Ophthalmic Artery Morphological and Hemodynamic Features in Acute Coronary Syndrome

Wu, Lan-Ting; Wang, Jialin; Wang, Yanling

doi:10.1167/iovs.62.14.7

Cited by 8 publications

(19 citation statements)

References 35 publications

(26 reference statements)

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“…Such inconsistencies may be related to different measurement techniques, locations, and differences in patient population characteristics [ 9 – 11 ]. After blood simulation, we found that the OA blood velocity in patients with ACS was relatively low, which is consistent with the results of our previous study [ 16 ]. In this study, the blood velocity in patients with T2D only was lower than that in the control group, but it was higher than that in both ACS groups.…”

Section: Discussionsupporting

confidence: 91%

“…We reviewed the electronic medical records of patients with ACS and T2D who underwent head and neck CTA in Beijing Friendship Hospital from September 2021 to February 2022 and of healthy individuals who underwent CTA for other reasons. The CTA acquisition method was the same as that in our previous study [ 16 ]. All patients had a clear diagnosis.…”

Section: Methodsmentioning

confidence: 99%

“…The method of OA 3D model reconstruction and blood flow simulation was similar to that used in our previously published study [ 16 ]. The Digital Imaging and Communications in Medicine images of the head and neck CTA were imported into Mimics 21.0 (Materialise, Ann Arbor, MI, USA).…”

Section: Methodsmentioning

confidence: 99%

“…We previously reconstructed three-dimensional (3D) OA models and adopted CFD numerical simulations to examine the morphological and hemodynamic features of OA in patients with ACS and found a slower blood velocity [ 16 ]. Based on the previous study, the current study aimed to explore the morphological and hemodynamic characteristics of the OA in patients with T2D, with or without ACS, and to assess the correlation between OA characteristics and clinical indicators.…”

Section: Introductionmentioning

confidence: 99%

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Ophthalmic artery changes in type 2 diabetes with and without acute coronary syndrome

Wang

2022

J Transl Med

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Background Ocular blood flow provides a new perspective for studying the effects of diabetes and ischemic heart disease on systemic blood flow, pathological mechanisms, and prognosis. Previous studies have analyzed the hemodynamic changes of the ophthalmic artery (OA) in patients with diabetes and ischemic heart disease, but the results remain controversial due to limited observation methods. We aimed to explore the morphological and hemodynamic features in the OA in patients with type 2 diabetes (T2D) with and without acute coronary syndrome (ACS). Methods In total, 134 participants, including 30 control participants, 34 with ACS only, 34 with T2D only, and 36 with both ACS and T2D, undergoing computed tomography angiography were enrolled. Three-dimensional OA models were reconstructed, and morphological parameters of the OA were measured. In addition, numerical simulations using computational fluid dynamics were used to acquire hemodynamic parameters of the OA. Results In this study, 134 OA models were reconstructed. Morphological measurements revealed a smaller initial OA diameter in the T2D group than in the other two ACS groups. A hemodynamic simulation showed a significantly lower OA blood velocity in patients with ACS and T2D than that in controls (P < 0.001). The mass flow ratios in all disease groups were lower than those in the control group (P < 0.001, P = 0.020, and P < 0.001, respectively). The ACS and T2D groups had higher OA pressure levels than those of the control group (P = 0.013). The OA blood velocity and mass flow ratio were correlated with several clinical parameters. Conclusions This study revealed morphological and hemodynamic differences in the OA between patients with T2D with and without ACS. Furthermore, the hemodynamic characteristics of the OA correlated with clinical prognostic biomarkers, suggesting the potential predictive ability of the OA.

