Opiate effects of isolation stress in domestic fowl

Sufka, Kenneth J.; Hughes, Richard A.; McCormick, Tammy M.; Borland, James L.

doi:10.1016/0091-3057(94)90257-7

Cited by 30 publications

(25 citation statements)

References 31 publications

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“…This result aligns with studies in young rodents and other species showing that exogenously administered opioids reduce behavioral measures of distress in response to social isolation (Bos et al, 2012; Herman and Panksepp, 1978; Panksepp et al, 1978; Stein et al, 2007; Sufka et al, 1994), perhaps by reducing the perception of the social rejection itself. In chicks, this distress-reducing effect was blocked by the administration the opioid antagonist naloxone (Panksepp et al, 1980).…”

Section: Discussionsupporting

confidence: 87%

Effects of buprenorphine on responses to social stimuli in healthy adults

Bershad

Seiden

Wit

2016

Psychoneuroendocrinology

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In addition to its classical role in mediating responses to pain, the opioid system is strongly implicated in the regulation of social behavior. In young laboratory animals, low doses of opioid analgesic drugs reduce responses to isolation distress and increase play behavior. However, little is known about how opioid drugs affect responses to social stimuli in humans. Here we examined the effects of buprenorphine, a mu-opioid partial agonist and kappa-antagonist, on three dimensions of social processing; i) responses to simulated social rejection, ii) attention to emotional facial expressions, and iii) emotional responses to images with and without social content. Healthy adults (N = 36) attended two sessions during which they received either placebo or 0.2mg sublingual buprenorphine in randomized order, under double-blind conditions. Ninety minutes after drug administration, they completed three behavioral tasks: i) a virtual ball-toss game in which they were first included and then excluded by the other players; ii) an attention task in which they were shown pairs of faces (one emotional and one neutral), while the direction of their gazes was recorded using electrooculography, and iii) a picture-viewing task, in which they rated standardized images with and without social content. During the ball-toss game, buprenorphine decreased perceived social rejection. During the attention task, the drug reduced initial attention to fearful facial expressions, without influencing attention to angry, happy, and sad faces. Finally, during the picture-viewing task, buprenorphine increased ratings of positivity of images with social content, without affecting ratings of nonsocial images. These results suggest that even at low doses, opioid analgesic drugs reduce responses to some types of negative social stimuli, while enhancing positive responses to social stimuli. This provides further support for the role of the opioid system in mediating responses to social rejection and social reward.

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Section: Discussionsupporting

confidence: 87%

Effects of buprenorphine on responses to social stimuli in healthy adults

Bershad

Seiden

Wit

2016

Psychoneuroendocrinology

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“…The social separation stress increases spontaneous activity and vocalization of chicks. This social separation-stress paradigm has been used for anxiolytic drug screening, and vocalization and spontaneous activity as the index of the behaviors induced by stressors [13][14][15]. Therefore, to confirm which parts of glutathione are required for sedative and hypnotic effects, the effects of these three peptides, i.e., Glu-Cys, Cys-Gly and Glu-Gly were compared following injection into the brain of neonatal chicks exposed to an isolation-induced stress condition.…”

Section: Introductionmentioning

confidence: 99%

Intracerebroventricular Injection of Glutathione-Related Dipeptides Induces Sedative and Hypnotic Effects During Acute Stress in Neonatal Chicks

Yamane¹,

Suenaga²,

Han³

et al. 2007

LDDD

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To identify the important structural components of glutathione that induce sedative and hypnotic effects, intracerebroventricular (i.c.v.) injection of three glutathione-related dipeptides, i.e., glutamyl-cysteine (Glu-Cys), cysteinyl-glycine (Cys-Gly) and glutamyl-glycine (Glu-Gly) were given during an acute stress condition in neonatal chicks. These peptides attenuated distress vocalizations and spontaneous activity induced by social isolation. The increase in the time for sedation including sleep was also observed following the i.c.v. injection of dipeptides and then the time for active wakefulness decreased. Among the three peptides, Glu-Cys and Glu-Gly had a tendency to attenuate corticosterone release. In conclusion, dipeptides related to glutathione had a sedative and hypnotic effect, and did not vary in their action from each other.

