Ophiobolin E and 8-epi-ophiobolin J produced by Drechslera gigantea, a potential mycoherbicide of weedy grasses

Evidente, Antonio; Andolfi, Anna; Cimmino, Alessio; Vurro, Maurizio; Fracchiolla, Mariano; Charudattan, R.; Motta, Andréa

doi:10.1016/j.phytochem.2006.07.016

Cited by 52 publications

(54 citation statements)

References 16 publications

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“…However, culture filtrates of all the Drechslera species significantly declined shoot biomass over the control by 34 to 69% and 69 to 82% when applied in a diluted and original concentration, respectively (Table 1). These findings agree with the results of some earlier studies where culture filtrates of other Drechslera species exhibited herbicidal activity against weeds (Kastanias and Tokousbalides, 2000;Evidente et al, 2005;2006a). Various herbicidal constituents have been identified from different Drechslera species.…”

Section: Laboratory Bioassayssupporting

confidence: 91%

Herbicidal Potential of Drechslera spp. Culture Filtrates Against Parthenium hysterophorus L.

Javaid

Akbar

2011

Chilean J. Agric. Res.

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Section: Laboratory Bioassayssupporting

confidence: 91%

Herbicidal Potential of Drechslera spp. Culture Filtrates Against Parthenium hysterophorus L.

Javaid

Akbar

2011

Chilean J. Agric. Res.

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“…It is known by several common names and used as animal fodder. 110 The different levels of phytotoxicity shown by the two (92 and 91) could be attributed to the different conformation assumed by the octacyclic ring, as a consequence of the different position of the double bond, located between C-7 and C-8 in 92, and between C-6 and C-7 in 90. 101 D. gigantea is a cosmopolitan fungal pathogen found throughout North and South America, Japan, and other regions.…”

Section: Aromatic Compoundsmentioning

confidence: 99%

“…The seeds are edible and used as a grain in Germany and especially Poland, where it is sometimes cultivated. 110 102 weedy grasses.…”

Section: Aromatic Compoundsmentioning

confidence: 99%

Fungal phytotoxins with potential herbicidal activity: chemical and biological characterization

Cimmino¹,

Masi²,

Evidente³

et al. 2015

Nat. Prod. Rep.

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150

149

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Covering: 2007 to 2015 Fungal phytotoxins are secondary metabolites playing an important role in the induction of disease symptoms interfering with host plant physiological processes. Although fungal pathogens represent a heavy constraint for agrarian production and for forest and environmental heritage, they can also represent an ecofriendly alternative to manage weeds. Indeed, the phytotoxins produced by weed pathogenic fungi are an efficient tool to design natural, safe bioherbicides. Their use could avoid that of synthetic pesticides causing resistance in the host plants and the long term impact of residues in agricultural products with a risk to human and animal health. The isolation and structural and biological characterization of phytotoxins produced by pathogenic fungi for weeds, including parasitic plants, are described. Structure activity relationships and mode of action studies for some phytotoxins are also reported to elucidate the herbicide potential of these promising fungal metabolites.

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“…For example, Drechslera gigantea (fungus), a potential mycoherbicide of grass weeds proposed for the biocontrol of crabgrass ( Digitaria sanguinalis ), was found to produce ophiobolin A, 6- epi - and 3-anhydro-6- epi -ophiobolin A, and ophiobolin I in liquid culture [25]. However, the same fungus grown in solid culture produced new ophiobolins E and epi -ophiobolin J together with known ophiobolins B and J [26]. Numerous literature reports have appeared describing the biological activities of activities of ophiobolins [12].…”

Section: Introductionmentioning

confidence: 99%

Sesterterpenoids with Anticancer Activity

Evidente¹,

Kornienko²,

Lefranc³

et al. 2015

CMC

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Terpenes have received a great deal of attention in the scientific literature due to complex, synthetically challenging structures and diverse biological activities associated with this class of natural products. Based on the number of C5 isoprene units they are generated from, terpenes are classified as hemi- (C5), mono- (C10), sesqui- (C15), di- (C20), sester- (C25), tri (C30), and tetraterpenes (C40). Among these, sesterterpenes and their derivatives known as sesterterpenoids, are ubiquitous secondary metabolites in fungi, marine organisms, and plants. Their structural diversity encompasses carbotricyclic ophiobolanes, polycyclic anthracenones, polycyclic furan-2-ones, polycyclic hydroquinones, among many other carbon skeletons. Furthermore, many of them possess promising biological activities including cytotoxicity and the associated potential as anticancer agents. This review discusses the natural sources that produce sesterterpenoids, provides sesterterpenoid names and their chemical structures, biological properties with the focus on anticancer activities and literature references associated with these metabolites. A critical summary of the potential of various sesterterpenoids as anticancer agents concludes the review.

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Ophiobolin E and 8-epi-ophiobolin J produced by Drechslera gigantea, a potential mycoherbicide of weedy grasses

Cited by 52 publications

References 16 publications

Herbicidal Potential of Drechslera spp. Culture Filtrates Against Parthenium hysterophorus L.

Herbicidal Potential of Drechslera spp. Culture Filtrates Against Parthenium hysterophorus L.

Fungal phytotoxins with potential herbicidal activity: chemical and biological characterization

Sesterterpenoids with Anticancer Activity

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