Open partial horizontal laryngectomy for T2–T3–T4a laryngeal cancer: oncological outcomes and prognostic factors of two Italian hospitals

Vincentiis, Marco de; Greco, Antonio; Campo, Flaminia; Candelori, Francesca; Ralli, Massimo; Traglia, Mario Di; Colizza, Andrea; Cambria, Francesca; Zocchi, Jacopo; Manciocco, Valentina; Spriano, Giuseppe; Pellini, Raul

doi:10.1007/s00405-021-07238-x

Cited by 10 publications

(12 citation statements)

References 41 publications

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“…In particular, survival analysis showed that posterior T3 lesions had worse survival outcomes compared to T4a anterior cancers. Successively, other three studies confirmed that better oncological outcomes were achieved in T3 anterior tumors compared to posterior ones 13,14,26 …”

Section: Discussionmentioning

confidence: 81%

“…Citation searches did not identify other relevant articles. The final review was conducted on six studies (Table S2), published between 2012 and 2022 7,9–14 …”

Section: Resultsmentioning

confidence: 99%

“…One patient only remained dependent on enteral nutrition via gastrostomy after OPHL‐2a (overall gastrostomy‐dependence rate of 1.9%) 13 . De Vincentiis et al reported that at the end of the follow‐up in 139 patients (81.8%), feeding tubes were removed after an average of 43 days (14–180 days), and in 145 patients (84.7%) the tracheostomy was closed after an average of 39 days (18–104 days) 14 …”

Section: Discussionmentioning

confidence: 99%

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Partial laryngectomy for naïve pT3N0 laryngeal cancer: Systematic review on oncological outcomes

et al. 2022

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The first aim was to define the oncologic outcomes of open partial laryngectomy (OPL) in naïve pT3 laryngeal cancer. The second aim was to analyze the outcomes after OPL versus total laryngectomy (TL). A literature search was conducted in three databases (MEDLINE, EMBASE, and Cochrane Library) until January 2022. In 805 patients treated with OPL, 5-year OS, DSS, DFS and LFS were 80.5% (95% CI 70.6-87.6), 83.4% (95% CI 75.7-89), 77.4% (95% CI 66.3-85.7) and 77.9% (95% CI 68.7-85), respectively. Three articles compared TL versus OLP: 5-year OS, DSS and DFS risk difference were 0.100 (95% CI À0.092 to 0.291), 0.067 (95% CI À0.085 to 0.220) and 0.018 (95% CI À0.164 to 0.201) respectively. OPL for selected pT3 laryngeal cancer is able to guarantee a high percentage of oncological success. Accurate patient selection is of utmost importance to differentiate advanced disease amenable to conservative surgery.

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Section: Discussionmentioning

confidence: 81%

“…Citation searches did not identify other relevant articles. The final review was conducted on six studies (Table S2), published between 2012 and 2022 7,9–14 …”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Partial laryngectomy for naïve pT3N0 laryngeal cancer: Systematic review on oncological outcomes

et al. 2022

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“…Open partial horizontal laryngectomy (OPHL) is one of the most common surgical techniques in the conservative management of laryngeal cancers. The concept of partial and conservative laryngeal surgery was first introduced nearly 70 years ago by Alonso [ 1 ] and subsequently developed as a new surgical technique [ 2 , 3 , 4 ]. In the last few years, minimally invasive techniques for partial laryngectomy, total laryngectomy, and salvage laryngo-pharyngectomy after chemo-radiotherapy have been described [ 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…The concept of partial and conservative laryngeal surgery was first introduced nearly 70 years ago by Alonso [ 1 ] and subsequently developed as a new surgical technique [ 2 , 3 , 4 ]. In the last few years, minimally invasive techniques for partial laryngectomy, total laryngectomy, and salvage laryngo-pharyngectomy after chemo-radiotherapy have been described [ 4 , 5 , 6 ]. These mini-invasive approaches aim to preserve, as much as possible, the healthy tissues surrounding the larynx.…”

Section: Introductionmentioning

confidence: 99%

Outcomes of Laryngeal Cancer Surgery after Open Partial Horizontal Laryngectomies with Lateral Cervical Approach

Colizza

Ralli

Stadio

et al. 2022

JCM

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Background: Open partial horizontal laryngectomies (OPHL) are one of the surgical techniques used for the conservative management of laryngeal cancers. The aims of this study are to analyze the oncological and functional results of a group of patients affected by laryngeal squamous cell carcinoma (LSCC) treated with OPHL, performed using a minimally invasive technique. Methods: This is a prospective case–control study. We enrolled 17 consecutive patients with LSCC treated with OPHL through a lateral cervical approach (LCA). Patients were evaluated using their Penetration Aspiration Scale score (liquid, semiliquid and solid) and Voice Handicap Index (VHI) at three different endpoints: 15 days (T1), 3 months (T2), and 6 months (T2) after surgery. Results: The functional outcomes of the LCA are stackable with that of the classical anterior cervical approach in terms of respiration, swallowing, and speech. One-way ANOVA was performed to evaluate the variances of PAS and VHI scores at the three different observation points. No statistically significant differences were observed between OPHL- PAS scores for liquid (p = 0.1) at the three different observation points. A statistically significant improvement was observed in the OPHL- PAS score for semisolids and solids (p < 0.00001) between T1 and T3 (p = 0.0001) and for solids between T2 and T3 (p < 0.00001). The improvement of VHI-10 was statistically significative (p < 0.00001) at the three different observation points (T1–T2 and T2–T3). Conclusion: The LCA is a potential approach for laryngeal surgery in selected cases. The preoperative staging and planning are of the utmost importance to ensure oncological radicality. The main advantage of this approach is the preservation of the healthy tissues surrounding the larynx and the functional and oncological outcomes are stackable with the classic anterior cervical approach.

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Prognostic analysis of surgical treatment for T3 glottic laryngeal cancer based on different tumor extension patterns

Ling,

Hu,

Wang

et al. 2023

Eur Arch Otorhinolaryngol

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Open partial horizontal laryngectomy for T2–T3–T4a laryngeal cancer: oncological outcomes and prognostic factors of two Italian hospitals

Cited by 10 publications

References 41 publications

Partial laryngectomy for naïve pT3N0 laryngeal cancer: Systematic review on oncological outcomes

Partial laryngectomy for naïve pT3N0 laryngeal cancer: Systematic review on oncological outcomes

Outcomes of Laryngeal Cancer Surgery after Open Partial Horizontal Laryngectomies with Lateral Cervical Approach

Prognostic analysis of surgical treatment for T3 glottic laryngeal cancer based on different tumor extension patterns

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