Ophthalmic Artery Doppler Waveform Changes Associated with Increased Damage in Glaucoma Patients

Pinto, Luís Abegão; Vandewalle, Evelien; Clerck, Eline De; Marques-Neves, Carlos; Stalmans, Ingeborg

doi:10.1167/iovs.11-9388

Cited by 30 publications

(29 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In that sense, the pairing between the groups was effective, with both demographic and ocular characteristics matching our previous publications in this field (Abegão Pinto et al. ; Vandewalle et al. ).…”

Section: Discussionsupporting

confidence: 80%

See 1 more Smart Citation

Ocular blood flow in glaucoma – the Leuven Eye Study

Pinto

Willekens

Keer

et al. 2016

Acta Ophthalmologica

Self Cite

107

View full text Add to dashboard Cite

ABSTRACT.Purpose: Elevated intra-ocular pressure (IOP) has been identified as a major risk factor for glaucoma. Additionally, extensive literature depicts a vascular dysfunction to exist in these patients. However, a large ocular blood floworiented trial to integrate these findings in the clinical setting is lacking. This study would likely help to identify which of these vascular data can be used as a clinical tool for screening and disease stratification. Method: Prospective, cross-sectional, case-control hospital-based study.Patients with primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG), ocular hypertension (OHT), glaucoma suspects and healthy volunteers were recruited. In addition to a comprehensive ophthalmological examination, a vascular-oriented questionnaire was completed and ocular blood flow assessment (colour Doppler imaging of retrobulbar vessels, retinal oximetry, dynamic contour tonometry, optical coherent tomography enhanced-depth imaging of the choroid) were performed. Statistical analysis was based on multiple imputation to account for missingness. Results: A total of 614 subjects (291 males) were recruited between March and December 2013 (POAG: 214, NTG: 192; OHT: 27; glaucoma suspect: 41; healthy controls: 140). Glaucoma groups (NTG and POAG) were age and gender matched with the control group (p > 0.05). Glaucoma groups were paired in terms of functional and structural parameters (p > 0.08). Mean ocular perfusion pressure was higher in the glaucoma groups than in controls (p < 0.001). Glaucoma groups had lower retrobulbar velocities, higher retinal venous saturation and choroidal thickness asymmetries when compared to the healthy group, in line with the current literature. Conclusions: The Leuven Eye Study stands as one of the largest clinical trials on ocular blood flow in glaucoma. The creation of this vast database may help integrate the vascular aspects of glaucoma into the clinical practice of glaucoma.

show abstract

Section: Discussionsupporting

confidence: 80%

“…A more complete Doppler waveform analysis, as detailed elsewhere (Abegão Pinto et al. ) was performed offline. Choroidal thickness data (CT) were obtained through a high definition (HD) 5 Line Raster using the enhanced‐depth imaging (EDI) mode included in the Cirrus 4000 HD OCT model (Carl Zeiss, Dublin, CA) using the 6.5 software.…”

Section: Methodsmentioning

confidence: 99%

Ocular blood flow in glaucoma – the Leuven Eye Study

Pinto

Willekens

Keer

et al. 2016

Acta Ophthalmologica

Self Cite

107

View full text Add to dashboard Cite

show abstract

“…Our findings indicate that Sm/Dm may be a more sensitive variable to detect intracranial hypertension compared with RI and PI. A previous study evaluating Doppler waveforms of the ophthalmic artery showed that Sm/Dm can be more sensitive for the detection of glaucoma in human patients than RI . The higher sensitivity of Sm/Dm in our study might have been because of the difference in calculation methods of each TCD vascular resistance variable.…”

Section: Discussionmentioning

confidence: 62%

Transcranial Doppler Ultrasound Examination in Dogs with Suspected Intracranial Hypertension Caused by Neurologic Diseases

Sasaoka

Nakamura

Osuga

et al. 2017

Veterinary Internal Medicne

View full text Add to dashboard Cite

BackgroundTranscranial Doppler ultrasound examination (TCD) is a rapid, noninvasive technique used to evaluate cerebral blood flow and is useful for the detection of intracranial hypertension in humans. However, the clinical usefulness of TCD in diagnosing intracranial hypertension has not been demonstrated for intracranial diseases in dogs.ObjectivesTo determine the association between the TCD variables and intracranial hypertension in dogs with intracranial diseases.AnimalsFifty client‐owned dogs with neurologic signs.MethodsCross‐sectional study. All dogs underwent TCD of the basilar artery under isoflurane anesthesia after magnetic resonance imaging (MRI). Dogs were classified into 3 groups based on MRI findings: no structural diseases (group I), structural disease without MRI evidence of intracranial hypertension (group II), and structural disease with MRI evidence of intracranial hypertension (group III). The TCD vascular resistance variables (resistive index [RI], pulsatility index [PI], and the ratio of systolic to diastolic mean velocity [Sm/Dm]) were measured.ResultsFifteen, 22, and 13 dogs were classified into groups I, II, and III, respectively. Dogs in group III had significantly higher Sm/Dm (median, 1.78; range, 1.44–2.58) than those in group I (median, 1.63; range, 1.43–1.75) and group II (median, 1.62; range, 1.27–2.10). No significant differences in RI and PI were identified among groups.Conclusions and Clinical ImportanceOur findings suggest that increased Sm/Dm is associated with MRI findings of suspected intracranial hypertension in dogs with intracranial diseases and that TCD could be a useful tool to help to diagnose intracranial hypertension.

