Ophthalmic and Neuro-ophthalmic Manifestations of Coronavirus Disease 2019 (COVID-19)

Ortiz-Seller, Amparo; Martínez-Costa, Lucía; Hernández-Pons, Antonio; Pascual, Elia Valls; Alemany, Alicia Solves; Albert-Fort, Mara

doi:10.1080/09273948.2020.1817497

Cited by 83 publications

(77 citation statements)

References 32 publications

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“…Furthermore, there is some dispute as to whether SARS-CoV-2 affects the retina and choroid, taking into consideration the fact that ACE2, which is a receptor for the virus, has been identified in these structures [ 15 , 16 , 17 ]. After the outbreak of the pandemic, retinal and vascular pathologies in patients with coronavirus disease 2019 were rapidly reported [ 18 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…In previously published studies, connections between rare ocular conditions such as inflammatory chorioretinopathy, serpiginous choroiditis, central retinal artery occlusion, optic neuritis, and impending central retinal vein occlusion have also been described [ 15 , 16 , 21 , 22 , 23 ]. All of these disorders have been reported as single cases and have not been observed on a larger scale.…”

Section: Discussionmentioning

confidence: 99%

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Retinal OCT Findings in Patients after COVID Infection

Szkodny

Wylęgała

Sujka-Franczak³

et al. 2021

JCM

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Purpose: The aim of this study was to assess and compare the optic nerve, retina, and retinal vessel parameters in recovered COVID-19 patients and healthy patients by using optical coherence tomography angiography (OCT-a). Methods: In all, 156 eyes of post-COVID-19 patients and 98 eyes of subjects from a control group were enrolled in our study. BCVA, intra ocular pressure (IOP) measurement, fundus examination, and OCT images, including macular cube, OCT-RNFL, and angio-OCT 6 × 6 mm examinations, were performed for both groups. The measurements were acquired using Swept Source OCT DRI OCT Triton. In the post-COVID-19 group, 762 OCT protocols were obtained. For statistical analysis, parameters from only one eye from each subject were taken. Results: In the measured parameters, no significant differences were observed, i.e., central macular thickness (p = 0.249); RNFL (p = 0.104); FAZ (p = 0.63); and vessel density of superficial retinal vascular plexus in central (p = 0.799), superior (p = 0.767), inferior (p = 0.526), nasal (p = 0.402), and temporal (p = 0.582) quadrants. Furthermore, a slit-lamp examination did not reveal any COVID-19-related abnormalities. Conclusion: OCT examination did not detect any significant changes in morphology or morphometry of the optic nerve, retina, or the retina vessels due to COVID-19.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Retinal OCT Findings in Patients after COVID Infection

Szkodny

Wylęgała

Sujka-Franczak³

et al. 2021

JCM

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“…Unilateral panuveitis in a 60 years old woman with definitive diagnosis of COVID-19, drew the attention of Benito and colleagues to the linkage between them [32]. Also, as we reviewed the studies on ophthalmic manifestations of COVID-19, encountered the interesting association with white dot syndromes (WDS) spectra [44].…”

Section: Ocular Inflammation and Uveitismentioning

confidence: 98%

Hypothesis on Pathophysiologic Mechanisms in COVID-19 Rare Ophthalmic Presentations; A Review

Jafari¹,

Bagheri²,

Jafari‬³

2021

Act Sci Oph

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In late 2019, the world encountered the novel coronavirus severe acute respiratory syndrome (COVID-19) pandemic. Ophthalmic findings in COVID-19 patients were mainly ocular surface initially. Over time, different ocular involvements were reported in this pandemic. The aim of this study was to review the variety of possible ocular involvements with underlying pathophysiologic hypotheses in COVID-19. This study demonstrates the variety of suspicious ocular involvements in COVID-19 from ocular irritation to visual loss in three different categories: direct infectious ocular involvement, indirect ophthalmic complications and therapeuticprophylactic options ocular side effects. This review represents a panoramic spectra of COVID-19 ophthalmic symptomatology with possible underlying pathophysiology.

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“…Ortiz-Seller et al [ 73 ] described a case of inflammatory chorioretinopathy with coexisting Adie syndrome occurring in a 51-year-old patient diagnosed with COVID-19 who reported retroocular pain and reading impairment 2 days after the onset of disease symptoms. A fundus examination revealed numerous yellowish, creamy, deep peripheral chorioretinal lesions, and OCT demonstrated bilateral areas of impaired capillary perfusion, inner retinal thinning, and focal disruptions of the outer retinal layers.…”

Section: Retinal Pathologiesmentioning

confidence: 99%

SARS-CoV-2 and the Eyes: A Review of the Literature on Transmission, Detection, and Ocular Manifestations

Szczęśniak

Brydak-Godowska

2021

Med Sci Monit

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During the coronavirus disease 2019 (COVID-19) pandemic, numerous reports of ocular anomalies occurring in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged. The most frequently reported pathology is conjunctivitis, which may be the first or only clinical manifestation of the disease. Involvement of SARS-CoV-2 in development of alterations in other ocular structures was suggested, including the cornea, the retina, and blood vessels. Possible mechanisms include direct activity of the viral agent, as well as systemic inflammatory response with accompanying thromboembolic complications. Genetic material of SARS-CoV-2 was detected in ocular secretions of infected individuals, including asymptomatic patients. Moreover, angiotensin-converting enzyme 2 (ACE2), a receptor protein used by the virus to enter the cell, has been found on the surface of various structures of the eye, which indicates a risk of transmission through ocular tissues. Therefore, it is crucial to use eye protection by medical professionals having contact with potentially infected patients. This paper is a review of the literature regarding ocular manifestations of SARS-CoV-2 infection and a summary of the current state of knowledge about possibility of transmission from an ophthalmology point of view. For data collection, a thorough PubMed search was performed, using the key words: “COVID ocular”, “COVID eye”, “SARS-CoV-2 ocular”, and “SARS-CoV-2 eye”. Conclusions: SARS-CoV-2 infection may manifest itself in various ocular conditions. Eye protection should not be neglected, as recent studies suggest the eye as a potential route of transmission. Further search for adequate safety measures in ophthalmology practice is required.

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Ophthalmic and Neuro-ophthalmic Manifestations of Coronavirus Disease 2019 (COVID-19)

Cited by 83 publications

References 32 publications

Retinal OCT Findings in Patients after COVID Infection

Retinal OCT Findings in Patients after COVID Infection

Hypothesis on Pathophysiologic Mechanisms in COVID-19 Rare Ophthalmic Presentations; A Review

SARS-CoV-2 and the Eyes: A Review of the Literature on Transmission, Detection, and Ocular Manifestations

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