Ophthalmic complications of childhood medulloblastoma

Cassidy, Lorraine; Stirling, R J; May, Kristina; Picton, Susan; Doran, R. M. L.

doi:10.1002/(sici)1096-911x(200001)34:1<43::aid-mpo8>3.0.co;2-h

Cited by 20 publications

(2 citation statements)

References 15 publications

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“…Motor and sensory deficits including paralysis, movement disorders, and ataxia may impair mobility and create a risk for falls. Other problems such as seizures, eye problems (eg, ocular nerve palsy, nystagmus, papilledema, and optic atrophy), hydrocephalus/shunt malfunctions, and spinal cord damage (eg, neurogenic bladder/bowel, incontinency) have also been reported (Cassidy, Stirling, May, Picton, & Doran, 2000;Khan et al, 2005;Khan, Boop, Onar, & Sanford, 2006;Khan, Marshman, & Mulhern, 2003;McGirt et al, 2008). Neurocognitive dysfunction is expressed as learning deficiencies, diminished IQ, and behavioral changes.…”

Section: Neurological and Neurocognitive Late Effectsmentioning

confidence: 99%

Transitioning Survivors of Central Nervous System Tumors: Challenges for Patients, Families, and Health Care Providers

Eshelman-Kent

Gilger

Gallagher

2009

J Pediatr Oncol Nurs

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Survivors of central nervous system tumors (SCNST) are a growing group of cancer survivors who require risk-based, long-term health care due to the chemotherapy, surgery, and radiation they have received.Although treatment strategies are being developed to reduce morbidity and mortality, ultimately this subgroup of pediatric cancer survivors often faces moderate to severe late effects of their treatment.As a result, they will need lifelong health care that includes risk-based health care due to cancer treatment exposures as well as primary adult health care, including primary and secondary preventative care. The best way to accomplish lifelong health care for SCNST as they enter adulthood is not clearly defined. In this article, the authors plan to (1) present an overview of the complexities of health care problems that make transition challenging for SCNST; (2) review the evolving transition literature; (3) explore the barriers to successful transition; (4) discuss methods to facilitate transition; (5) describe approaches, strategies, and models for survivorship care in SCNST; (6) present issues for consideration when transitioning SCNST; and (7) provide information on transition-related resources.

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Section: Neurological and Neurocognitive Late Effectsmentioning

confidence: 99%

Transitioning Survivors of Central Nervous System Tumors: Challenges for Patients, Families, and Health Care Providers

Eshelman-Kent

Gilger

Gallagher

2009

J Pediatr Oncol Nurs

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“…In addition, MB frequently causes the disorders of cerebrospinal fluid (CSF) circulation, which requires immediate treatment, including drainage by surgical implantation of the CSF shunt system ( 9 ). Other manifestations, depending on the localization of the primary tumor and metastases, are uncoordinated movements, cranial nerves palsy, nystagmus, diplopia, and restricted eye movements ( 10 , 11 ).…”

Section: Introductionmentioning

confidence: 99%

Case Report: Primary Leptomeningeal Medulloblastoma in a Child: Clinical Case Report and Literature Review

et al. 2022

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Medulloblastoma is one of the most common pediatric central nervous system malignancies worldwide, and it is characterized by frequent leptomeningeal metastasizing. We report a rare case of primary leptomeningeal medulloblastoma of an 11-year-old Caucasian girl with a long-term disease history, non-specific clinical course, and challenges in the diagnosis verification. To date, 4 cases of pediatric primary leptomeningeal medulloblastoma are reported, and all of them are associated with unfavorable outcomes. The approaches of neuroimaging and diagnosis verification are analyzed in the article to provide opportunities for effective diagnosis of this disease in clinical practice. The reported clinical case of the primary leptomeningeal medulloblastoma is characterized by MR images with non-specific changes in the brain and spinal cord and by 18FDG-PET/CT images with diffuse heterogeneous hyperfixation of the radiopharmaceutical along the whole spinal cord. The immunohistochemistry and next-generation sequencing analyses of tumor samples were performed for comprehensive characterization of the reported clinical case.

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Optic Atrophy in Children

Brodsky

2009

Pediatric Neuro-Ophthalmology

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Ophthalmic complications of childhood medulloblastoma

Cited by 20 publications

References 15 publications

Transitioning Survivors of Central Nervous System Tumors: Challenges for Patients, Families, and Health Care Providers

Transitioning Survivors of Central Nervous System Tumors: Challenges for Patients, Families, and Health Care Providers

Case Report: Primary Leptomeningeal Medulloblastoma in a Child: Clinical Case Report and Literature Review

Optic Atrophy in Children

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