Ophthalmologic Features of Intracranial Chordoma and Allied Tumors of the Clivus

Givner, Isadore

doi:10.1001/archopht.1945.00890170073009

Cited by 25 publications

(4 citation statements)

References 5 publications

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“…In some series, chordomas have involved mainly the left side. 15,20,22 In our cases for which laterality is known, seven chordomas involved mainly the right side and two the left; five had bilateral localizing signs.…”

Section: Discussionmentioning

confidence: 62%

“…'-'3 In contrast, chordomas frequently cause clinical problems by involving cranial nerves, especially those that control extraocular mus- CHORDOMAS OF THE NASAL CAVITY 9 Perzin and Pushparaj 793 Cranial nerve involvement is often found early in the course. 14,15,[19][20][21][22][23] In this respect, chordomas are similar to carcinoma of the nasopharynx, which was the clinical diagnosis in several of our cases before a biopsy was performed.…”

Section: Discussionmentioning

confidence: 99%

“…cles. 14,15,[19][20][21][22][23][24][25][26] area. I4,15,19-26 We could not correlate the clinical course with the histologic appearance of the tumor; the location of the lesion appeared to be a more important factor in prognosis.…”

Section: Discussionmentioning

confidence: 99%

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Nonepithelial tumors of the nasal cavity, paranasal sinuses, and nasopharynx: A clinicopathologic study. XIV: Chordomas

Perzin

Pushparaj

1986

Cancer

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Twenty cases of a rare tumor, chordoma involving the nasal cavity, paranasal sinuses, or nasopharynx, are reported. Patients most often had localized headache, nasal obstruction, decreased hearing, or symptoms related to cranial nerve involvement, especially diplopia. A mass bulging into the nasopharynx, posterior nasal cavity, or pharynx was found on physical examination in 13 of these 20 patients, and in another 6 patients on radiologic examination. Paralysis of one or more cranial nerves was identified in the majority of patients who had tumors involving the upper nasopharynx. On radiologic examination, bone destruction was frequently identified in the clivus and sphenoid areas, and less commonly in the cervical vertebrae. Each patient had biopsy-proven tumor in the nasopharynx or sphenoid areas. Patients usually were treated by combinations of surgery and radiotherapy, in some cases leading to prolonged periods of apparent tumor control. Radiotherapy frequently resulted in regression of symptoms, sometimes lasting many months or years. A few tumors that involved mainly the lower nasopharynx were more amenable to surgical resection, in one case leading to apparent tumor control. In those cases with adequate follow-up information, most patients had either died of their disease or were living with recurrent or persistent inoperable tumor. Some patients lived for many months or years between recurrences or with known tumor, indicating that chordomas often are slowly growing neoplasms. The histologic features of these chordomas are described and illustrated, and the histopathologic differential diagnosis is discussed.

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Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 99%

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Nonepithelial tumors of the nasal cavity, paranasal sinuses, and nasopharynx: A clinicopathologic study. XIV: Chordomas

Perzin

Pushparaj

1986

Cancer

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“…[1][2][3]105,106,109,110,114,[255][256][257] Noninfectious inflammatory causes, such as neurosarcoidosis, Wegener's granulomatosis and Behçet's syndrome, have also been implicated. [1][2][3]258 Head trauma with presumed shearing of multiple cranial nerves, [1][2][3]99,119,123,153,259 base of the skull tumors, particularly along the clivus, [1][2][3][260][261][262][263][264][265][266][267][268][269][270][271][272][273][274][275][276][277][278] and possibly dolichoectatic vasculature 2 may also result in a picture of multiple cranial neuropathies.…”

Section: Abnormalities Of More Than One Ocular Motor Nervementioning

confidence: 99%

Third Nerve Palsies

Biousse¹,

Newman²

2000

Semin Neurol

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The diagnosis and management of third nerve dysfunction varies according to the age of the patient, characteristics of the third nerve palsy, and presence of associated symptoms and signs. Indeed, third nerve palsies may be partial or complete, congenital or acquired, isolated or accompanied by signs of more extensive neurological involvement. They can result from lesions located anywhere from the oculomotor nucleus to the termination of the third nerve in the extra-ocular muscles within the orbit. Recent advances in noninvasive neuroimaging facilitate early diagnosis; however, management of a patient presenting with an isolated third nerve palsy remains a challenge.

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Intracranial Chordoma in Children

Sassin¹,

Chutorian²

1967

Archives of Neurology

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Ophthalmologic Features of Intracranial Chordoma and Allied Tumors of the Clivus

Cited by 25 publications

References 5 publications

Nonepithelial tumors of the nasal cavity, paranasal sinuses, and nasopharynx: A clinicopathologic study. XIV: Chordomas

Nonepithelial tumors of the nasal cavity, paranasal sinuses, and nasopharynx: A clinicopathologic study. XIV: Chordomas

Third Nerve Palsies

Intracranial Chordoma in Children

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