Open-Lung Biopsy

Trummer, Max J.; Sher, Melvin H.; Arnold, Homer S.

doi:10.1001/archsurg.1967.01330130122024

Cited by 1 publication

(3 citation statements)

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“…Lung biopsies are performed to ascertain an accurate diagnosis of the onset of interstitial lung disease or confirm the absence/presence of cancer. Various lung biopsy procedures include needle, thoracoscopic, transbronchial, and open biopsy 117,118 . Many studies have utilized airway and lung tissues obtained by a biopsy to study the pathogenesis and effects of treatments in the context of asthma, COPD, lung fibrosis, and cancer 92,119–121 …”

Section: Lung Biopsies and Tissues In Respiratory Researchmentioning

confidence: 99%

“…Various lung biopsy procedures include needle, thoracoscopic, transbronchial, and open biopsy. 117,118 Many studies have utilized airway and lung tissues obtained by a biopsy to study the pathogenesis and effects of treatments in the context of asthma, COPD, lung fibrosis, and cancer. 92,[119][120][121] Airway and lung biopsies contain all of the cell and tissue compartments affected by respiratory diseases, including the airways and the lung parenchyma.…”

Section: Lung Biopsies and Tissues In Respiratory Researchmentioning

confidence: 99%

Section: Lung Biopsies and Tissues In Respiratory Researchmentioning

confidence: 99%

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Advanced models for respiratory disease and drug studies

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et al. 2023

Medicinal Research Reviews

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The global burden of respiratory diseases is enormous, with many millions of people suffering and dying prematurely every year. The global COVID‐19 pandemic witnessed recently, along with increased air pollution and wildfire events, increases the urgency of identifying the most effective therapeutic measures to combat these diseases even further. Despite increasing expenditure and extensive collaborative efforts to identify and develop the most effective and safe treatments, the failure rates of drugs evaluated in human clinical trials are high. To reverse these trends and minimize the cost of drug development, ineffective drug candidates must be eliminated as early as possible by employing new, efficient, and accurate preclinical screening approaches. Animal models have been the mainstay of pulmonary research as they recapitulate the complex physiological processes, Multiorgan interplay, disease phenotypes of disease, and the pharmacokinetic behavior of drugs. Recently, the use of advanced culture technologies such as organoids and lung‐on‐a‐chip models has gained increasing attention because of their potential to reproduce human diseased states and physiology, with clinically relevant responses to drugs and toxins. This review provides an overview of different animal models for studying respiratory diseases and evaluating drugs. We also highlight recent progress in cell culture technologies to advance integrated models and discuss current challenges and present future perspectives.

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Section: Lung Biopsies and Tissues In Respiratory Researchmentioning

confidence: 99%