Operant Responding for Dietary Protein in the Golden Hamster (Mesocricetus auratus)

DiBattista, David

doi:10.1016/s0031-9384(99)00043-8

Cited by 12 publications

(7 citation statements)

References 13 publications

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“…As regards FR5, it has been proposed as a moderate-effort schedule measuring both intake and motivation (Vendruscolo et al, 2010), therefore the consistency found here between FR5 and PR3 is in support of this idea. Our results are also in line with previous findings of increased lever presses for protein-rich pellets during FR5 in golden hamsters fed a protein-free diet, relative to nutritionally complete-fed hamsters (DiBattista, 1999).…”

Section: Discussionsupporting

confidence: 93%

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Restriction of dietary protein in rats increases progressive-ratio motivation for protein

Chiacchierini

Naneix

Apergis-Schoute

et al. 2022

Preprint

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Low-protein diets can impact food intake and appetite, but it is not known if motivation for food is changed. In the present study, we used an operant behavioral task, the progressive ratio test, to assess whether motivation for different foods was affected when rats were maintained on a protein-restricted diet (PR, 5% protein diet) compared to non-restricted control rats (NR, 18% protein). Rats were tested either with nutritionally-balanced pellets (18.7% protein, Experiment 1) or protein-rich pellets (35% protein, Experiment 2) as reinforcers. Protein restriction increased breakpoint for protein-rich pellets, relative to non-restricted rats, whereas no difference in breakpoint for nutritionally-balanced pellets was observed between groups. When given free access to either nutritionally-balanced pellets or protein-rich pellets, PR and NR rats did not differ in their intake. We also tested whether a previous history of protein restriction might affect present motivation for different types of food, by assessing breakpoint of previously PR animals that were subsequently put on standard maintenance chow (protein-repleted rats, PRep, Experiment 2). PRep rats did not show increased breakpoint relative to their initial encounter with protein-rich pellets while they were protein-restricted. This study demonstrates that restriction of dietary protein induces a selective increased motivation for protein-rich food, a behavior that rapidly disappears once rats are not in need of protein.

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Section: Discussionsupporting

confidence: 93%

“…Our results are also in line with previous findings of increased lever presses for protein-rich pellets during FR5 in golden hamsters fed a protein-free diet, relative to nutritionally completefed hamsters (DiBattista, 1999).…”

Section: Discussionsupporting

confidence: 93%

Restriction of dietary protein in rats increases progressive-ratio motivation for protein

Chiacchierini

Naneix

Apergis-Schoute

et al. 2022

Preprint

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“…Therefore, to ensure that the animals were free of helminth infection, they were treated with one dose 5 mg/kg Ivomec (Ivomec Gold 1% - Merial saúde animal Ltda, SP, Brazil) via gavage 30 days prior to A. ceylanicum infection. All animals were fed ad libitum with manipulated diets as described in Table 1 [26], for 4 weeks before infection and throughout the experimental period. The hamsters' water and food consumption and weight were measured weekly.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of Biochemical, Hematological and Parasitological Parameters of Protein-Deficient Hamsters Infected with Ancylostoma ceylanicum

et al. 2014

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BackgroundHookworms infect millions of people worldwide and can cause severe clinical symptoms in their hosts. Prospective cohort studies in Brazil show high rates of hookworm reinfection in malnourished children compared to well-nourished children, despite previous treatment. Additionally, soil-transmitted helminth (STH) infections can worsen the nutritional status of affected populations. Therefore, this study aims to clarify the effects of host malnutrition during Ancylostoma ceylanicum infection and how this infection affects host physiological parameters using a hamster model.Methodology/Principal FindingsHamsters were divided into four experimental groups: normal diet or low-protein diet (also referred to as “malnourished”) and A. ceylanicum infection or no infection. More severe pathogenesis was observed in the infected malnourished group, as demonstrated by significant decreases in the hemoglobin concentration, erythrocyte number and packed-cell volume compared to the non-infected malnourished group. Greater numbers of adult parasites and eggs were observed in the malnourished group compared to the control group; however, the oviposition rate was lower in the malnourished group. In general, greater values of total lipids were observed in malnourished animals compared to control animals, including lipids excreted in the stool.ConclusionsIn this work, we have demonstrated that animals fed an isocaloric low-protein diet presented more severe pathogenesis when infected with A. ceylanicum. The increased lipid concentration in the liver and blood is related to the conversion of the excess carbohydrate into fatty acids that increase the concentration of triglycerides in general. Triglycerides were excreted in the feces, indicating that infection associated with malnutrition caused a greater loss of these molecules for this group of animals and confirming the hypothesis that both nutrition and infection are responsible for the malabsorption syndrome. Taken together, the results found in this work confirm the hypothesis that the nutritional condition of the host greatly influences the course of the infection.

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“…Research on how animals respond to protein restriction is of interest because protein intake is critical for survival. Further, prior research has demonstrated that dietary protein restriction in rodents decreases body weight and increases food consumption, energy expenditure, and preference for protein food sources over carbohydrate food sources (Chaumontet et al, 2018; Deutsch et al, 1989; DiBattista, 1999; Dibattista & Holder, 1998; Heinrichs et al, 1990; Morrison & Laeger, 2015; Morrison et al, 2012; Murphy et al, 2018; Piquard et al, 1978; White et al, 2000b). Finally, dietary protein restriction improves metabolism and longevity in mice (Solon‐Biet et al, 2014), consistent with reported associations between low protein intake and reductions in cancer and mortality in humans (Levine et al, 2014), suggesting the possible utility of protein restriction in dealing with metabolic dysfunction and obesity in humans.…”

mentioning

confidence: 99%

Dynamic effects of dietary protein restriction on body weights, food consumption, and protein preference in C57BL/6J and Fgf21‐KO mice

Torres

Khan

Fernandez-Kim

et al. 2022

J Exper Analysis Behavior

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Single‐case experimental designs (SCEDs) are rarely used in behavioral neuroscience despite their potential benefits. The current study used a SCED to evaluate the effects of dietary protein restriction in C57BL/6J and Fgf21‐knockout (KO) mice on body weight, food consumption, and protein preference and changes in those outcome measures were quantified using multilevel linear models. In C57BL/6J mice, rate of weight gain was lower and food consumption and protein preference higher during periods of low (4% kcal) protein diet feeding compared to periods of normal (18% kcal) protein diet feeding. In Fgf21‐KO mice, who do not produce the liver‐derived hormone FGF21, rate of weight gain and protein preference were not substantially affected by diet although food consumption was slightly higher during periods of low protein diet than periods of normal protein diet. These results demonstrate that protein restriction dynamically regulates physiological and behavioral responses at the individual mouse level and that FGF21 is necessary for those responses. Further, the current results demonstrate how a SCED can be used in behavioral neuroscience research, which entails both scientific and practical benefits.

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Operant Responding for Dietary Protein in the Golden Hamster (Mesocricetus auratus)

Cited by 12 publications

References 13 publications

Restriction of dietary protein in rats increases progressive-ratio motivation for protein

Restriction of dietary protein in rats increases progressive-ratio motivation for protein

Evaluation of Biochemical, Hematological and Parasitological Parameters of Protein-Deficient Hamsters Infected with Ancylostoma ceylanicum

Dynamic effects of dietary protein restriction on body weights, food consumption, and protein preference in C57BL/6J and Fgf21‐KO mice

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