Ophthalmic Manifestations in Chronic Inflammatory Rheumatic Diseases at a Referral Hospital of Yaounde, Cameroon

Noche, Christelle Domngang; Kagmeni, Giles; Dohvoma, VA; Bella, Assumpta Lucienne; Mvogo, Côme Ebana; Singwé–Ngandeu, Madeleine

doi:10.1080/09273948.2016.1212078

Cited by 12 publications

(5 citation statements)

References 21 publications

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“…In contrast, Africa was poorly represented, with only two small studies. 29,40 This is likely to reflect the existing SLE literature as a whole. Similarly, the ethnicity of patients was under-reported in the studies.…”

Section: Discussionmentioning

confidence: 94%

Epidemiology of disease-activity related ophthalmological manifestations in Systemic Lupus Erythematosus: A systematic review

Jawahar¹,

Walker²,

Murray

et al. 2021

Lupus

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Objective Ophthalmic complications in Systemic Lupus Erythematosus (SLE) are broad and can occur in up to a third of patients. The British Isles Lupus Assessment Group (BILAG) 2004 Index identifies 13 ocular manifestations of active SLE, as opposed to those related to previous disease activity and/or the consequences of therapy. We conducted a systematic review of published literature to determine the frequency of ophthalmic manifestations of active SLE. Methods A systematic literature search of Ovid MEDLINE and EMBASE from their respective inceptions to July 2020 was conducted to identify cohort, case–control and cross-sectional studies. Results 22 studies meeting eligibility criteria were included. Most studies featured small sample sizes and were judged to have a high risk of methodological bias. The number and quality of studies did not allow us to confidently estimate the incidence of the conditions. No studies reported epidemiological data for orbital inflammation/myositis/proptosis. The prevalence of each of the other ocular manifestations, with the exception of retinal vaso-occlusive disease, was consistently less than 5%. Retinal vasculitis, uveitis and isolated cotton wool spots tended to be associated with more active SLE disease. Conclusion The prevalence of eye disease due to SLE activity is uncommon, but clinicians should be aware that some conditions tend to be associated with more active systemic disease. Further studies to determine the incidence and risk factors for these ophthalmic manifestations are needed.

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Section: Discussionmentioning

confidence: 94%

Epidemiology of disease-activity related ophthalmological manifestations in Systemic Lupus Erythematosus: A systematic review

Jawahar¹,

Walker²,

Murray

et al. 2021

Lupus

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“…Patients with PsA had significantly increased body mass index, waist circumference, and hip circumference vs. those with seropositive RA but not seronegative RA [ 35 ]. Anterior uveitis was exclusively observed in patients with AS vs. RA [ 53 ]. Patients with RA presented with worse mean hand grip strength than those with PsA [ 42 , 58 ].…”

Section: Resultsmentioning

confidence: 99%

“…Based on PRO measures, the burden of disease was relatively equal between SpA and RA. While some studies did examine HLA-B27 as a laboratory measure in their patient population [ 24 – 26 , 53 , 55 , 65 , 69 , 78 ], no comparisons were made between SpA and RA. As genetic and other biomarker assays become more validated as diagnostic tools to differentiate between specific disease states, this will hopefully address and potentially resolve some of the challenges associated with diagnosis highlighted here.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Clinical Manifestations in Rheumatoid Arthritis vs. Spondyloarthritis: A Systematic Literature Review

et al. 2021

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Introduction: Misclassification of spondyloarthritis (SpA) as rheumatoid arthritis (RA) may lead to delayed SpA diagnosis and suboptimal therapeutic outcomes. Here, we evaluate the literature on clinical manifestations in patients with SpA and RA, particularly seronegative RA, to understand the potential overlap, distinctions, and most reliable approaches to accurate diagnosis. Methods: In this systematic literature review, conducted according to PRISMA guidelines, we searched key biomedical databases for Englishlanguage publications of original research articles (up to July 23, 2020) and rheumatology conference abstracts (January 1, 2018-July 31, 2020) reporting key SpA clinical presentations in patients with SpA or RA. Publications were assessed for eligibility by two independent reviewers; discrepancies were resolved by a third. Studies were evaluated for publication quality using the Downs and Black checklist. Results: Of 4712 records retrieved, 79 met the inclusion criteria and were included in the analysis. Of these, 54 included study populations with SpA and RA, and 25 with seropositive and/or seronegative RA. Entheseal abnormalities were more frequently reported among patients with SpA than RA and with seronegative vs. seropositive RA. Psoriasis, nail psoriasis, and dactylitis were exclusively seen in SpA vs. RA. In most publications (70 of 79), advanced imaging techniques allowed for more accurate distinction between SpA and RA. Overlapping clinical characteristics occur in SpA and RA, including inflammation and destruction of joints, pain, diminished functional ability, and increased risk for comorbidities. However, of 54 studies comparing SpA and RA populations, only seven concluded that no distinction can be

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“…Ocular manifestations seen in lupus are usually not specific to the disease and can be found in other autoimmune-related diseases such as rheumatoid arthritis, reactive arthritis, primary Sjogren's syndrome, multiple sclerosis, neuromyelitis optica, etc. [26][27][28][29][30]. In fact, systemic conditions like collagen vascular disorders are also implicated in the pathogenesis of SLE [31].…”

Section: Multidisciplinary Diagnosismentioning

confidence: 99%

Unveiling Ocular Manifestations in Systemic Lupus Erythematosus

Musa,

Chukwuyem,

Ojo

et al. 2024

JCM

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Systemic Lupus Erythematosus (SLE) is a complex autoimmune disorder characterized by immune dysregulation and multi-organ involvement. In this concise brief review, we highlight key insights into Ocular Systemic Lupus Erythematosus (SLE), an intricate autoimmune disorder with diverse organ involvement. Emphasizing the formation of autoantibodies and immune complex deposition, we delve into the inflammation and damage affecting ocular structures. Clinical presentations, ranging from mild dry eye syndrome to severe conditions like retinal vasculitis, necessitate a comprehensive diagnostic approach, including clinical exams, serological testing, and imaging studies. Differential diagnosis involves distinguishing SLE-related ocular manifestations from other autoimmune and non-inflammatory ocular conditions. The multidisciplinary management approach, involving rheumatologists, ophthalmologists, and immunologists, tailors treatment based on ocular involvement severity, encompassing corticosteroids, immunosuppressive agents, and biologics. Follow-up is crucial for monitoring disease progression and treatment response. Future perspectives revolve around advancing molecular understanding, refining diagnostic tools, and exploring targeted therapies. Novel research areas include genetic factors, microbiome composition, and biotechnology for tailored and effective SLE ocular treatments.

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Ophthalmic Manifestations in Chronic Inflammatory Rheumatic Diseases at a Referral Hospital of Yaounde, Cameroon

Abstract: Ocular manifestations occurred in 61.1% of CIRD. Dry eye syndrome and anterior uveitis were commonly observed.

Cited by 12 publications

References 21 publications

Epidemiology of disease-activity related ophthalmological manifestations in Systemic Lupus Erythematosus: A systematic review

Epidemiology of disease-activity related ophthalmological manifestations in Systemic Lupus Erythematosus: A systematic review

Comparison of Clinical Manifestations in Rheumatoid Arthritis vs. Spondyloarthritis: A Systematic Literature Review

Unveiling Ocular Manifestations in Systemic Lupus Erythematosus

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