Opioid Anaesthesia—fact or Fallacy?

Thirty-six patients (29 males and 7 females) undergoing open-heart surgery received one of three different dose regimens of lorazepam. All received a weight-related oral dose (2 mg, 3 mg or 4 mg) pre-operatively for night sedation. Twenty-four patients had an additional weight-related dose (2 mg, 3 mg or 4 mg intravenously) either as part of the induction (12 patients) or just prior to connection of the heart-lung machine (12 patients). Plasma concentrations of lorazepam were measured 20 minutes after induction, immediately before bypass, 30 and 60 on bypass and 30 minutes after bypass. Only when additional intravenous lorazepam was given prior to connection to the heart-lung machine were plasma lorazepam concentrations obtained compatible with complete amnesia.

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Opioid Anaesthesia—fact or Fallacy?

Cited by 4 publications

References 11 publications

Opioids in Patients with Cardiac Disease

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Lorazepam in Open-Heart Surgery — Plasma concentrations before, during and after bypass following different dose regimens

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