Ophthalmic sequelae and psychosocial impact in pediatric ebola survivors

Shantha, Jessica G.; Canady, Dominick; Hartley, C.D.; Cassedy, Amy; Miller, Chris; Angeles‐Han, Sheila T.; Harrison-Williams, Lloyd; Vandy, Matthew Jusu; Weil, Natalie C.; Bastien, Gilberte; Yeh, Steven

doi:10.1016/j.eclinm.2022.101483

Cited by 5 publications

(5 citation statements)

References 32 publications

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“…In one study where pediatric Ebola survivors and close-contacts were examined, uveitis was observed in 10.8% of Ebola survivors compared to 1.7% of close-contacts ( 21 ). In patients in whom uveitis was identified, vision impairment was observed in a high proportion of individuals.…”

Section: Results/findingsmentioning

confidence: 99%

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Childhood vision impairment and blindness in West Africa: public health measures and implications for systemic health

Yeh,

Huang,

Huang

et al. 2024

Front. Med.

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Childhood blindness is an issue of global health impact, affecting approximately 2 million children worldwide. Vision 2020 and the United Nations Sustainable Development Goals previously identified childhood blindness as a key issue in the twentieth century, and while public health measures are underway, the precise etiologies and management require ongoing investigation and care, particularly within resource-limited settings such as sub-Saharan Africa. We systematically reviewed the literature on childhood blindness in West Africa to identify the anatomic classification and etiologies, particularly those causes of childhood blindness with systemic health implications. Treatable causes included cataract, refractive error, and corneal disease. Systemic etiologies identified included measles, rubella, vitamin A deficiency, and Ebola virus disease. While prior public health measures including vitamin A supplementation and vaccination programs have been deployed in most countries with reported data, multiple studies reported preventable or reversible etiologies of blindness and vision impairment. Ongoing research is necessary to standardize reporting for anatomies and/or etiologies of childhood blindness to determine the necessity of further development and implementation of public health measures that would ameliorate childhood blindness and vision impairment.

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Section: Results/findingsmentioning

confidence: 99%

“…Shantha et al assessed vision impairment in a cross-sectional study of EVD survivors or close-contact control patients at the Lowell and Ruth Gess Eye Hospital in Sierra Leone ( 21 ). Eighty-one pediatric patients were evaluated for visual acuity, eye disease, and quality-of-life changes.…”

Section: Results/findingsmentioning

confidence: 99%

Childhood vision impairment and blindness in West Africa: public health measures and implications for systemic health

Yeh,

Huang,

Huang

et al. 2024

Front. Med.

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“…Indeed, previous studies among adults in the same region found that living in rural areas was associated with different mental health problems. [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] The findings of the present study could be explained by reduced access to information on EVD in rural settings, which can lead to increased EVD-related stigma. 40 Indeed, a recent scoping review on EVD prevention measures showed that access to information is a major key in preventing EVD-related stigma.…”

Section: Discussionmentioning

confidence: 99%

“… 17 Second, a study demonstrated that youth EVD survivors experienced higher scores of depression and anxiety than youth with close contact with EVD patients. 20 The prevalence and factors associated with mental health problems have not been studied in the DRC or elsewhere.…”

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confidence: 99%

Prevalence and determinants of anxiety, depression and comorbid anxiety–depression symptoms among adolescents in Ebola-affected zones

Cénat,

Dromer,

Mistry

et al. 2023

BJPsych open

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Background Ebola virus disease (EVD) has been shown to be associated with poor mental health in affected zones. However, no study has yet explored its impact on adolescents’ mental health. Aims This study aimed to assess the prevalence and risk factors associated with depression and anxiety symptoms among adolescents in EVD-affected areas in the Equateur Province of the Democratic Republic of the Congo during the COVID-19 pandemic. Method A provincial sample of adolescents aged 12–17 years (M = 14.84, s.d. = 1.49) living in the 18 urban and rural areas affected by the 2018 EVD outbreak completed a two-wave longitudinal survey. Surveys assessed symptoms of depression and anxiety, exposure to Ebola, social support and sociodemographic information. Results A total of 490 participants completed the baseline and follow-up surveys, 50% of whom were female. Elevated and worsened depressive symptoms were observed among participants from the baseline (56.94%) to the follow-up (91.43%; z = −11.37, P < 0.001), whereas anxiety symptoms decreased from the baseline (36.33%) to follow-up (24.90%; z = 4.06, P < 0.001). The final generalised estimating equation model showed that anxiety symptoms decreased over time (B = −3.92, P < 0.001), while depression symptoms increased (B = 4.79, P < 0.001). Stigmatisation related to Ebola positively predicted anxiety (B = 5.41, P < 0.001) and depression symptoms (B = 0.4452, P = 0.009). Social support negatively predicted anxiety (B = −1.13, P = 0.004) and depression (B = −0.98, P < 0.001) symptoms but only moderated the association between stigmatisation and depression symptoms (B = −0.67, P < 0.001). Conclusions Most adolescents living in EVD-affected areas experience mental health issues. Stigmatisation related to EVD and living in urban areas are the most consistent predictors of mental health problems. Nevertheless, social support remains a protective factor for depression and anxiety symptoms and a necessary resource for building resilience.

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“… 9 One cohort study reported high incidence of ophthalmic complications in the pediatric EVD survivors as compared to the close contact population. 10 In addition, there is mounting evidence of long-term EBOV persistence in immune-privileged sites including the eyes, CNS, and male reproductive tract among EVD survivors, which complicates treatment. 11 This includes a patient who recovered from acute EVD and yet had replicating virus in the aqueous humor 14 weeks after the onset of the disease and 9 weeks after the clearance of viremia, leading to severe unilateral uveitis during convalescence.…”

Section: Introductionmentioning

confidence: 99%

Ebola virus-induced eye sequelae: a murine model for evaluating glycoprotein-targeting therapeutics

Lee,

Xu,

Lewkowicz

et al. 2024

eBioMedicine

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Ophthalmic sequelae and psychosocial impact in pediatric ebola survivors

Cited by 5 publications

References 32 publications

Childhood vision impairment and blindness in West Africa: public health measures and implications for systemic health

Childhood vision impairment and blindness in West Africa: public health measures and implications for systemic health

Prevalence and determinants of anxiety, depression and comorbid anxiety–depression symptoms among adolescents in Ebola-affected zones

Ebola virus-induced eye sequelae: a murine model for evaluating glycoprotein-targeting therapeutics

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