Opening of K_ATP Channel Regulates Tonic Currents From Pyramidal Neurons in Rat Brain

Abstract

These findings suggest that activation of KATP channels with DIZ regulates GABAergic transmission in neocortical pyramidal cells during development.

Anticonvulsant effects of ivermectin on pentylenetetrazole- and maximal electroshock-induced seizures in mice: the role of GABAergic system and KATP channels

“…K ATP channels are inwardly-rectifying potassium channels broadly expressed throughout the body [ 67 ]. Adenine nucleotides regulate K ATP , characteristically activated by decreasing ATP and increasing ADP levels.…”

Potassium Channels in Parkinson’s Disease: Potential Roles in Its Pathogenesis and Innovative Molecular Targets for Treatment

“…K ATP has been reported to be involved in GABA modulation in the SN (Amalric et al, 1992;Maneuf et al, 1996a). Inhibition of K ATP in the absence of glucose increased GABA release in the hippocampus (Margaill et al, 1992), whereas K ATP activation by diazoxide decreased GABA levels in the ventromedial hypothalamus (Li et al, 2017). In PD, Maneuf et al…”

Envisioning the role of inwardly rectifying potassium (Kir) channel in epilepsy

“…K ATP channels expressed predominantly in GABAergic neurons are activated through ATP depletion and anoxia, leading to decreased GABA release (Amoroso et al., 1990). Activation of K ATP channels decreased GABA A receptor‐mediated inhibitory tonic current in neonates while increased inhibitory tonic current in pyramidal neurons of adult rats (Z. Li et al., 2017). In this context, K ATP channels may provide tonic inhibition‐mediated control of neuronal excitability by affecting GABA release.…”