“…However, some factors appear consistent across studies. These include: rostral sparing [dysmorphic growth patterns with sparing of the head and upper limbs (Burwell et al, 1978;Burwell, 1988)], being short in stature while being heavy/normal weight for age (Goff, 1954;Ralston, 1955;Cameron and Izatt, 1960;Weiner and O'Dell, 1970;Fisher, 1972;Emr et al, 1973;Katz and Siffert, 1977;Burwell et al, 1978;Wynne-Davies and Gormley, 1978;Cannon et al, 1989;Wiig et al, 2006;) (although these factors were not found to be statistically significant in some studies [Girdany and Osman, 1968;Laron et al, 1973;Kealey et al, 2004;Sharma et al, 2005)], and being skeletally immature (Goff, 1954;Caffey, 1968;Girdany and Osman, 1968;Weiner and O'Dell, 1970;Fisher, 1972;Laron et al, 1973;Emr et al, 1973;Harrison et al, 1976;Katz and Siffert, 1977;Thompson et al, 1978;Bohr, 1979;de Guembecker and Duriez, 1981;Edvardsen et al, 1981;Harrison and Burwell, 1981;Kristmundsdottir et al, 1984Kristmundsdottir et al, , 1986Kristmundsdottir et al, , 1987Wijesekera, 1984;Thompson and Salter, 1987;Burwell, 1988;…”