Opinions about new reproductive genetic technologies: Hopes and fears for our genetic future

Kalfoglou, Andrea L.; Doksum, Teresa; Bernhardt, Barbara A.; Geller, Gail; LeRoy, Lisa; Mathews, Debra J. H.; Evans, John H.; Doukas, David J.; Reame, Nancy E.; Scott, Joan A.; Hudson, Kathy

doi:10.1016/j.fertnstert.2005.01.090

Cited by 42 publications

(48 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In general, pregnancy termination proved to be less acceptable for adult-onset diseases than for congenital abnormalities or serious diseases with onset in childhood. 24,25 In our study, pregnancy termination was considered an important drawback of PD and was perceived as psychologically and physically demanding. For some couples, it was an insurmountable objection against PD.…”

Section: Discussionmentioning

confidence: 82%

“…In case of IVF with PGD, the burden associated with the complex way of conceiving and the low success rate were mentioned as disadvantages by some couples. A study on attitudes towards the new reproductive genetic technologies 25 reported that in general, PD was considered less acceptable than PGD because of the emotional trauma in case of an abortion. In this study, most couples had undergone PD partly because PGD only became available in 1998.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The complexity of reproductive decision-making in asymptomatic carriers of the Huntington mutation

et al. 2007

View full text Add to dashboard Cite

The aim of this study was to describe reproductive decisions in mutation carriers after predictive testing for Huntington's disease (HD) and to identify factors that play a role in decision-making. In -2004 individuals received a predictive test result; 89 of them were carriers and seven received an equivocal result. Quantitative data on reproductive behaviour have been collected during all follow-up contacts. The follow-up time in this study was 1-16 years (mean: 7.1 years). Qualitative data on reproductive decisionmaking have been collected by the means of semistructured interviews during the 5-year follow-up study. For 46 carriers and two persons with an equivocal result, family planning was one of the motives for predictive testing. In this group, slightly more than half of the carriers (58%) had chosen to have children with prenatal diagnosis or preimplantation genetic diagnosis and about one in three (35%) decided to have no children anymore after the test. A minority (7%) was undecided or had no children for other reasons. Factors playing a role in the decision-making process were the carrier's sex, ethical issues about PD and PGD, the strength of the desire to have children, illness representations including personal experiences with HD in the family and the technological imperative. Some of these elements were in conflict and induced ambivalence towards reproductive choices. The results illustrate the complexity of the decision-making process and the necessity of in-depth counselling. Counselling should pay special attention to conflicting values and beliefs and to all kinds of pressure.

show abstract

Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

The complexity of reproductive decision-making in asymptomatic carriers of the Huntington mutation

et al. 2007

View full text Add to dashboard Cite

show abstract

“…A survey conducted by the HFEA found that, of those that agreed with PGD, the reasons for doing so were because it prevented further suffering within families where the condition is present and was a preferable technology to prenatal diagnosis [3]. Studies of the US general public, including PGD users, stress the importance of individual decision making regarding reproductive genetic technologies [19,31,32].…”

Section: Discussionmentioning

confidence: 99%

Conflict between values and technology: perceptions of preimplantation genetic diagnosis among women at increased risk for hereditary breast and ovarian cancer

et al. 2009

View full text Add to dashboard Cite

Members of families affected by hereditary cancer are often concerned about passing on risk to offspring. Preimplantation genetic diagnosis is a procedure performed to identify embryos that inherit mutations placing them at risk for hereditary conditions. Little is known about attitudes toward the use of this technology among individuals at risk for hereditary breast and ovarian cancer. We sought to determine high risk women's attitudes. This study is a qualitative examination of comments from women who participated in an online survey regarding knowledge and attitudes of preimplantation genetic diagnosis among individuals affected by hereditary breast and ovarian cancer. More than half the respondents held less favorable attitudes about the use of preimplantation genetic diagnosis for hereditary breast and ovarian cancer for both themselves and others. However, among the women who felt favorable about its usage, the majority said it became a new option for them to pursue parenthood whereas previously they had opted to not have a biological child. The high percentage of respondents who have never heard of preimplantation genetic diagnosis and who were in favor of this technology for hereditary breast and ovarian cancer indicates the need for educational campaigns to increase awareness and provide information about the procedure, access and affordability. Further research is needed to determine how this population would like this information presented to them and how best to instruct health care professionals to present this topic to women who do not know to ask about it.

show abstract

“…The focus group and interview responses provide a detailed and textured portrait of peoples' attitudes (31)(32)(33).…”

Section: Policy Issues and Public Attitudesmentioning

confidence: 99%

“…Some focus group participants expressed their belief that from the time of conception, a human life has been created that has the same moral status as a liveborn child, whereas others felt that a human embryo is merely a clump of cells with no special moral standing (31). To assess the views on the moral status of human embryos in the general population, respondents to an April 2004 survey (33) were asked to rank on a five-point scale the moral worth of an embryo, a fetus at various stages, and a born baby.…”

Section: Considering "Acceptable" Uses Of Pgdmentioning

confidence: 99%

Preimplantation genetic diagnosis: public policy and public attitudes

Hudson

2006

Fertility and Sterility

View full text Add to dashboard Cite

Opinions about new reproductive genetic technologies: Hopes and fears for our genetic future

Cited by 42 publications

References 15 publications

The complexity of reproductive decision-making in asymptomatic carriers of the Huntington mutation

The complexity of reproductive decision-making in asymptomatic carriers of the Huntington mutation

Conflict between values and technology: perceptions of preimplantation genetic diagnosis among women at increased risk for hereditary breast and ovarian cancer

Preimplantation genetic diagnosis: public policy and public attitudes

Contact Info

Product

Resources

About