Open-Lung Biopsy in Diffuse Pulmonary Disease

Gaensler, Edward A.; Moister, M. Virginia Ball; Hamm, J

doi:10.1056/nejm196406182702501

Cited by 116 publications

(21 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[7,8,25,27] In recent studies, the site of biopsy has been reported to have no influence on the diagnosis rate (Table 4). [9,10,19,21,28] Similarly, in this study, we found that the site of biopsy does not affect the diagnosis rate. We believe that it is important to evaluate radiological involvement in the selection of the appropriate segment.…”

Section: Discussionsupporting

confidence: 67%

Surgical lung biopsy for differential diagnosis of interstitial lung disease

Sevim¹

2016

Turk Gogus Kalp Dama

View full text Add to dashboard Cite

So nuç: Cerrahi akciğer biyopsileri, düşük olasılıkla da olsa, morbidite ve mortalite ile ilişkilidir. Tüm işlemlerde spesifik tanıya ulaşılamamaktadır. Cerrahi biyopsinin yeri, tipi ve sayısı tanı oranını anlamlı olarak etkilememektedir.Anah tar söz cük ler: İdyopatik interstisyel pnömoni; idyopatik pulmoner fibrozis; nonspesifik interstisyel pnömoni. ABSTRACTBackground: This study aims to investigate the diagnostic yield of surgical lung biopsy for the differential diagnosis of interstitial lung disease and the factors affecting diagnosis.

show abstract

Section: Discussionsupporting

confidence: 67%

Surgical lung biopsy for differential diagnosis of interstitial lung disease

Sevim¹

2016

Turk Gogus Kalp Dama

View full text Add to dashboard Cite

show abstract

“…At autopsy, the stiff and fibrotic lung showed no tendency to close over the needle tract. Other reports have indicated that direct visualization of the pulmonary parenchyma at thoracotomy results in a lower morbidity and mortality than needle biopsy [99]. The gross pathological finding of a stiff, noncollapsing parenchyma suggests that tissue should be obtained under direct visualization to avoid this complication.…”

Section: Demonstration Of the Organismmentioning

confidence: 99%

“…The second problem confronting the investigator is the similarity between the symptoms and signs of Ptzeurtlog~.sfis cnrirtii pneumonitis and other diseases characterized by pulmonary interstitial fibrosis [81,85,88,99,185, case 51. Case number five, diagnosed as interstitial pneumonitis of infancy, was clinically indistinguishable from Pt~eunzogstis carinii pneumonitis.…”

Section: Cburse Arid Proxnosi~mentioning

confidence: 99%

Pneumocystis Carinii Pneumonitis A Review

Robbins

1967

Pediatr Res

View full text Add to dashboard Cite

“…The interstitial lung disorders are a group of chronic inflammatory disorders of the lower respiratory tract in which the normal alveolar walls are progressively thickened by a fibrotic process characterized by an expansion of fibroblast numbers and a collagenous extracellular matrix secreted by these cells (1)(2)(3). Since fibrosis of the alveolar wall is generally an irreversible process, an understanding of the mechanisms modulating the fibrotic state is necessary in order to understand the pathogenesis of these disorders and to develop a therapeutic strategy to prevent the irreversible loss of alveolar-capillary units.…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of pulmonary fibrosis. Spontaneous release of the alveolar macrophage-derived growth factor in the interstitial lung disorders.

Bitterman¹,

Adelberg²,

Crystal³

1983

J. Clin. Invest.

185

View full text Add to dashboard Cite

A B S T R A C T Interstitial lung disorders are characterized both by a chronic inflammation of the lower respiratory tract that includes increased numbers of activated alveolar macrophages and by increased numbers of fibroblasts within the alveolar wall. Since alveolar macrophages from normal individuals can be activated to release a growth factor for lung fibroblasts (alveolar macrophage-derived growth factor [AMDGF]), we hypothesized that the activated alveolar macrophages within the lower respiratory tract of patients with fibrotic lung disorders might be spontaneously releasing AMDGF. To evaluate this hypothesis, alveolar macrophages (suspension culture, 4 h, 370) from 65 patients with interstitial lung disorders and 30 control subjects were examined for the spontaneous release of fibroblast growth-promoting activity, with human lung fibroblasts as the target. Whereas none of the controls had macrophages spontaneously releasing a growth-promoting activity for fibroblasts, 82% of the patients with interstitial lung disease had alveolar macrophages that were spontaneously releasing a growthpromoting activity for fibroblasts. In common with AMDGF, the fibroblast growth-promoting activity released by these macrophages eluted from DEAE cellulose at 270 mM NaCl, had a partition coefficient of 0.3 by gel filtration on Sephadex G-50, was distinct from other characterized growth factors, and acted as a progression factor for fibroblast replication in a serumfree complementation test. These data suggest that the expansion of fibroblast numbers within the alveolar structures in interstitial lung disorders may result, in part, from the release of AMDGF by alveolar macrophages stimulated in vivo.

show abstract

Open-Lung Biopsy in Diffuse Pulmonary Disease

Cited by 116 publications

References 16 publications

Surgical lung biopsy for differential diagnosis of interstitial lung disease

Surgical lung biopsy for differential diagnosis of interstitial lung disease

Pneumocystis Carinii Pneumonitis A Review

Mechanisms of pulmonary fibrosis. Spontaneous release of the alveolar macrophage-derived growth factor in the interstitial lung disorders.

Contact Info

Product

Resources

About