We study various operator homological properties of the Fourier algebra A(G) of a locally compact group G. Establishing the converse of two results of Ruan and Xu [35], we show that A(G) is relatively operator 1-projective if and only if G is IN, and that A(G) is relatively operator 1-flat if and only if G is inner amenable. We also exhibit the first known class of groups for which A(G) is not relatively operator C-flat for any C ≥ 1. As applications of our techniques, we establish a hereditary property of inner amenability, answer an open question of Lau and Paterson [25], and answer an open question of Anantharaman-Delaroche [1] on the equivalence of inner amenability and Property (W). In the bimodule setting, we show that relative operator 1-biflatness of A(G) is equivalent to the existence of a contractive approximate indicator for the diagonal G ∆ in the Fourier-Stieltjes algebra B(G×G), thereby establishing the converse to a result of Aristov, Runde, and Spronk [3]. We conjecture that relative 1-biflatness of A(G) is equivalent to the existence of a quasi-central bounded approximate identity in L 1 (G), that is, G is QSIN, and verify the conjecture in many special cases. We finish with an application to the operator homology of A cb (G), giving examples of weakly amenable groups for which A cb (G) is not operator amenable.