Operative Risks of Domino Liver Transplantation for the Familial Amyloid Polyneuropathy Liver Donor and Recipient: A Double Analysis

Tincani, Giovanni; Hoti, Emir; Andreani, P.; Ricca, Luana; Pittau, Gabriella; Vitale, Virginia; Blandin, F.; Adam, René; Castaing, Denis; Azoulay, Daniel

doi:10.1111/j.1600-6143.2011.03477.x

Cited by 39 publications

(51 citation statements)

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“…The use of the liver explant for domino transplant is well established for familial amyloid polyneuropathy and MSUD . This technique could also be extended in selected cases to include organic acidemias and hypercholesterolemia .…”

Section: Discussionmentioning

confidence: 99%

“…The use of the liver explant for domino transplant is well established for familial amyloid polyneuropathy and MSUD. (3,26) This technique could also be extended in selected cases to include organic acidemias and hypercholesterolemia. (27,28) The recent report of successful auxiliary domino transplant from a child with propionic acidemia to correct Crigler-Najjar syndrome raises the possibility of organ exchanges between those with different metabolic diseases.…”

Section: Original Article | 919mentioning

confidence: 99%

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Evolving Trends in Liver Transplant for Metabolic Liver Disease in the United States

et al. 2019

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Indications for liver transplantation (LT) in metabolic disease are evolving. We reviewed the US experience with primary LT for metabolic disease in the Scientific Registry for Transplant Recipients (October 1987 to June 2017) to determine the following: temporal changes in indications, longterm outcomes, and factors predicting survival. Patients were grouped by the presence of structural liver disease (SLD) and whether the defect was confined to the liver. There were 5996 patients who underwent LT for metabolic disease, 2354 (39.3%) being children. LT for metabolic disease increased in children but not in adults. Children experienced a 6‐fold increase in LT for metabolic disease without SLD. Indications for LT remained stable in adults. Living donor liver transplantation increased between era 1 and era 3 from 5.6% to 7.6% in children and 0% to 4.5% in adults. Patient and graft survival improved with time. The latest 5‐year patient survival rates were 94.5% and 81.5% in children and adults, respectively. Outcomes were worse in adults and in those with extrahepatic disease (P < 0.01), whereas SLD did not affect outcomes. Survival improved with younger age at LT until age <2 years. On multivariate analysis, diagnostic category, inpatient status, age at LT, and transplant era significantly predicted outcomes in all ages with male sex predicting survival in childhood only. Children without structural disease were less likely to die awaiting LT and had improved post‐LT survival compared with children with chronic liver disease. In conclusion, LT for metabolic disease is increasingly used for phenotypic correction in children; extrahepatic manifestations significantly impact survival at all ages; where indicated, transplantation should not be unnecessarily delayed; and the development of new allocation models may be required.

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Section: Discussionmentioning

confidence: 99%

Section: Original Article | 919mentioning

confidence: 99%

Evolving Trends in Liver Transplant for Metabolic Liver Disease in the United States

et al. 2019

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“…The affected liver is usually anatomically and functionally normal and has been reused in domino LT. Over 1000 domino LTs have been performed worldwide using FAP livers. Although immediate operative risks between FAP liver recipients and deceased donor liver recipients are similar, de novo amyloidosis is an increasingly more recognized complication of domino LT. FAP can be transmitted from affected donors to naïve recipients. Patients who receive FAP livers develop sensory neuropathies as early as 7‐8 years after domino LT, as suggested by tissue biopsies .…”

Section: Familial Amyloid Polyneuropathymentioning

confidence: 99%

Genetic, hematological, and immunological disorders transmissible with liver transplantation

Tan¹,

Florman

Schiano

2017

Liver Transpl

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It is well recognized that solid organ transplantation can transmit bacterial infection and chronic viral hepatitis as well as certain cancers. As indications for liver transplantation (LT) have expanded, it has been used to treat and even cure certain genetic cholestatic disorders, urea cycle defects, and coagulation abnormalities; many of these conditions are potentially transmissible with LT as well. It is important for clinicians and transplant patients to be aware of these potentially transmissible conditions as unexplained post-LT complications can sometimes be related to donor transmission of disease and thus should prompt a thorough exploration of the donor allograft history. Herein, we will review the reported genetic, metabolic, hematologic, and immunological disorders that are transmissible with LT and describe clinical scenarios in which these cases have occurred, such as in inadvertent or recognized transplantation of a diseased organ, domino transplantation, and with living related liver donation. Liver Transplantation 23 663-678 2017 AASLD.

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“…In domino donation, modifications of the surgical technique (greater care for the liver explant, possible longer time of surgery and anesthesia, the level of vessel transection, and any need of hepatic venoplasty) and a modification of the preoperative management that is required to obtain a transplantable liver graft (some programs use anticoagulation in the MSUD domino donor) should not expose the MSUD patient to additional risks. Although there are not yet data comparing LT outcomes in MSUD domino donors versus nondonors, the European data showed no differences in morbidity and survival rates in the FAP patients …”

mentioning

confidence: 95%

“…Although there are not yet data comparing LT outcomes in MSUD domino donors versus nondonors, the European data showed no differences in morbidity and survival rates in the FAP patients. (4) In this issue of Liver Transplantation, Herden et al (5) describe the outcomes of 15 LTs in MSUD patients (12 children and 3 adults) from whom 14 grafts were used for domino LT in the Eurotransplant area. After 23 months of follow-up, the patient survival rates were 100% for MSUD recipients (all on a free diet) and 93% for domino LT recipients (1 MSUD liver recipient died from tumor recurrence).…”

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confidence: 99%

Maple Syrup Urine Disease and Domino Liver Transplantation: When and How?

2019

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Operative Risks of Domino Liver Transplantation for the Familial Amyloid Polyneuropathy Liver Donor and Recipient: A Double Analysis

Abstract: Although domino liver transplantation (LT) is an

Cited by 39 publications

References 50 publications

Evolving Trends in Liver Transplant for Metabolic Liver Disease in the United States

Evolving Trends in Liver Transplant for Metabolic Liver Disease in the United States

Genetic, hematological, and immunological disorders transmissible with liver transplantation

Maple Syrup Urine Disease and Domino Liver Transplantation: When and How?

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