Operational strategy of reconfigurable membrane process for bio-based amino acid production

Operational Strategy of Reconfigurable Multi-Effect Evaporation Processes for Bio-Based Amino Acid Production

“…Uncertainties of bioprocesses exhibit considerably greater variability compared to chemical processes. , In our previous study on reconfigurable membrane processes, an algorithm that finds an optimized configuration for these variabilities was reported . In reconfigurable evaporation processes, various conditions such as concentration, feed flow rate, and temperature can change.…”

“…28−31 Previous studies have shown that reconfigurable membrane systems in amino acid processes provide economic benefits, especially with changes in product type or process disturbances. 13 This study focuses on improving economic value in the evaporation process in amino acid production through reconfigurable evaporation processes. Amino acid production involves process liquids with low concentrations (20−200 g L −1 ) of amino acids in water, with water being the major impurity.…”

“…69,70 In our previous study on reconfigurable membrane processes, an algorithm that finds an optimized configuration for these variabilities was reported. 13 In reconfigurable evaporation processes, various conditions such as concentration, feed flow rate, and temperature can change. Although the optimization algorithm for these impacts was not investigated in this study, it will be an important topic for future research.…”

“…Nevertheless, successful applications of RMS in commercial microbial bioprocesses for animal feed grade amino acids were reported . The application of RMS in animal feed grade amino acids can be effective because of various factors: (1) the market demand is influenced by fluctuations in the prices of carbon , and nitrogen sources, the raw materials for amino acids and proteins, , and competitors of amino acids; (2) technical advancements being made in biotechnology over time , requires modification of the manufacturing processes or operating conditions; (3) unpredictable changes in socio-environmental factors, such as international conflicts, , climate change, and natural disasters, can change market demands; (4) the need for eco-friendly product reducing CO 2 emissions have potential impact on the amino acid market. − …”

“…This modularity allows for RMS application through simple piping changes without complex equipment alternations. The simulated moving bed process is a well-known example of a reconfigurable system, in which multiple columns are interchanged facilitating counter flow patterns of solid and liquid phases. − Previous studies have shown that reconfigurable membrane systems in amino acid processes provide economic benefits, especially with changes in product type or process disturbances . This study focuses on improving economic value in the evaporation process in amino acid production through reconfigurable evaporation processes.…”