Opioid and nociceptin receptors regulate cytokine and cytokine receptor expression

Finley, Mathew J.; Happel, Christine; Kaminsky, David E.; Rogers, Thomas J.

doi:10.1016/j.cellimm.2007.09.008

Cited by 118 publications

(82 citation statements)

References 87 publications

(69 reference statements)

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“…Opioids regulate the expression of inflammatory cytokines and their receptors, and immune cells under the influence of cytokines can release endogenous opioids at sites of inflammation [33,55,56]. It has [21] been suggested that the κ-and μ-opioid receptors play opposing roles, with the κ-opioid receptor activation inducing an anti-inflammatory response while the μ-opioid receptor favors a pro-inflammatory response [57]. However, the picture is far more complex.…”

Section: Opioids and Inflammation Are Closely Interrelatedmentioning

confidence: 99%

Morphine and tumor growth and metastasis

Afsharimani

Cabot

Parat

2011

Cancer Metastasis Rev

152

116

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Morphine is an analgesic widely used to alleviate cancer pain. In addition, the perioperative management of pain in cancer surgery patients most often includes opioids. However, there are reports that these drugs may alter cancer recurrence or metastasis. Several mechanisms have been proposed, such as the modulation of the immune response or cellular pathways that control the survival and migratory behavior of cancer cells. The published literature, however, presents some discrepancies, with reports suggesting that opioids may either promote or prevent the spread of cancer. It is of great importance to determine whether opioids, in particular the most widely used, morphine, may increase the risk of metastasis when used in cancer surgery. This review examines the available data on the effects of morphine which influence cancer metastasis or recurrence, including immunomodulation, tumor cell aggressiveness, and angiogenesis, with special emphasis on recently published clinical and laboratory based studies. We further discuss the parameters that may explain the difference between reports on the effects of morphine on cancer.

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Section: Opioids and Inflammation Are Closely Interrelatedmentioning

confidence: 99%

Morphine and tumor growth and metastasis

Afsharimani

Cabot

Parat

2011

Cancer Metastasis Rev

152

116

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“…1a,b), indicating that the absence of opioid receptors does not markedly alter T lymphocytes proliferative capabilities under these conditions. Exposure to opiates has been shown previously to alter TH cytokine profiles (Finley et al 2008). Here, we investigated whether global opioid receptor deletion would impact on TH1/TH2 cytokines by analysing IL-2 and IFNγ TH1 and IL-4 TH2 cytokines in supernatants by ELISA under the same T lymphocyte stimulatory conditions than for proliferation.…”

Section: Proliferation and Cytokine Responsesmentioning

confidence: 95%

Influence of Endogenous Opioid Systems on T Lymphocytes as Assessed by the Knockout of Mu, Delta and Kappa Opioid Receptors

Karaji

Reiss

Matifas

et al. 2011

J Neuroimmune Pharmacol

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Here, we evaluated the influence of endogenous opioid activation on immune responses by examining consequences of all three opioid receptor gene (mu, delta and kappa) inactivation. In triple-opioid receptor knockout mice, splenocytes and thymocytes numbers, lymphocyte subsets as well as proliferation and cytokines induced by in vitro stimulation of T lymphocytes were measured. Compared with wild-type mice, similar lymphocyte distribution in thymus and spleen as well as comparable T lymphocyte proliferation were observed, while lower levels of IL-2 and IFNγ as well as higher levels of IL-4 and IL-10 were found in triple-opioid receptor knockout mice. Together, our results indicate a shift from TH1 to TH2 cytokines in triple-opioid receptor knockout animals, suggesting that global endogenous opioid tone drives T lymphocytes toward a TH1 profile under non-pathological conditions.

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“…Equally, the practice is also reported to cause a dysregulation in cytokine production [87,88]. For instance, levels of circulating Acrp30 are revealed to be markedly reduced in frequently injecting heroin addicts [23,24].…”

Section: Illicit Substance Use and Adiponectin Productionmentioning

confidence: 99%

Adiponectin Secretion in HIV-Infected Subjects with or without Antiretroviral Treatment and Illicit Substance Use: Clinical Review and Update

Kiboi¹,

Karanja²,

Nebere³

2016

Biol Med (Aligarh)

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Adiponectin (Acrp30) is a novel polypeptide classified among adipokines that are chiefly secreted by adipocytes within adipose tissue. Besides the adipose tissue, levels of the adipocytokine also circulate in human plasma. Functionally, Acrp30 possesses a primary role in regulation of body fat stores with its anti-inflammatory, glucose and lipid metabolism and weight loss effects. Thus, circulating Acrp30 levels govern obesity and metabolic abnormalities including; dyslipidaemia, cardiovascular disorders and renal disease. A lipodystrophic syndrome including metabolic derangements are common features presenting in HIV-infected patients on antiretroviral therapy (ART). Decreased Acrp30 levels have been documented in lipodystrophic patients as a consequence of adverse effects attributable to various antiretroviral agents. Interestingly, Acrp30 levels are revealed to be suppressed in HIV-infected patients relative to healthy persons even prior to HAART commencement, indicative of HIV infection itself playing a role in Acrp30 dysregulation. On the contrary, circulating Acrp30 levels inversely correlate with body fat composition in healthy non-obese individuals. Thus, lowered Acrp30 concentrations are associated with weight accumulation in obese subjects. More importantly, illicit drug and substance use has been revealed to accelerate HIV disease progression while also impairing Acrp30 production within the adipose tissue. Consequently, these observations collectively portray Acrp30 as a metabolic correlate of adipose tissue inflammation and low fat store during episodes of HIV infection, lypodystrophyic syndrome and illicit substance use. Therapeutic interventions should identify new approaches to restore Acrp30 production and supply during the aforementioned events.

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Opioid and nociceptin receptors regulate cytokine and cytokine receptor expression

Cited by 118 publications

References 87 publications

Morphine and tumor growth and metastasis

Morphine and tumor growth and metastasis

Influence of Endogenous Opioid Systems on T Lymphocytes as Assessed by the Knockout of Mu, Delta and Kappa Opioid Receptors

Adiponectin Secretion in HIV-Infected Subjects with or without Antiretroviral Treatment and Illicit Substance Use: Clinical Review and Update

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