurane under nerve block to maintain spontaneous breathing, while the other 13 studies used two or more drugs or combined local nerve blocks instead of opioids.…”
Section: Resultsmentioning
confidence: 99%
“…However, the mean induction time was 12 min shorter in the CWI than in the TEA group (24 min. [IQR [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] vs. 36 min. [IQR 28-52]; p = 0.001).…”
Section: Resultsmentioning
confidence: 99%
“…Nevertheless, the use of CWI versus TEA for lumbotomy should also be addressed in a RCT before a definitive conclusion can be drawn. The increases in opioid consumption in the CWI group should be further addressed with other components of multimodal analgesia techniques, such as the use of intraoperative Dexmedetomidine infusions, for example [28].…”
Section: Discussionmentioning
confidence: 99%
“…The incidence of postoperative nausea and vomiting was also not significantly different. [24] A hysteroscopy procedure was performed on 90 patients. Lidocaine was administered in half of them, and sufentanyl in the other half.…”
Section: Research On Postoperative Painmentioning
confidence: 99%