In this article, we obtain two sets of results. The first set of complete results are exclusively for the case of the bi-disc while the second set of results describe in part, which of these carry over to the general case of the poly-disc:A classification of irreducible hermitian holomorphic vector bundles over D 2 , homogeneous with respect to Möb × Möb, is obtained assuming that the associated representations are multiplicity-free. Among these the ones that give rise to an operator in the Cowen-Douglas class of D 2 of rank 1, 2 or 3 is determined. Any hermitian holomorphic vector bundle of rank 2 over D n , homogeneous with respect to the n-fold product of the group Möb is shown to be a tensor product of n − 1 hermitian holomorphic line bundles, each of which is homogeneous with respect to Möb and a hermitian holomorphic vector bundle of rank 2, homogeneous with respect to Möb. The classification of irreducible homogeneous hermitian holomorphic vector bundles over D 2 of rank 3 (as well as the corresponding Cowen-Douglas class of operators) is extended to the case of D n , n > 2. It is shown that there is no irreducible n -tuple of operators in the Cowen-Douglas class B2(D n ) that is homogeneous with respect to Aut(D n ), n > 1. Also, pairs of operators in B3(D 2 ) homogeneous with respect to Aut(D 2 ) are produced, while it is shown that no ntuple of operators in B3(D n ) is homogeneous with respect to Aut(D n ), n > 2.