Open-Source Library of Tissue Engineering Scaffolds

Cendrero, Adrián Martínez; Martínez, Francisco Franco; Requejo, William Solórzano; Lantada, Andrés Díaz

doi:10.2139/ssrn.4166571

Cited by 1 publication

(1 citation statement)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Regarding mechanical properties, the ne-tuning of properties to match those from the repaired constructs should be further studied. To this end, the employment of open-source digital libraries of lattices documented with design maps [33], together with design methodologies like those from Ashby [34] for materials selection in mechanical design or from Egan for tissue engineering scaffolds [35], constitute remarkable approaches. Once the most adequate combinations of materials and lattices for the regions of interest are selected, conformal lattice design procedures could apply, as a complement to the Boolean tools used in this study.…”

Section: Main Limitations Of the Studymentioning

confidence: 99%

Engineering Design-controlled Interwoven Multimaterial Scaffolds Combining Hard and Soft Phases

Cendrero

Dehne

Sittinger

et al. 2023

Preprint

View full text Add to dashboard Cite

The graded nature of human tissues asks for functional scaffolds with gradients of properties capable of biomimetically repairing injured or deteriorated tissues. These functionally graded tissue engineering scaffolds are of special relevance for promoting the personalized treatment of articular pathologies and osteochondral defects and, despite the multiple research directions explored, no solution is yet perfect. In this study an innovative approach for engineering design-controlled and functionally graded scaffolds is presented. It stands out for combining hard-phase 3D printed lattices and soft-phase PDMS sponges or networks. The developed procedure is illustrated through two case studies: one dealing with the creation of PDMS and PDMS-PLA constructs, as chondral and osteochondral plugs; another focused on the prototyping of personalized PDMS-PLA/resin constructs, as scaffolds for the tissue engineering or repair of the meniscus. Promising potentials for the tissue engineering of complex-shaped and large-size osteochondral and meniscal defects are discussed, and a systematic description of future research directions is included.

show abstract

Section: Main Limitations Of the Studymentioning

confidence: 99%