Ophthalmic Presentation in the Emergency Department: A Case Report of a Girl With “Shimmering Eyes”

Krivochenitser, R.; Lemma, Yonatan; Wynn, Barbara N.; Jones, J. Stephen

doi:10.1016/j.jemermed.2014.01.031

Cited by 2 publications

(4 citation statements)

References 12 publications

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“…The association between the mean age of the Neuroblastoma patients and ophthalmologic manifestation according to our analysis of 65 case reports and Musarella et al8–10,12–14,16–18,21–37,44–73 HS indicates Horner syndrome; OMS, opsoclonus-myoclonus syndrome. *Statistical significance.…”

Section: Case Reports Analysismentioning

confidence: 87%

“…The incidence of the primary tumor localization in patients diagnosed with neuroblastoma, ganglioneuroblastoma, and ganglioneuroma according to the 84 analyzed case reports 9,10,12–14,16–18,21–31,33–39,44–53,55–62,64–66,68–79,81–84. AM indicates adrenal medulla; GN, ganglioneuroma; GNBL, ganglioneuroblastoma; NBL, neuroblastoma.…”

Section: Case Reports Analysismentioning

confidence: 99%

“…The incidence of opsoclonus-myoclonus syndrome and the associated symptoms in 68 children diagnosed with neuroblastoma, and 16 patients with ganglioneuroblastoma. Overall, there were 29 cases of opsoclonus-myoclonus syndrome 9,10,12–14,16–18,21–39,44–80. OMS indicates opsoclonus-myoclonus syndrome.…”

Section: Case Reports Analysismentioning

confidence: 99%

“…The proportion of children who achieved opsoclonus-myoclonus syndrome remission and of the residual disorders in patients diagnosed with neuroblastoma and ganglioneuroblastoma. The data were accessible from 13 case reports 23,46,52,56,59,66,72,77,80…”

Section: Case Reports Analysismentioning

confidence: 99%

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Ophthalmologic Manifestations of Neuroblastoma: A Systemic Review

Kuchalska

Derwich²,

Gotz‐Więckowska

2022

Journal of Pediatric Hematology/Oncology

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Neuroblastoma (NBL) is the most common extracranial solid tumor found in pediatric patients. It develops from the sympathetic tract tissue. Although the symptoms are associated with tumor localization, sometimes NBL is manifested as ophthalmologic disorders. In this paper, we describe their incidence and the correlation with the prognosis. We searched 2 databases (PubMed and Web of Science) for papers published before April 2022, and concerned pediatric patients with NBL, which caused ophthalmologic changes. We collected 7 papers assessing the occurrence of ophthalmologic findings in the NBL patients, as well as 68 case reports presenting children with orbital changes and NBL, or with other tumors stemming from the sympathetic ganglia. The statistical analysis was performed to synthetize the data. The ophthalmologic signs occurred in 17.89% of the NBL cases; however, they were observed on presentation in 10.68%. The isolated ocular presentation was found in 2.56% of patients, whereas Horner syndrome was most frequent. The ophthalmologic symptoms correlated with patients’ age, primary tumor site, and survival rate. NBL may be challenging to diagnose in cases with isolated ophthalmologic manifestations. Numerous possible ocular signs can be observed, which emphasize the need for multidisciplinary care with regard to the NBL patients.

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Section: Case Reports Analysismentioning

confidence: 87%

Section: Case Reports Analysismentioning

confidence: 99%

Section: Case Reports Analysismentioning

confidence: 99%

Section: Case Reports Analysismentioning

confidence: 99%

See 2 more Smart Citations

Ophthalmologic Manifestations of Neuroblastoma: A Systemic Review

Kuchalska

Derwich²,

Gotz‐Więckowska

2022

Journal of Pediatric Hematology/Oncology

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Comparison of mediastinal and non-mediastinal neuroblastoma and ganglioneuroblastoma associated with opsoclonus-myoclonus syndrome: a systematic review and meta-analysis

Xie¹,

Bai²,

Li³

et al. 2022

Transl Cancer Res TCR

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Background: Neuroblastoma is the most common malignancy in children younger than seven years of age and is the most frequent extracranial solid tumor that occurs in childhood. While opsoclonus-myoclonus syndrome (OMS), a paraneoplastic neurologic syndrome, affects 2-3% of children with neuroblastoma, and the percentage of mediastinal localization of the tumor is 49%. The objective of this study was to identify and characterize features of the OMS syndrome and treatments of mediastinal and non-mediastinal neuroblastoma associated with OMS.Methods: A systematic review of the literature was performed using PubMed, Medline, Web of Science, Embase and Cochrane. The search has no limit on date with the last search done on Dec 31, 2020. There is no publication restrictions or study design filters applied in the search.Results: Fifty-five out of 242 papers were identified and met our study eligibility. There were 77 cases found (28 cases had Mediastinal neuroblastoma, and 49 cases had non-mediastinal neuroblastoma). Data from trials showed that cases with mediastinal neuroblastoma who seemed to have undergone less treatment for OMS [rate ratio (RR) 0.41 (95% CI: 0.22-0.76)] had resulted in decreasing persistent neurologic symptoms [RR 0.31 (95% CI: 0.10-0.96)].Conclusions: Children who have OMS and mediastinal neuroblastoma may be associated with more favorable clinical and biological characteristics and better outcomes than children who have OMS and nonmediastinal neuroblastoma, and they are more likely to present with a single neurological symptom at first.The OMS in mediastinal neuroblastoma might also be treated effectively through resection of the tumor followed by appropriate radiotherapy and chemotherapy, and no long-term treatments of OMS is indicated.

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Ophthalmic Presentation in the Emergency Department: A Case Report of a Girl With “Shimmering Eyes”

Cited by 2 publications

References 12 publications

Ophthalmologic Manifestations of Neuroblastoma: A Systemic Review

Ophthalmologic Manifestations of Neuroblastoma: A Systemic Review

Comparison of mediastinal and non-mediastinal neuroblastoma and ganglioneuroblastoma associated with opsoclonus-myoclonus syndrome: a systematic review and meta-analysis

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