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Section: Discussionsupporting

confidence: 91%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ophthalmic artery changes in type 2 diabetes with and without acute coronary syndrome

Wang

2022

J Transl Med

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“…Most current studies have focused on the retinal microvasculature, which is easily affected by hypertension and diabetes mellitus. The OA was thought to directly reflect ocular blood flow [ 9 ]. Therefore, it is critical to analyze the correlation between CSVD signs and OA hemodynamics.…”

Section: Introductionmentioning

confidence: 99%

Impact of total cerebral small vessel disease score on ophthalmic artery morphologies and hemodynamics

et al. 2023

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Background Cerebral small vessel disease (CSVD) is a systemic disease, affecting not only the brain, but also eyes and other organs. The total CSVD score is a tool for comprehensive evaluation of brain lesions in patients with CSVD. The ophthalmic artery (OA) is a direct response to ocular blood flow. However, little is known about the correlation between CSVD and characteristics of OA. We investigated the OA morphologies and hemodynamics in patients with CSVD and the correlation between these changes and the total CSVD score. Methods This cross-sectional observational study included 34 eyes from 22 patients with CSVD and 10 eyes from 5 healthy controls. The total CSVD score was rated according to the CSVD signs on magnetic resonance imaging. OA morphological characteristics were measured on the basis of 3D OA model reconstruction. OA hemodynamic information was calculated using computational fluid dynamics simulations. Results The total CSVD score negatively correlated with the OA diameter, blood flow velocity, and mass flow ratio (all P < 0.05). After adjusting for potential confounding factors, the total CSVD score was still independently correlated with the OA blood velocity (β = − 0.202, P = 0.005). The total CSVD score was not correlated with OA angle (P > 0.05). The presence of cerebral microbleeds and enlarged perivascular spaces was correlated with the OA diameter (both P < 0.01), while the lacunar infarcts and white matter hyperintensities were correlated with the OA blood velocity (both P < 0.001). Conclusions The decrease of the blood velocity in the OA was associated with the increase in the total CSVD score. The changes of the OA diameter and velocity were associated with the presence of various CSVD signs. The findings suggest that more studies are needed in the future to evaluate CSVD by observing the morphologies and hemodynamics of OA.

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Comparison of Ophthalmic Artery Morphological Characteristics and Retinal Vessel Diameter for Identifying Ocular Ischemic Syndrome

Cheng,

Zhao,

Huang

et al. 2023

Invest. Ophthalmol. Vis. Sci.

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Purpose To investigate the morphological characteristics of the ophthalmic artery (OA) and retinal vessels in ocular ischemic syndrome (OIS) and to compare their ability to identify OIS. Methods This cross-sectional observational study included 21 patients with unilateral OIS and 17 controls matched for age, sex, degree of internal carotid artery (ICA) stenosis, and cerebral collateral patency. This study used a three-dimensional reconstruction based on computed tomographic angiography to measure the morphological characteristics of the OA and the ICA. Quantitative measurements of retinal vessel diameter were performed using the Integrative Vessel Analysis software. Receiver operating characteristic (ROC) curve analysis was performed to assess the ability of the OA diameter and the central retinal artery equivalent (CRAE) to identify OIS. Results The diameter of the OA (odds ratio = 0.001; P = 0.001) and the CRAE (odds ratio = 0.951; P = 0.028) were significantly associated with the presence of OIS after adjusting for age, sex, and the degree of the ICA stenosis. The areas under the curve for the OA diameter and the CRAE were, respectively, 0.871 ( P < 0.001) and 0.744 ( P = 0.017) according to the ROC curves analysis. Conclusions The OA diameter measurement identified OIS better than CRAE measurement. The OA may reflect the changes in ocular blood supply in patients with OIS earlier than retinal vessels. The OA of eyes with OIS may undergo arterial wall remodeling, leading to a decrease in OA diameter and further reduction in blood flow.

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Ophthalmic Artery Morphological and Hemodynamic Features in Acute Coronary Syndrome

Cited by 8 publications

References 35 publications

Ophthalmic artery changes in type 2 diabetes with and without acute coronary syndrome

Ophthalmic artery changes in type 2 diabetes with and without acute coronary syndrome

Impact of total cerebral small vessel disease score on ophthalmic artery morphologies and hemodynamics

Comparison of Ophthalmic Artery Morphological Characteristics and Retinal Vessel Diameter for Identifying Ocular Ischemic Syndrome

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