show abstract

“…): acceleration (Acc), systolic and diastolic mean velocities ( S m and D m ) and their ratio ( S m / D m ), peak systolic and end‐diastolic velocity (PSV and EDV), resistance index (RI) and mean flow velocities (MFV) as described elsewhere (Abegão Pinto et al. ). The following variables were analysed in the central retinal vein: maximal and minimal velocity ( V max and V min , respectively) and RI (Fig.…”

Section: Methodsmentioning

confidence: 99%

“…Recently, it has been suggested that more complete Doppler waveform analysis of the retrobulbar vessels (including early systolic acceleration, mean systolic and diastolic flow velocities and the ratio between those two) might provide valuable information concerning the arteries' elasticity and compliance and their ability to buffer and accommodate a pulsatile blood flow (Abegão Pinto et al. ).…”

Section: Introductionmentioning

confidence: 99%

Ocular pulse amplitude and Doppler waveform analysis in glaucoma patients

Pinto

Vandewalle

Willekens

et al. 2014

Acta Ophthalmologica

Self Cite

View full text Add to dashboard Cite

ABSTRACT.Purpose: To determine the correlation between ocular blood flow velocities and ocular pulse amplitude (OPA) in glaucoma patients using colour Doppler imaging (CDI) waveform analysis. Method: A prospective, observer-masked, case-control study was performed. OPA and blood flow variables from central retinal artery and vein (CRA, CRV), nasal and temporal short posterior ciliary arteries (NPCA, TPCA) and ophthalmic artery (OA) were obtained through dynamic contour tonometry and CDI, respectively. Univariate and multiple regression analyses were performed to explore the correlations between OPA and retrobulbar CDI waveform and systemic cardiovascular parameters (blood pressure, blood pressure amplitude, mean ocular perfusion pressure and peripheral pulse). Results: One hundred and ninety-two patients were included [healthy controls: 55; primary open-angle glaucoma (POAG): 74; normal-tension glaucoma (NTG): 63]. OPA was statistically different between groups (Healthy: 3.17 AE 1.2 mmHg; NTG: 2.58 AE 1.2 mmHg; POAG: 2.60 AE 1.1 mmHg; p < 0.01), but not between the glaucoma groups (p = 0.60). Multiple regression models to explain OPA variance were made for each cohort (healthy: p < 0.001, r = 0.605; NTG: p = 0.003, r = 0.372; POAG: p < 0.001, r = 0.412). OPA was independently associated with retrobulbar CDI parameters in the healthy subjects and POAG patients (healthy CRV resistance index: b = 3.37, CI: 0.16-6.59; healthy NPCA mean systolic/diastolic velocity ratio: b = 1.34, CI: 0.52-2.15; POAG TPCA mean systolic velocity: b = 0.14, CI 0.05-0.23). OPA in the NTG group was associated with diastolic blood pressure and pulse rate (b = À0.04, CI: À0.06 to À0.01; b = À0.04, CI: À0.06 to À0.001, respectively). Conclusions: Vascular-related models provide a better explanation to OPA variance in healthy individuals than in glaucoma patients. The variables that influence OPA seem to be different in healthy, POAG and NTG patients.

show abstract

Ophthalmic Artery Doppler Waveform Changes Associated with Increased Damage in Glaucoma Patients

Abstract: The pattern of blood flow velocities in the OA throughout the cardiac cycle seems to be altered in glaucoma patients. Further studies on how systemic blood pressure affects waveform variables in glaucoma patients may provide a better understanding of an underlying vascular dysfunction.

Cited by 30 publications

References 32 publications

Ocular blood flow in glaucoma – the Leuven Eye Study

Ocular blood flow in glaucoma – the Leuven Eye Study

Transcranial Doppler Ultrasound Examination in Dogs with Suspected Intracranial Hypertension Caused by Neurologic Diseases

Ocular pulse amplitude and Doppler waveform analysis in glaucoma patients

Contact Info

Product

Resources

About