Ophthalmic suspension of Brimonidine for sustained delivery using nano-resin/drug complex technique

Khopade, A. J.; Halder, Arindam; Burade, Vinod; Pateliya, Bharat; Jani, Kaushal; Patel, Vivek; Upadhyay, Sudhaker

doi:10.1016/j.jddst.2022.103594

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…Moreover, the CERs (AmberLite TM IRP69, DIAION TM UBK530, and AmberLite TM IRP69F) in this study possess the structural sulfonate functional group, which is almost completely ionized regardless of solution pH. The pKa of piperadine in PPD was 8.3 and it was ionizable in 0.1 N HCl solution (pH 1.2) used for PCC formation [ 26 , 33 , 34 ].…”

Section: Resultsmentioning

confidence: 99%

Paliperidone–Cation Exchange Resin Complexes of Different Particle Sizes for Controlled Release

et al. 2023

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This study aimed to develop electrolyte complexes of paliperidone (PPD) with various particle sizes using cation-exchange resins (CERs) to enable controlled release (both immediate and sustained release). CERs of specific particle size ranges were obtained by sieving commercial products. PPD–CER complexes (PCCs) were prepared in an acidic solution of pH 1.2 and demonstrated a high binding efficiency (>99.0%). PCCs were prepared with CERs of various particle sizes (on average, 100, 150, and 400 μm) at the weight ratio of PPD to CER (1:2 and 1:4). Physicochemical characterization studies such as Fourier-transform infrared spectroscopy, differential scanning calorimetry, powder X-ray diffraction, and scanning electron microscopy between PCCs (1:4) and physical mixtures confirmed PCC formation. In the drug release test, PPD alone experienced a complete drug release from PCC of >85% within 60 min and 120 min in pH 1.2 and pH 6.8 buffer solutions, respectively. Alternatively, PCC (1:4) prepared with CER (150 μm) formed spherical particles and showed an almost negligible release of PPD in pH 1.2 buffer (<10%, 2 h) while controlling the release in pH 6.8 buffer (>75%, 24 h). The release rate of PPD from PCCs was reduced with the increase in CER particle size and CER ratio. The PCCs explored in this study could be a promising technology for controlling the release of PPD in a variety of methods.

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Section: Resultsmentioning

confidence: 99%