Ophthalmic delivery of Cyclosporine A from Brij-97 microemulsion and surfactant-laden p-HEMA hydrogels

Kapoor, Yash; Chauhan, Anuj

doi:10.1016/j.ijpharm.2008.05.028

Cited by 108 publications

(60 citation statements)

References 35 publications

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“…the artificial cornea (15), and to produce controlled drug delivery systems (12, 16,17). Their highly porous structure can easily be tuned by controlling the density of cross-links in the gel matrix, the affinity of the hydrogels for the aqueous environment in which they are swollen, and also allows drug loading into the gel matrix for subsequent drug release at a rate dependent on the diffusion coefficient of the drug through the gel network (13).…”

Section: Hydrogelsmentioning

confidence: 99%

“…Many methods have been developed to modify the conventional contact lenses to improve their drug loading and release (16,52,(60)(61)(62)(63)(64)(65). The use of a device from which a drug may diffuse can improve the contact time of the drug with its target tissue.…”

Section: Soft Contact Lenses For Ocular Drug Delivery and Strategies mentioning

confidence: 99%

“…Several methods have been proposed to achieve an extended and controlled release of ocular therapeutics via contact lenses such as carrier-mediated release and surfactant mediated release (16,61 (78). Cyclosporine (Cyc) is an immunosuppressant drug that has been used for treatment of various ocular diseases.…”

Section: Soft Contact Lenses For Ocular Drug Delivery and Strategies mentioning

confidence: 99%

“…Cyclosporine (Cyc) is an immunosuppressant drug that has been used for treatment of various ocular diseases. Kapoor and Chauhan showed that pHEMA hydrogels loaded with Brij 98, a surfactant, and Cyc, exhibited an extended release of the drug, and they conclude that contact lenses made with this material could be used for ocular delivery of Cyc (16,61). More recently, molecular imprinting design approaches have been applied to maximize the affinity of a network for some ocular drugs.…”

Section: Soft Contact Lenses For Ocular Drug Delivery and Strategies mentioning

confidence: 99%

See 3 more Smart Citations

Improvements in Topical Ocular Drug Delivery Systems: Hydrogels and Contact Lenses

Ribeiro¹,

Figueiras²,

Veiga³

2015

J Pharm Pharm Sci

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-Purpose. Conventional ophthalmic systems present very low corneal systemic bioavailability due to the nasolacrimal drainage and the difficulty to deliver the drug in the posterior segment of ocular tissue. For these reasons, recent advances have focused on the development of new ophthalmic drug delivery systems. This review provides an insight into the various constraints associated with ocular drug delivery, summarizes recent findings in soft contact lenses (SCL) and the applications of novel pharmaceutical systems for ocular drug delivery. Among the new therapeutic approaches in ophthalmology, SCL are novel continuous-delivery systems, providing high and sustained levels of drugs to the cornea. The tendency of research in ophthalmic drug delivery systems development are directed towards a combination of several technologies (bio-inspired and molecular imprinting techniques) and materials (cyclodextrins, surfactants, specific monomers). There is a tendency to develop systems which not only prolong the contact time of the vehicle at the ocular surface, but also at the same time slow down the clearance of the drug. Different materials can be applied during the development of contact lenses and can be combined with natural inspired strategies of drug immobilization and release, providing successful tools for ocular drug delivery systems.

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Section: Hydrogelsmentioning

confidence: 99%

Section: Soft Contact Lenses For Ocular Drug Delivery and Strategies mentioning

confidence: 99%

Section: Soft Contact Lenses For Ocular Drug Delivery and Strategies mentioning

confidence: 99%

Section: Soft Contact Lenses For Ocular Drug Delivery and Strategies mentioning

confidence: 99%

See 2 more Smart Citations

Improvements in Topical Ocular Drug Delivery Systems: Hydrogels and Contact Lenses

Ribeiro¹,

Figueiras²,

Veiga³

2015

J Pharm Pharm Sci

View full text Add to dashboard Cite

show abstract

“…Multifunctional nanoemulsions for oral and intravenous delivery: Gadolinium-loaded nanoemulsion has been utilized for brain imaging in animal studies [114][115][116][117][118][119][120][121][122][123][124][125][126][127][128][129][130][131][132][133]134]. This imaging technology could be utilized for imaging within the eye to observe the results of various drug delivery modalities.…”

Section: Applications Of Nanoparticulate Transscleral Drug Delivery Smentioning

confidence: 99%

Nanoparticulate Transscleral Ocular Drug Delivery

Shah¹,

Shah²,

Groshev³

et al. 2014

J Biomol Res Ther

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Ocular drug delivery is one of the most challenging areas of drug delivery due to the unique mostly avascular nature of the major eye structures and presence of two blood barriers. Effectiveness of a more conventional systemic delivery falls short due to low drug levels in the eye tissue. Periocular approaches require penetration of fibrous sclera and present their own limitations. Utilization of nanotechnology presents new avenue of drug system development with potential to penetrate protective barriers and sustain ample tissue saturation. More specifically, transscleral delivery permits a range of applications in targeted delivery, gene, stem cell, protein and peptides, oligonucleotide, and ribozyme therapies. The exciting range of current applications is expounded in this review.

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Injectable in situ Gelling Hydrogels as Biomaterials

Singh

Nair

2012

Integrated Biomaterials for Biomedical Technology

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Ophthalmic delivery of Cyclosporine A from Brij-97 microemulsion and surfactant-laden p-HEMA hydrogels

Cited by 108 publications

References 35 publications

Improvements in Topical Ocular Drug Delivery Systems: Hydrogels and Contact Lenses

Improvements in Topical Ocular Drug Delivery Systems: Hydrogels and Contact Lenses

Nanoparticulate Transscleral Ocular Drug Delivery

Injectable in situ Gelling Hydrogels as Biomaterials

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