OpenNucleome for high resolution nuclear structural and dynamical modeling
Zhuohan Lao,
Kartik Kamat,
Zhongling Jiang
et al.
Abstract:The intricate structural organization of the human nucleus is fundamental to cellular function and gene regulation. Recent advancements in experimental techniques, including high-throughput sequencing and microscopy, have provided valuable insights into nuclear organization. Computational modeling has played significant roles in interpreting experimental observations by reconstructing high-resolution structural ensembles and uncovering organization principles. However, the absence of standardized modeling tool… Show more
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