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“…Endogenous opioids strongly influence neuroendocrine, autonomic and behavioral responses to stress in a variety of species (Morris et al, 1990; McCubbin et al, 1993; McCubbin, 1993; Sufka et al, 1994; Janssens et al, 1995; Drolet et al, 2001). These effects are primarily mediated by the inhibitory, G-protein-coupled mu-opioid receptor (μ-OR) (Buckingham & Cooper, 1984; Marson et al, 1989; degli Uberti et al, 1995; Liberzon et al, 2002; Xu et al, 2004; Ribeiro et al, 2005).…”

mentioning

confidence: 99%

Mu-opioid and corticotropin-releasing-factor receptors show largely postsynaptic co-expression, and separate presynaptic distributions, in the mouse central amygdala and bed nucleus of the stria terminalis

Jaferi¹,

Pickel²

2009

Neuroscience

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The anxiolytic effects of opiates active at the mu-opioid receptor (μ-OR) may be ascribed, in part, to suppression of neurons that are responsive to the stress-associated peptide, corticotropin releasing factor (CRF), in the central amygdala (CeA) and bed nucleus of the stria terminalis (BNST). The CRF receptor (CRFr) and μ-OR are expressed in both the CeA and BNST, but their subcellular relationship to each other is not known in either region. To address this question, we used dual electron microscopic immunolabeling of μ-OR and CRFr in the mouse lateral CeA and anterolateral BNST. Immunolabeling for each receptor was detected in the same as well as in separate somatic, dendritic and axonal profiles of neurons in each region. CRFr had a plasmalemmal or cytoplasmic distribution in many dendrites, including those co-expressing μ-OR. The co-expression of CRFr and μ-OR also was seen near excitatory-type synapses on dendritic spines. In both the CeA and BNST, over 50% of the CRFr-labeled dendritic profiles (dendrites and spines) contained immunoreactivity for the μ-OR. However, less than 25% of the dendritic profiles containing the μ-OR were labeled for CRFr in either region, suggesting that opiate activation of the μ-OR affects many neurons in addition to those responsive to CRF. The dendritic profiles containing CRFr and/or μ-OR received asymmetric, excitatory-type synapses from unlabeled or CRFr-labeled axon terminals. In contrast, the μ-OR was identified in terminals forming symmetric, inhibitory-type synapses. Thus, in both the CeA and BNST, μ-OR and CRFr have strategic locations for mediation of CRF and opioid effects on the postsynaptic excitability of single neurons, and on the respective presynaptic release of excitatory and inhibitory neurotransmitters. The commonalities in the synaptic location of both receptors in the CeA and BNST suggest that this is a fundamental cellular association of relevance to both drug addiction and stress-induced disorders. Keywords stress; addiction; relapse; withdrawal; anxiety; electron microscopic immunolabeling *Correspondence to: Dr. Azra Jaferi, Department of Neurology and Neuroscience, Cornell University Medical College, 411 E 69th St, Room KB-410, New York, NY 10021, Tel: (212) 570-2900, ext 326, Fax: (212) 998-3672, E-mail: E-mail: azj2002@med.cornell.edu. Section Editor: Dr. Menahem Segal Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Endogenous opioids strongly influence neuroendocrine, autonomic and behavioral responses to stress in a variety of species (Morris et al, 1990;McCubbin et al, 1993;McCubbin, 1993;Sufk...

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Opiate effects of isolation stress in domestic fowl

Cited by 30 publications

References 31 publications

Effects of buprenorphine on responses to social stimuli in healthy adults

Effects of buprenorphine on responses to social stimuli in healthy adults

Intracerebroventricular Injection of Glutathione-Related Dipeptides Induces Sedative and Hypnotic Effects During Acute Stress in Neonatal Chicks

Mu-opioid and corticotropin-releasing-factor receptors show largely postsynaptic co-expression, and separate presynaptic distributions, in the mouse central amygdala and bed nucleus of the stria terminalis

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