Operation, hormone therapy and recovery of the patients with severe forms of adenomyosis

Abstract

Endometriosis is among the prevalent gynecological diseases and diagnosed in 10% of women of reproductive age. Endometriosis/adenomyosis is becoming increasingly a health-social problem, which is associated with severe clinical manifestations and recurrent disease which has a negative effect on quality of life, women ability to work and her reproductive function. This article presents modern approaches of drug therapy to treat severe forms of adenomyosis. We have reviewed recent major studies in the field of surgical treatment of this disease, analyzed the main stages of disease progress and the results of our surgeries. Here, we are presenting our own results of long-term post-operative hormonal therapy and complex medical treatment.

Shared Pathogenic and Therapeutic Characteristics of Endometriosis, Adenomyosis, and Endometrial Cancer: A Comprehensive Literature Review

“…Their mechanism of action involves inhibiting ovulation, inducing decidualization, and causing atrophy. Common side effects include bleeding, breast pain, and headaches [ 4 , 10 , 33 , 35 , 36 , 37 ]. Estroprogestins are not recommended for treating endometrial cancers [ 38 ].…”

“…Common side effects include breast tenderness, weight gain, fluid retention, bleeding, acne, headaches, mood swings, and elevated liver enzyme levels. Progestins commonly used for treating endometriosis and adenomyosis include etonogestrel-releasing implants, levonorgestrel-releasing IUDs, and Dienogest [ 4 , 8 , 10 , 11 , 33 , 35 , 36 , 37 , 39 , 40 ].…”

“…Research has demonstrated a significant reduction in pain symptoms and an improvement in quality of life for individuals with endometriosis and adenomyosis when using GnRH analogs. However, a Cochrane review found no significant difference in efficacy between GnRH analogs and Danazol [ 2 , 4 , 10 , 11 , 33 , 35 , 36 , 37 , 40 , 43 ]. In the context of cancer treatment, these analogs inhibit proliferation and are involved in apoptosis [ 44 ].…”

Heterogeneity of clinical symptoms and therapeutic strategies for different subtypes of adenomyosis: An initial single‐center study in China

“…However, we have found that different patients have different responses to drug therapy in clinical practice. Previous studies have found that only half of patients can benefit from progesterone therapy 15–19 . Adenomyosis may lead to a high proportion of infertility.…”

“…Previous studies have found that only half of patients can benefit from progesterone therapy. [15][16][17][18][19] Adenomyosis may lead to a high proportion of infertility. With the opening of China's family planning policy, the increasing female population has fertility requirements.…”