Open Label Trial of Coenzyme Q10 as A Migraine Preventive

Rozen, TD; Oshinsky, Michael L.; Gebeline, CA; Bradley, KC; Young, WB; Shechter, A. L.; Silberstein, SD

doi:10.1046/j.1468-2982.2002.00335.x

Cited by 148 publications

(85 citation statements)

References 15 publications

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“…One possible mechanism of increased stroke risk may be oxidative stress, which has been theorized to have a role in migraine and may lead to increased susceptibility to vascular events among active smokers. 27 Second, smoking is a known risk factor for atherosclerosis; although increased arterial stiffness, carotid intima-media thickness, and impaired endothelial-dependent vasoreactivity have been associated with migraine, an increased association between atherosclerosis and migraine is not evident. 28,29 Finally, prothrombotic states, decreased platelet hemostasis time, and endothelial dysfunction associated with migraine are all plausible mechanisms for which stroke risk may be enhanced in active smokers.…”

Section: Resultsmentioning

confidence: 99%

Migraine and risk of stroke in older adults

et al. 2015

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Objective: To examine the association between migraine and stroke/vascular outcomes in a racially/ethnically diverse, older cohort.Methods: Participants from the Northern Manhattan Study, a population-based cohort study of stroke incidence, were assessed for migraine symptoms using a self-report questionnaire based on criteria from the International Classification of Headache Disorders, second edition. We estimated the association between migraine and combined vascular events including stroke and stroke only over a mean follow-up of 11 years, using Cox models adjusted for sociodemographic and vascular risk factors.Results: Of 1,292 participants (mean age 68 6 9 years) with migraine data followed prospectively for vascular events, 262 patients (20%) had migraine and 75 (6%) had migraine with aura. No association was found between migraine (with or without aura) and risk of either stroke or combined cardiovascular events. There was an interaction between migraine and current smoking (p 5 0.02 in relation to stroke and p 5 0.03 for combined vascular events), such that those with migraine and smoking were at an increased risk. The hazard ratio of stroke for migraine among current smokers was 3.17 (95% confidence interval [CI] 1.13-8.85) and among current nonsmokers was 0.77 (95% CI 0.44-1.35). In relation to combined vascular events, the hazard ratio for migraine vs no migraine among current smokers was 1.83 (95% CI 0.89-3.75) and among current nonsmokers was 0.63 (95% CI 0.43-0.94). Conclusion:In our racially/ethnically diverse population-based cohort, migraine was associated with an increased risk of stroke among active smokers but not among nonsmokers. Migraine is a complex neurovascular syndrome resulting in an unstable trigeminal vascular system. It has been suggested that migraine and stroke exist on a continuum, and the vascular system may have important secondary consequences in migraine.1 While the vascular theory of migraine has been disproved, migraine with aura, mostly in women younger than 45 years, has been shown to be an independent risk factor for ischemic stroke.2 Some studies also suggest that migraine is associated with an unfavorable cardiovascular risk profile, cardiovascular disease events, and vascular death.3-8 However, there are no reliable indicators to predict which migraineurs will develop cerebrovascular ischemic insults and other vascular events. Moreover, migraine may be a potentially modifiable vascular risk factor, requiring further exploration in high-risk populations.The objective of this study was to assess the association between migraine, including both migraine with and without aura, and stroke in the Northern Manhattan Study (NOMAS), an ethnically diverse, older, community-based cohort. As a secondary aim, we also explored the association between migraine and vascular events/mortality.

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Section: Resultsmentioning

confidence: 99%

Migraine and risk of stroke in older adults

et al. 2015

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“…ATP was found to be reduced in the occipital lobe of MwoA patients, however, ATP remains to be measured in MwA patients. Additional evidence supporting a disturbed energy metabolism in migraine, comes from pharmacological studies showing the effects of metabolic enhancers, such as riboflavin and coenzyme Q10 (both with a well defined role in mitochondrial membrane generation of ATP), in migraine prophylaxis (65)(66)(67)(68). It is worthy of note that the therapeutic response to riboflavin was associated with specific mitochondrial DNA haplogroups (69).…”

Section: Functional Paradigmmentioning

confidence: 99%

Magnetic resonance spectroscopy in migraine: What have we learned so far?

