Ophthalmic involvement of chronic lymphocytic leukemia: A systematic review of 123 cases

Delestre, Fabienne; Blanche, P.; Bouayed, E.; Bouscary, Didier; Mouthon, Luc; Brézin, Antoine P.; Jeunne, Claire Le; Chaigne, Benjamin

doi:10.1016/j.survophthal.2020.05.001

Cited by 13 publications

(18 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…6 Nevertheless, it is acknowledged that anterior uveitis has been reported as a manifestation of CLL in a minority of patients. 7 It is most often caused by leukaemic infiltrates resulting in a masquerade syndrome, usually with poor response to topical steroids. However, anterior segment changes are most commonly associated with posterior segment involvement, as vitreo-retinal, choroidal and optic nerve leukaemic infiltration.…”

Section: Discussionmentioning

confidence: 99%

“…4 Pseudo-hypopyon, a classic masquerade syndrome sign, is usually a result of a blast crisis, mainly in acute leukaemia or high-grade transformations, and not CLL. 7 Hyperviscosity-related ocular changes are also rarely described in CLL, even in patients with high white blood cell counts. 8 On the contrary, both of our patients were systemically well, under regular monitoring by their haematologists with stable disease.…”

Section: Np96mentioning

confidence: 99%

See 1 more Smart Citation

Ibrutinib-related uveitis: A report of two severe cases

Bohn

Bravo-Ljubetic

Lee

et al. 2021

European Journal of Ophthalmology

View full text Add to dashboard Cite

Introduction: Ibrutinib is a small-molecule drug approved for the treatment of haematological disorders and is known to be associated with visual disturbances, but uveitis has not yet been reported as an adverse effect of this medication. We present two cases of ibrutinib-associated severe uveitis in patients with chronic lymphocytic leukaemia. Case description: Our first case is a 65-year-old woman who presented with acute onset of bilateral fibrinous anterior uveitis 1 day after starting ibrutinib. Her vision was hand movements in the right eye and 20/120 in the left with hyperaemic discs and subretinal fluid. Ibrutinib was stopped and she experienced a significant improvement under local and oral steroid treatment. The second case is a 64-year-old male with subacute onset of bilateral hypertensive anterior uveitis with pupillary seclusion and right eye hyphaema. He was on ibrutinib for the past 9 months. His vision at presentation was 20/80 and 20/60 for the right and left eye, respectively. He responded poorly to local steroid treatment until ibrutinib was stopped due to cardiac side-effects, after which his uveitis resolved and treatment was stopped. Conclusion: The temporal association between changes in ibrutinib treatment and our patients’ ocular inflammation suggests a causative link. Ibrutinib increases Th1-based immune responses which is proposed as a mechanism for drug-induced uveitis. Its antiplatelet effect may explain the fibrinous nature of the inflammation and hyphaema.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Np96mentioning

confidence: 99%

Ibrutinib-related uveitis: A report of two severe cases

Bohn

Bravo-Ljubetic

Lee

et al. 2021

European Journal of Ophthalmology

View full text Add to dashboard Cite

show abstract

“…In our patient with leukocytosis of monoclonal lymphocytes (CLL), the hematoma contained this same type of cellular component. No tissue involvement by infiltrating monoclonal lymphocytes was identified, which is not common in literature reports of patients with CNS involvement of CLL 5 Although rare, CNS involvement by CLL or SLL can present with diplopia or other neurologic symptoms and signs. However, while there have been many reports and retrospective reviews including patients with diplopia from CLL, this is typically from direct leukemic infiltration and not owing to the presence of hemorrhagic lesions, as in our case.…”

Section: Q3mentioning

confidence: 70%

“…However, while there have been many reports and retrospective reviews including patients with diplopia from CLL, this is typically from direct leukemic infiltration and not owing to the presence of hemorrhagic lesions, as in our case. 5 cavernous malformations rather than hemorrhagic CLL involvement. Surgical exploration and histopathology of the lesion demonstrated the hematoma containing CLL.…”

Section: Q3mentioning

confidence: 95%

Central nervous system hemorrhage due to chronic lymphocytic leukemia

Raviskanthan

Hall

Mortensen

et al. 2022

Canadian Journal of Ophthalmology

View full text Add to dashboard Cite

show abstract

“…2 Approximately 60% to 65% of patients are asymptomatic at the time of diagnosis. 3 Transformation of CLL in an aggressive lymphoma occurs at a rate of 0.5% to 1% per year. 1 Ocular manifestations may present as the initial manifestation of disease or the sole site of disease relapse.…”

mentioning

confidence: 99%