OPG and RANKL polymorphisms are associated with alcohol-induced osteonecrosis of the femoral head in the north area of China population in men

Li, Yizhou; Wang, Yuan; Yong-chang, Guo; Wang, Quanjian; Ouyang, Yongri; Cao, Yong; Jin, Tianbo; Wang, Jianzhong

doi:10.1097/md.0000000000003981

Cited by 26 publications

(15 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The OPG/RANKL/RANK signaling pathway is a very important mechanism that regulates bone metabolism 17 . OPG is a soluble RANKL decoy receptor that binds to three RANKL subtypes and blocks RANKL and RANK binding 18 . Gori et al 19 found that developmental regulation of OPG and RANKL production contributes to the coordinated sequence of osteoclast and osteoblast differentiation during the bone remodeling cycle.…”

Section: Discussionmentioning

confidence: 99%

Analysis of early stage osteonecrosis of the human femoral head and the mechanism of femoral head collapse

Wang¹,

Meng²,

Wang³

et al. 2018

Int. J. Biol. Sci.

View full text Add to dashboard Cite

We explored the mechanism of early stage osteonecrotic femoral head collapse by analyzing and comparing different regions in human osteonecrotic femoral head samples. Eight osteonecrotic femoral heads (ARCO II-III) were obtained from patients undergoing total hip arthroplasty. Bone structure was observed and evaluated by micro-computed tomography (CT) scans and pathology. Osteoblast and osteoclast activities were detected by tartrate-resistant acid phosphatase, alkaline phosphatase, and immunofluorescent staining. Some trabeculae had microfractures in the subchondral bone and necrotic region, which had lower bone mineral density, as well as trabecular thickness and number, but greater osteoclast activity. A sclerotic band had already appeared in certain samples which had greater trabecular thickness and number, bone mineral density, and osteoblast activity. The appearance of the femoral head did not change significantly in the early stage of osteonecrosis of the femoral head. However, osteoblast and osteoclast activities had already changed in different regions of the osteonecrotic femoral head, which may lead to eventual collapse of the femoral head. Therefore, osteonecrosis of the femoral head must be treated during the early stage. In addition, osteoblast activity should be promoted and osteoclast activity inhibited as early as possible to prevent collapse of an osteonecrotic femoral head.

show abstract

Section: Discussionmentioning

confidence: 99%

Analysis of early stage osteonecrosis of the human femoral head and the mechanism of femoral head collapse

Wang¹,

Meng²,

Wang³

et al. 2018

Int. J. Biol. Sci.

View full text Add to dashboard Cite

show abstract

“…According to statistics in China, 30.7% of ONFH cases are caused by alcohol [11]. Thereinto, genetic polymorphisms of some genes played critical roles in the occurrence of alcohol-induced ONFH [12][13][14][15][16][17], such as MMP20, RETN, ApoB, ApoA1, NOS3.…”

Section: Introductionmentioning

confidence: 99%

Correlation analysis between CARMEN variants and alcohol-induced osteonecrosis of the femoral head in the Chinese population

Yong-chang

Cao

Gong

et al. 2020

BMC Musculoskelet Disord

Self Cite

View full text Add to dashboard Cite

Background: Osteonecrosis of the femoral head (ONFH) is a complicated disease associated with trauma, hormone abuse and excessive alcohol consumption. Polymorphisms of long non-coding RNAs have been also linked with the development of ONFH. Our research aimed to explore the relationship between CARMEN (Cardiac Mesoderm Enhancer-Associated Non-Coding RNA) variants and ONFH risk. Methods: Our study used Agena MassARRAY Assay to genotype 6 selected single nucleotide polymorphisms (SNPs) in 731 participants (308 alcohol-induced ONFH patients and 423 controls). We used odds ratios (ORs) and 95% confidence intervals (CIs) to calculate the effect of gene polymorphisms on the occurrence of alcohol-induced ONFH by logistic regression analysis and haplotype analysis. Results: Our overall analysis illustrated that rs13177623 and rs12654195 had an association with a reduced risk of ONFH after adjustment for age and gender. We also found that rs13177623, rs12654195 and rs11168100 were associated with a decreased susceptibility to alcohol-induced ONFH in people ≤45 years. In addition, the necrotic sites stratification analysis showed that rs12654195 was only found to be related to alcohol-induced ONFH risk in the recessive model. In patients with different clinical stages, rs353300 was observed to be associated with a higher incidence of ONFH. Individuals with different genotypes of rs13177623, rs12654195 and rs11168100 had significantly different clinical parameters (cholinesterase, globulin, percentage of neutrophils and the absolute value of lymphocytes). Conclusions: Our data provided new light on the association between CARMEN polymorphisms and alcoholinduced ONFH risk in the Chinese Han population.

show abstract

“…[17,18] On this context, the definition or classification criteria varies widely across previous studies on AA-ONFH. Among 18 English-written studies published from 2015 to 2017 with a sample size of 200 or more, 6 studies used 400 mL/week as the cut-off level of alcohol exposure, [19][20][21][22][23][24] 2 studies did 900 mL/week, [25,26] and one study did 40 g/day for men or 20 g/day for women to defined AA-ONFH. [3] Even a worse problem is that 50% (9/18) did not describe their definition for AA-ONFH.…”

Section: Introductionmentioning

confidence: 99%

Etiologic Classification Criteria of ARCO on Femoral Head Osteonecrosis Part 2: Alcohol-Associated Osteonecrosis

Yoon

Jones

et al. 2019

The Journal of Arthroplasty

View full text Add to dashboard Cite

Objective: Although alcohol is a leading risk factor for osteonecrosis of the femoral head (ONFH) and its prevalence reportedly ranges from 20% to 45%, there are no unified classification criteria for this subpopulation. In 2015, Association Research Circulation Osseous (ARCO) decided to develop classification criteria for alcohol-associated ONFH (AA-ONFH). Methods: In June of 2017, ARCO formed a task force to conduct a Delphi survey. The task force invited twenty-eight experts in osteonecrosis/bone circulation from eight countries. Each round of the Delphi survey included questionnaires, analysis of replies, and feedback reports to the panel. After three rounds of the survey, consensus was reached on the classification criteria. The response rates for the three Delphi rounds were 100% (Round 1), 96% (Round 2), and 100% (Round 3). Results: The consensus on the classification criteria of AA-ONFH included: 1) patients should have a history of alcohol intake > 400 mL/week (320 g/week, any type of alcoholic beverage) of pure ethanol for more than 6 months; 2) ONFH should be diagnosed within 1 year after alcohol intake of this dose; and 3) patients should not have other risk factor(s). Conclusion: ARCO established classification criteria to standardize clinical studies concerning AA-ONFH.

show abstract

OPG and RANKL polymorphisms are associated with alcohol-induced osteonecrosis of the femoral head in the north area of China population in men

Cited by 26 publications

References 30 publications

Analysis of early stage osteonecrosis of the human femoral head and the mechanism of femoral head collapse

Analysis of early stage osteonecrosis of the human femoral head and the mechanism of femoral head collapse

Correlation analysis between CARMEN variants and alcohol-induced osteonecrosis of the femoral head in the Chinese population

Etiologic Classification Criteria of ARCO on Femoral Head Osteonecrosis Part 2: Alcohol-Associated Osteonecrosis

Contact Info

Product

Resources

About