Opiates inhibit neurogenesis in the adult rat hippocampus

Eisch, Amelia J.; Barrot, Michel; Schad, Christina A.; Self, David W.; Nestler, Eric J.

doi:10.1073/pnas.120552597

Cited by 534 publications

(412 citation statements)

References 58 publications

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“…Other non-antidepressant psychotropic drugs tested, including haloperidol and morphine, do not up-regulate adult neurogenesis. In fact, morphine treatment is reported to decrease neurogenesis in adult hippocampus (Eisch et al 2000). These results suggest that increased neurogenesis is pharmacologically specific for antidepressants.…”

Section: Antidepressant Treatment Increases Adult Neurogenesismentioning

confidence: 84%

Regulation of Adult Neurogenesis by Antidepressant Treatment

Duman

Nakagawa

Malberg

2001

Neuropsychopharmacology

418

249

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Demonstration of neurogenesis in adult brainOur understanding of how the brain functions and undergoes adaptation and plasticity has changed dramatically over the past several years. A great deal of work has demonstrated that altered levels of neurotransmitters, second messenger pathways, and gene expression profiles underlie cellular and behavioral plasticity. This includes models of learning and memory as well as models of depression, anxiety, and psychosis, and the long-term actions of psychotropic drugs. However, it is now becoming increasing evident that changes in cellular morphology and even more pronounced alterations in brain structure also contribute to neural plasticity or remodeling. At the cellular level these changes can occur in the form of up or down-regulation of synapse formation and spine density or extension and retraction of dendrites. Another very dramatic example is up or down-regulation of neurogenesis in adult brain. Studies in recent years demonstrate that new cell birth occurs in adult brain and that the rate of neurogenesis and the survival of new neurons is regulated by a number of environmental, endocrine, and pharmacological treatments.In this paper we discuss the evidence that structural remodeling may be involved in the pathophysiology and treatment of mood disorders. The potential role of neurogenesis is also discussed as well as the molecular mechanisms which underlie antidepressant regulation of new cell birth and survival. The studies to date suggest an exciting possibility for the role of neurogenesis

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Section: Antidepressant Treatment Increases Adult Neurogenesismentioning

confidence: 84%

Regulation of Adult Neurogenesis by Antidepressant Treatment

Duman

Nakagawa

Malberg

2001

Neuropsychopharmacology

418

249

View full text Add to dashboard Cite

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“…Long-term opiate use may induce maladaptive plasticity in brain structures involved in learning and memory, such as the hippocampus (Eisch et al, 2000). The hippocampus plays an important role in spatial and contextual learning (Holland and Bouton, 1999;Suzuki, 2006).…”

Section: Discussionmentioning

confidence: 99%

Chronic Morphine Selectively Impairs Cued Fear Extinction in Rats: Implications for Anxiety Disorders Associated with Opiate Use

et al. 2007

Neuropsychopharmacol

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Previous studies have shown that opioid transmission plays an important role in learning and memory. However, little is known about the course of opiate-associated learning and memory deficits after cessation of chronic opiate use in a behavioral animal model. In the present study, we examined the effects of chronic morphine on fear extinction, an important preclinical model for behavior therapy of human anxiety disorders. Rats were administrated subcutaneously morphine hydrochloride or saline twice per day for continuous 10 days. Rats received a cued or contextual fear conditioning session 7 days after the last morphine injection. During subsequent days, rats received four cued or contextual extinction sessions (one session per day). Percent freezing was assessed during all phases of training. Chronic morphine did not affect the acquisition of cued fear response or the initial encoding of extinction memory within each session, but produced an impairment in the between-session extinction. However, the same morphine treatment schedule did not affect the acquisition or extinction of contextual fear response. These results suggest that the effects of chronic morphine on memory for fear extinction are complex. Chronic morphine selectively impairs extinction of cued fear response. This deficit in fear extinction may be one of those critical components that contribute to the high prevalence of anxiety disorders in opiate addicts.

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“…It has been proposed that drug regulation of neurogenesis in the adult rat hippocampus may be one mechanism by which drug exposure influences hippocampal function (Eisch et al, 2000). Thus drug-induced expression of axon guidance cues, particularly the Ephs and Ephrins, may be part of this process, which may recapitulate expression patterns of cues induced in earlier stages during development.…”

Section: Drug-induced Expression Changes Of Axon Guidance Cues May Bementioning

confidence: 99%

Cocaine-induced expression changes of axon guidance molecules in the adult rat brain

Bahí

Dreyer

2005

Molecular and Cellular Neuroscience

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Administration of drugs of abuse induces strong molecular adaptations and plasticity within the mesolimbic dopamine (DA) system, a pathway essential for reward-seeking behavior. Little is known about the specific targets involved in this neuroadaptation process, but there are indications that cocaine and other drugs of abuse share the ability to alter the morphology of neuronal dendrites and spines, the primary site of excitatory synapses in the brain. Axon guidance molecules, the very molecular cues that regulate the formation of axon-target connections during development, may mediate these alterations. To test this hypothesis, we investigated mRNA expression changes of 39 axon guidance molecules, including 17 Semaphorins, 12 Ephs, 8 Ephrins and 2 neuropilins in the mesolimbic dopamine system of cocaine-treated animals under different paradigms by mean of DNA-Microarray and quantitative real-time PCR. In all cases, strong changes in gene expression are observed, yielding to up or down-regulation of these axon guidance molecules. Our data suggest that cocaine treatment induces activation of a complex program of synaptic rearrangements, which may partly recapitulate the plastic changes occurring during development, and may underlie the important neuroplastic adaptations that occur in the reward-and memory-related brain centers following drug action. We conclude that in some brain regions, exposure to psychomotor-stimulant drugs produce expression changes in axon guidance molecules, which may contribute to cognitive deficits associated with drug abuse.2

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Opiates inhibit neurogenesis in the adult rat hippocampus

Cited by 534 publications

References 58 publications

Regulation of Adult Neurogenesis by Antidepressant Treatment

Regulation of Adult Neurogenesis by Antidepressant Treatment

Chronic Morphine Selectively Impairs Cued Fear Extinction in Rats: Implications for Anxiety Disorders Associated with Opiate Use

Cocaine-induced expression changes of axon guidance molecules in the adult rat brain

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