Operationale Klassifikation der Anfallsformen durch die Internationale Liga gegen Epilepsie: Positionspapier der ILAE-Klassifikations- und Terminologiekommission

Fisher, Robert S.; Cross, J. Helen; French, Jacqueline; Higurashi, Norimichi; Hirsch, Édouard; Jansen, Floor E.; Lagae, Lieven; Moshé, Solomon L.; Peltola, Jukka; Perez, Eliane Roulet; Scheffer, Ingrid E.; Zuberi, Sameer M.

doi:10.1007/s10309-018-0216-8

Cited by 22 publications

(12 citation statements)

References 43 publications

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“…In our series the most common semiology type was CSE, as already observed [3], but focal onset prevailed on generalised (50.8% vs 32.3%). The high frequency of fCSE is in disagreement with previously reported [26] and could be related to the high percentage of focal epilepsy in our sample associated with the use of ILAE classification, which focused on semiology onset [15,20,27].…”

Section: Status Epilepticuscontrasting

confidence: 99%

“…The Salzburg Consensus Criteria were used to perform diagnosis of NCSE [13,14]. Concerning SE semeiology, we distinguished focal convulsive (fCSE), generalised convulsive (gCSE) and non-convulsive status epilepticus (NCSE) focusing on clinical onset following ILAE criteria [15]. Ictal-EEG recording and clinical description in clinical notes consented semeiology characterization.…”

Section: Status Epilepticusmentioning

confidence: 99%

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Clinical characterization of status epilepticus in childhood: a retrospective study in 124 patients

Chiarello

Duranti

Lividini

et al. 2020

Seizure

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The aim of this study is to describe demographic data, semiology and etiology in a pediatric population with status epilepticus (SE) and refractory SE (RSE). Method: We retrospectively reviewed patients with the following inclusion criteria: i) age between two months and eighteen years; ii) SE diagnosis; iii) admission from January 2001 to December 2016; iv) available clinical data. Results: We enrolled 124 patients. Mean and median age was 4.6 ± 4.2 years and 3.3 [1.2-7.5] years respectively.SE had a "de novo" onset in 66.9%. Focal convulsive-SE was the most common semiology (50.8%) whilst generalised (32.3%) and nonconvulsive-SE (NCSE) (16.9%) were less represented. Some etiologies showed a different age distribution: febrile in youngest age (p = 0.002, phi 0.3) and idiopathic-cryptogenic in older children (p = 0.016, phi 0.2).A statistical significance correlation was detected between semiology and etiology (p < 0.001, Cramer's V 0.4), chemotherapy and NCSE (n = 6/21 vs 3/103, p < 0.001) as well as PRES and NCSE (n = 7/21 vs 5/103, p < 0.001).Only 17.7% had a RSE. No correlation was found in demographic and clinical data, but NCSE, acute and idiopathic-cryptogenic etiologies were more frequently associated to RSE. Encephalitis was the most common diagnosis in acute etiologies whereas unknown epilepsy in idiopathic-cryptogenic group. Conclusion: Most of our findings were previously described however we found a significant role of non-antiepileptic treatments (chemotherapy-dialysis) and comorbidity (PRES) determining acute etiology and NCSE. Acute (mostly encephalitis), idiopathic-cryptogenic (mainly unknown-epilepsy) and NCSE were frequently detected in RSE. In the above mentioned conditions a high level of suspicion was recommended.

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Section: Status Epilepticuscontrasting

confidence: 99%

Section: Status Epilepticusmentioning

confidence: 99%

Clinical characterization of status epilepticus in childhood: a retrospective study in 124 patients

Chiarello

Duranti

Lividini

et al. 2020

Seizure

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“…The classification of seizure types and epilepsies was performed based on the latest definitions proposed by the International League against Epilepsy (ILAE) [26,28]. A standardized questionnaire was used to gather information concerning etiology, concomitant diseases, frequency of seizures, anticonvulsant treatment, and, if applicable, its discontinuation during the video-EEG monitoring.…”