2012

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Objective: To summarize and evaluate proton (1H) and phosphorus (31P) magnetic resonance spectroscopy (MRS) findings in migraine. Methods: A thorough review of 1H and/or 31P-MRS studies in any form of migraine published up to September 2011. Results: Some findings were consistent in all studies, such as a lack of ictal/interictal brain pH change and a disturbed energy metabolism, the latter of which is reflected in a drop in phosphocreatine content, both in the resting brain and in muscle following exercise. In a recent interictal study ATP was found to be significantly decreased in the occipital lobe of migraine with aura patients, reinforcing the concept of a mitochondrial component to the migraine threshold, at least in a subgroup of patients. In several studies a correlation between the extent of the energy disturbance and the clinical phenotype severity was apparent. Less consistent but still congruent with a disturbed energy metabolism is an observed lactate increase in the occipital cortex of several migraine subtypes (MwA, migraine with prolonged aura). No increases in brain glutamate levels were found. Conclusion: The combined abnormalities found in MRS studies imply a mitochondrial component in migraine neurobiology. This could be due to a primary mitochondrial dysfunction or be secondary to, for example, alterations in brain excitability. The extent of variation in the data can be attributed to both the variable clinical inclusion criteria used and the variation in applied methodology. Therefore it is necessary to continue to optimize MRS methodology to gain further insights, especially concerning lactate and glutamate.

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“…Çalışmanın sonuçlarına göre migren proflaksisinin koenzim Q10 kullanımı ile düzeltilebileceği düşü-nülmektedir. 53 Benzer bir şekilde, Shoeibi ve ark. çalışmasında da koenzim Q 10 kullanan grubun aylık başağrı sıklığında ve süresinde azalma bulunmuştur.…”

Section: Ri̇boflavi̇n Koenzi̇m Q10 Ve Mi̇grenunclassified

The Relationship Between Frequency, Duration and Intensity of Migraine Attacks and Nutrition

Oğuz¹,

Güneş²,

Öğren³

2018

Turkiye Klinikleri J Health Sci

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Ö ÖZ ZE ET T Migren normal duyusal olayların anormal beyin işlemesi nedeniyle sinir sisteminin aşırı duyarlı olması sonucu oluşan poligenetik bir hastalıktır. Dünya Sağlık Örgütü (DSÖ) yaşam şartlarını etkileyen en engelleyici kronik hastalıklarından biri olarak migreni görmektedir. Beslenme, hormonal ve çevresel faktörler duyarlı bireylerde migreni tetikleyebilir. Stres, hormonal değişiklikler, psikolojik yönler, yorgunluk, uyku süresinde dengesizlikler, ilaçlar ve tütün kullanımı, kokulara hassasiyet, egzersiz, ışık, iklim değişikliği ve yüksek rakım migreni artıran faktörlerdir. Migren ve beslenme arasında karmaşık bir ilişki mevcuttur. Besinsel tetikleyici faktörler halen tartışmalı bir konudur ve değerlendirilmesi bireysel farklılıklar nedeniyle oldukça zordur. Genel olarak açlık veya öğün atlama ciddi bir tetikleyici olmakla beraber çikolata, kırmızı şarap, peynir, kafein, monosodyum glutamat (MSG), nitrit ve aspartam önemli tetikleyiciler olarak karşımıza çıkmaktadır. Yapılan yeni çalışmalarda migren tedavisinde ek olarak magnezyum, riboflavin, koenzim Q10 gibi bazı fonksiyonel besinlerin kullanımının migren ataklarının sıklığını, şiddetini ve süresini azaltıla-bileceği bulunmuştur. Migrenin alerji ile ilişkili olduğu düşünülerek, alerji oluşturan besinlerin diyetten çıkarılmasını kapsayan eliminasyon diyetleri gündeme gelmiştir. Beden Kitle İndeksi (BKİ) ve migren özellikleri arasındaki ilişki çelişkili olmasına rağmen çok zayıf ve kilolu olmanın migren nöbetlerini tetikleyebileceğini gösteren bazı çalışmalar mevcuttur. Bu çalışmanın amacı, yapılmış güncel çalışmalar ışığında migreni tetikleyen besinler ve bu besinler ile migren nöbetlerinin şiddeti, yoğunluğu ve süresi arasındaki ilişkileri incelemektir.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Migren hastalığı; beslenme tedavisi

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Open Label Trial of Coenzyme Q10 as A Migraine Preventive

Cited by 148 publications

References 15 publications

Migraine and risk of stroke in older adults

Migraine and risk of stroke in older adults

Magnetic resonance spectroscopy in migraine: What have we learned so far?

The Relationship Between Frequency, Duration and Intensity of Migraine Attacks and Nutrition

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