Although I agree with most of the great review by Brandes and Tackett (1) about the connection between neuroticism and psychopathology as conceptualized in the Hierarchical Taxonomy of Psychopathology (HiTOP), there are several limitations and future research directions on which I wish to elaborate. First, and most fundamental, I welcome the aims of the HiTOP model to overcome some limitations of categorical diagnostic systems (2). However, the HiTOP frequency-approach remains largely similar to the Diagnostic and Statistical Manual of Mental Disorders [DSM-5, (3)] insofar that it negates the time dimension and most intra-individual dynamics and developmental interconnections between the various system levels [e.g., Fisher et al.(4), Jeronimus (5), and Molenaar (6)], from emotions [over hours, e.g., Kuppens et al. (7)] to mood problems [over weeks, e.g., Wichers (8)] and interpersonal and personality processes [over months and years, e.g., Hopwood (9) and Mobbs (10)], their co-development [e.g., Durbin and Hicks (11) and Ormel et al. (12)], underlying processes [e.g., Kunnen et al. (13)] and origins [e.g., Kendler et al. (14); or Nickels et al. (15) for some problems with the HiTOP], among others. For example, in line with the HiTOP model, Brandes and Tackett cover the time dimension only in Table 1 and on page 242. Neuroticism may be linked to the emergence of symptoms and psychopathology [(1), p. 243] but proof requires studies and manipulations that cover intra-individual changes across various time scales [e.g., Jeronimus (5) and Hamaker and Wichers (16)]. Hence, the inclusion of developmental and dynamic process-perspectives and methodology would make the HiTOP approach even more relevant and exciting. For example, the 25% of the Dutch population with the highest neuroticism scores seem to generate over 80% of all mental health costs (17), but a strictly dimensional or spectrum perspective cannot explain why many people with high neuroticism scores do not develop disorders and are healthy and happy (as illustrated in Figure 1 below) Health is a multidimensional state and in certain circumstances high levels of neuroticism can benefit health (20), such as when combined high conscientiousness [e.g., healthy neurotic; Turiano et al. (21) and Weston and Jackson (22)] or in interaction with various other personal strengths [e.g., Bos et al. (23) and Tamir et al. (24)]. Furthermore, high scores on the neuroticism facets worry and vulnerability predict longer lives (25). Future work shall show us in more detail what we can learn from healthy and happy neurotics.Another limitation is the stipulation that neuroticism is the most difficult personality dimension to measure in infants, toddlers, and children [(1), p. 239]. Others have reported that the neuroticism items in self-reported Big Five personality 1 Which also requires an explanation if neuroticism is equated to the general factor P [see Brandes and Tackett (1), p. 241].