Section: Methodsmentioning

confidence: 99%

Efficacy, Tolerability, and Safety of Concentrated Intranasal Midazolam Spray as Emergency Medication in Epilepsy Patients During Video-EEG Monitoring

et al. 2020

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Background An efficient, well tolerated, and safe emergency treatment with a rapid onset of action is needed to prevent seizure clusters and to terminate prolonged seizures and status epilepticus. Objectives This study aimed to examine the efficacy, tolerability, and safety of intranasal midazolam (in-MDZ) spray in clinical practice. Methods In this retrospective, multicenter observational study, we evaluated all patients with peri-ictal application of in-MDZ during video-EEG monitoring at the epilepsy centers in Frankfurt and Marburg between 2014 and 2017. For every patient, we analyzed the recurrence of any seizure or generalized tonic-clonic seizures after index seizures with and without in-MDZ administration. Treatment-emergent adverse events (TEAEs) were also evaluated. Results In-MDZ was used in 243 patients with epilepsy (mean age 35.5 years; range 5-76 years; 46.5% female) for treatment of 459 seizures. A median dose of in-MDZ 5 mg (i.e., two puffs; range 2.5-15 mg) was administered within a median time from EEG seizure onset until in-MDZ application of 1.18 min [interquartile range (IQR) 1.27], while median time from clinical seizure onset until in-MDZ administration was 1.08 min (IQR 1.19). In-MDZ was given within 1 min after EEG seizure onset in 171 seizures. An intraindividual comparison of seizures with and without application of in-MDZ was feasible in 171 patients, demonstrating that in-MDZ reduced the occurrence of any (Cox proportional-hazard model p < 0.001) and generalized tonic-clonic seizure (Cox proportional-hazard model p = 0.0167) over a period of 24 h. The seizure-free timespan was doubled from a median of 5.0 h in controls to a median of 10.67 h after in-MDZ administration. We additionally clustered in-MDZ administrations for the 119 patients who received in-MDZ more than once, comparing them with the index cases without in-MDZ. Even when considering subsequent seizures with in-MDZ administration, a patient receiving in-MDZ is still half as likely to incur another seizure in the upcoming 24 h as compared with when the same patient does not receive in-MDZ (hazard ratio 0.50; 95% CI 0.42-0.60; p < 0.01). In-MDZ was well tolerated without major adverse events. The most common side effects were irritation of the nasal mucosa [37 cases (8.1%)], prolonged sedation [26 cases (5.7%)], and nausea and vomiting [12 cases (2.6%)]. A decline in oxygen saturation was measured after 78 seizures (17%). Conclusion We conclude that in-MDZ is a safe and efficient treatment option to prevent short-term recurrence of seizures. In-MDZ can be administered very quickly by trained staff within 1-2 min after seizure onset. No major cardiocirculatory or respiratory adverse events were observed.

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“…For baseline seizure frequency, focal impaired awareness seizures (according to ILAE classification from 1981: complex partial seizures) and focal to bilateral tonic-clonic seizures (according to ILAE classification from 1981: secondarily generalized seizures) from the last 3 months prior to surgery were averaged. The authors consider the term "aura" as important in the context of epilepsy surgery, therefore they will use "aura" in this manuscript, even though the current classification [12][13][14][15] would classify this seizure-type as "focal aware seizure. " Electroclinical, neuropsychological, psychiatric, and social outcome parameters are not addressed in this study.…”

Section: Schlüsselwörter Epilepsie • Langzeitverlauf • Anfalls-outcommentioning

confidence: 99%

Factors predicting 10-year seizure freedom after temporal lobe resection

Schmitt

Meencke

2020

Z. Epileptol.

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Operationale Klassifikation der Anfallsformen durch die Internationale Liga gegen Epilepsie: Positionspapier der ILAE-Klassifikations- und Terminologiekommission

Cited by 22 publications

References 43 publications

Clinical characterization of status epilepticus in childhood: a retrospective study in 124 patients

Clinical characterization of status epilepticus in childhood: a retrospective study in 124 patients

Efficacy, Tolerability, and Safety of Concentrated Intranasal Midazolam Spray as Emergency Medication in Epilepsy Patients During Video-EEG Monitoring

Factors predicting 10-year seizure freedom after temporal lobe resection

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