2002
DOI: 10.1046/j.1468-2982.2002.00335.x
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Open Label Trial of Coenzyme Q10 as A Migraine Preventive

Abstract: The objective was to assess the efficacy of coenzyme Q10 as a preventive treatment for migraine headaches. Thirty-two patients (26 women, 6 men) with a history of episodic migraine with or without aura were treated with coenzyme Q10 at a dose of 150 mg per day. Thirty-one of 32 patients completed the study; 61.3% of patients had a greater than 50% reduction in number of days with migraine headache. The average number of days with migraine during the baseline period was 7.34 and this decreased to 2.95 after 3 m… Show more

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Cited by 154 publications
(91 citation statements)
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“…One possible mechanism of increased stroke risk may be oxidative stress, which has been theorized to have a role in migraine and may lead to increased susceptibility to vascular events among active smokers. 27 Second, smoking is a known risk factor for atherosclerosis; although increased arterial stiffness, carotid intima-media thickness, and impaired endothelial-dependent vasoreactivity have been associated with migraine, an increased association between atherosclerosis and migraine is not evident. 28,29 Finally, prothrombotic states, decreased platelet hemostasis time, and endothelial dysfunction associated with migraine are all plausible mechanisms for which stroke risk may be enhanced in active smokers.…”
Section: Resultsmentioning
confidence: 99%
“…One possible mechanism of increased stroke risk may be oxidative stress, which has been theorized to have a role in migraine and may lead to increased susceptibility to vascular events among active smokers. 27 Second, smoking is a known risk factor for atherosclerosis; although increased arterial stiffness, carotid intima-media thickness, and impaired endothelial-dependent vasoreactivity have been associated with migraine, an increased association between atherosclerosis and migraine is not evident. 28,29 Finally, prothrombotic states, decreased platelet hemostasis time, and endothelial dysfunction associated with migraine are all plausible mechanisms for which stroke risk may be enhanced in active smokers.…”
Section: Resultsmentioning
confidence: 99%
“…ATP was found to be reduced in the occipital lobe of MwoA patients, however, ATP remains to be measured in MwA patients. Additional evidence supporting a disturbed energy metabolism in migraine, comes from pharmacological studies showing the effects of metabolic enhancers, such as riboflavin and coenzyme Q10 (both with a well defined role in mitochondrial membrane generation of ATP), in migraine prophylaxis (65)(66)(67)(68). It is worthy of note that the therapeutic response to riboflavin was associated with specific mitochondrial DNA haplogroups (69).…”
Section: Functional Paradigmmentioning
confidence: 99%
“…Çalışmanın sonuçlarına göre migren proflaksisinin koenzim Q10 kullanımı ile düzeltilebileceği düşü-nülmektedir. 53 Benzer bir şekilde, Shoeibi ve ark. çalışmasında da koenzim Q 10 kullanan grubun aylık başağrı sıklığında ve süresinde azalma bulunmuştur.…”
Section: Ri̇boflavi̇n Koenzi̇m Q10 Ve Mi̇grenunclassified