Opinion of the Scientific Panel on Dietetic products, nutrition and allergies [NDA] related to the Tolerable Upper Intake Level of Vanadium

,

doi:10.2903/j.efsa.2004.33

Cited by 11 publications

(6 citation statements)

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“…Boron is not an essential nutrient for humans and any specific biochemical functions have not been identified. There is however, some evidence that, in humans, B may influence the metabolism and utilisation of other nutrients, especially calcium, and may have a beneficial effect on bone calcification and maintenance (EFSA, 2004a ; Zioła‐Frankowska et al, 2014 ). Symptoms related to B intoxication includes gastrointestinal disturbances, granular degeneration of tubular cells, exfoliate dermatitis, epilepsy, cardio‐circulatory collapse.…”

Section: Discussionmentioning

confidence: 99%

“…A tolerable upper intake level (UL) was based on the decreased fetal body weight in rats resulting from maternal boron intake during pregnancy. The NOAEL for this effect (9.6 mg/kg bw per day) was extrapolated to humans by application of uncertainty factor of 60 (including intra‐ and interspecies variability) to give an UL of 0.16 mg/kg bw per day (EFSA, 2004a ).…”

Section: Discussionmentioning

confidence: 99%

“…The most common non‐occupational sources of vanadium exposure are contaminated food and drinking water (Rodríguez‐Mercado et al, 2011 ; Crebelli and Leopardi, 2012 ). High concentrations of V may cause irreversible damage to the kidneys (EFSA, 2004b ). However, vanadium in mammalian species can accumulate in the liver, kidneys, bones, lungs and spleen (Rodríguez‐Mercado et al, 2011 ; Crebelli and Leopardi, 2012 ).…”

Section: Discussionmentioning

confidence: 99%

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Risk assessment of rare earth elements, antimony, barium, boron, lithium, tellurium, thallium and vanadium in teas

Kowalczyk

Givelet

Amlund

et al. 2022

EFS2

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In recent years, a great intensification in the use of various elements especially in modern technology can be observed. However, the anthropogenic activities, including industrialisation, urbanisation or intensive agriculture, have led to the release of many of the elements into the environment. The consequence of the accumulation of the elements both in soil and water systems is their presence in the food chain. Inhalation and consumption of the contaminated food and beverages have been indicated as the main pathways of the exposure to many elements. Due to the fact, that tea is considered the second most popular beverage worldwide and its consumption is constantly increasing, it is crucial to evaluate the safety of the product, especially for toxic elements contamination. Thus, the aim of the project was to evaluate the contamination levels of rare earth elements (REEs) including lanthanides, scandium (Sc) and yttrium (Y) and also antimony (Sb), barium (Ba), boron (B), lithium (Li), tellurium (Te), thallium (Tl) and vanadium (V) in teas. Subsequently, the risk assessment was carried out. Additionally, the Fellowship provided hands‐on training on the evaluation of applications of new biocides and participation in the science‐based advises given to the Danish Food and Veterinary Administration, Danish Environment Protection Agency and Danish Medical Agency.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Risk assessment of rare earth elements, antimony, barium, boron, lithium, tellurium, thallium and vanadium in teas

Kowalczyk

Givelet

Amlund

et al. 2022

EFS2

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“…The recommended daily intake for humans of Al, Fe and V ions is ca. 50 mg [51], 6-20 mg [52] and 1.8 mg [53], respectively. This amount would be enough to crosslink large volumes of the presented inks, i.e.…”

Section: Discussionmentioning

confidence: 99%

Printability study of metal ion crosslinked PEG-catechol based inks

et al. 2020

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In this paper we explore the printability of reversible networks formed by catechol functionalized PEG solutions and metal cations (Al3+, Fe3+ or V3+). The printability and shape fidelity were dependent on the ink composition (metal ion type, pH, PEG molecular weight) and printing parameters (extrusion pressure and printing speed). The relaxation time, recovery rate and viscosity of the inks were analyzed in rheology studies and correlated with thermodynamic and ligand exchange kinetic constants of the dynamic bonds and the printing performance (i.e. shape fidelity of the printed structures). The relevance of the relaxation time and ligand exchange kinetics for printability was demonstrated. Cells seeded on the materials crosslinked with Al3+, Fe3+ ions were viable and revealed well-spread morphologies during 7 day culture, indicating the potential of the formulations to be used as inks for cell encapsulation. The proposed dynamic ink design offers significant flexibility for 3D bioprinting, and enables straightforward adjustment of the printable formulation to meet application-specific needs.

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“…As for the health status, Sampath et al [30] have recently supported the hypothesis that an imbalance of vanadium (the concentration of which was significantly reduced in the serum following treatment) is a factor in the etiology of one of mental illnesses, i.e., bipolar disorder. Furthermore, dietary supplements frequently used by athletes and body builders to improve performance [31], in which vanadium may be present in the form of, e.g., vanadyl sulfate [11], are equally important. As reported, the prolonged consumption of such supplements, with daily doses up to 18 mg V/day/person, may pose a risk of adverse health effects [31].…”

Section: The Impact Of Certain Factors On the Concentration Of Vanadi...mentioning

confidence: 99%

CNS-Related Effects Caused by Vanadium at Realistic Exposure Levels in Humans: A Comprehensive Overview Supplemented with Selected Animal Studies

Ścibior

Llopis

Dobrakowski

et al. 2023

IJMS

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Neurodegenerative disorders, which are currently incurable diseases of the nervous system, are a constantly growing social concern. They are progressive and lead to gradual degeneration and/or death of nerve cells, resulting in cognitive deterioration or impaired motor functions. New therapies that would ensure better treatment results and contribute to a significant slowdown in the progression of neurodegenerative syndromes are constantly being sought. Vanadium (V), which is an element with a wide range of impacts on the mammalian organism, is at the forefront among the different metals studied for their potential therapeutic use. On the other hand, it is a well-known environmental and occupational pollutant and can exert adverse effects on human health. As a strong pro-oxidant, it can generate oxidative stress involved in neurodegeneration. Although the detrimental effects of vanadium on the CNS are relatively well recognized, the role of this metal in the pathophysiology of various neurological disorders, at realistic exposure levels in humans, is not yet well characterized. Hence, the main goal of this review is to summarize data on the neurological side effects/neurobehavioral alterations in humans, in relation to vanadium exposure, with the focus on the levels of this metal in biological fluids/brain tissues of subjects with some neurodegenerative syndromes. Data collected in the present review indicate that vanadium cannot be excluded as a factor playing a pivotal role in the etiopathogenesis of neurodegenerative illnesses, and point to the need for additional extensive epidemiological studies that will provide more evidence supporting the relationship between vanadium exposure and neurodegeneration in humans. Simultaneously, the reviewed data, clearly showing the environmental impact of vanadium on health, suggest that more attention should be paid to chronic diseases related to vanadium and to the assessment of the dose–response relationship.

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Opinion of the Scientific Panel on Dietetic products, nutrition and allergies [NDA] related to the Tolerable Upper Intake Level of Vanadium

Cited by 11 publications

References 76 publications

Risk assessment of rare earth elements, antimony, barium, boron, lithium, tellurium, thallium and vanadium in teas

Risk assessment of rare earth elements, antimony, barium, boron, lithium, tellurium, thallium and vanadium in teas

Printability study of metal ion crosslinked PEG-catechol based inks

CNS-Related Effects Caused by Vanadium at Realistic Exposure Levels in Humans: A Comprehensive Overview Supplemented with Selected Animal Studies

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