Open Label Clinical Trial of Hydrogen Brain Food for 91 Alzheimer's Patients (Targeting Therapy for Homocysteic Acid in Blood is an Alzheimer's Cognitive Recovery)

Abstract

Introduction: Exercise and antioxidant nutrition based food are good prevention for Alzheimer's Disease. But why are these preventions effective to prevent AD? Recent our findings that human AD patients could not excrete homocysteic acid (HA) into urine and their blood HA was a good marker for the cognitive decline in AD, which indicated that the treatment for HA in blood can be a good therapy for the recovery of cognitive decline of AD. Methods:We have developed new food supplement which can compete with HA and also reduce the sulfite group of HA. We named this supplement as HBF. We observed the effect of HBF on 91 AD patients as an open labeled clinical trial. Results:In fact we have developed the brain food which can decrease HA in blood. And we have observed that the open-labeled clinical trial of HBF (hydrogen brain food) for 91 AD patients was good positive results. Even the final stage of AD patients, their cognitive behavior was surprisingly recovered.Discussions: From our observations, it is suggested that targeting homocysteic acid in blood is a good therapy for the cognitive recovery of AD and also suggested that exercise and antioxidant nutrition food also can decrease HA in blood partially and these methods are good preventions for AD, because normal person's HA level in blood is very low. Open Label Clinical Trial of Hydrogen Research ArticleOpen Access IntroductionPeople thinks that Alzheimer's disease (AD) is a fatal disease and if someone became AD, his or her life will be end. There is no hope for AD. Is it a true? Why does people think so? Our scientific efforts could not succeed to clarify the true AD pathogen. At present amyloid hypothesis [1] is still strong power in AD field. However this hypothesis could not succeed to recover the AD cognitive impairment. Why? Many scientists think that the amyloid treatment was too late for AD patients whose neuronal damage was proceeding and amyloid treatment could not stop these damage. Is it a true? If amyloid is a true pathogen, the neuronal damage can be stopped and their cognitive ability can be recovered or can be stopped to decline.There is a nun study [2]. From this research we have noticed that there was a big discrepancy between the pathological AD change and the brain cognitive activity. For example, sister Mary's observation. She was very active cognition in her later life, but after her death, her brain showed the typical AD brain. Why did she show so active cognition even in her AD brain? Yes, we say that her brain showed the cognitive reserve ability [3]. From these studies, we have some ideas that if we can decrease the true pathogen, we can bring back AD brain to some recovered cognitive abilities and their brains can show some cognitive reserve abilities. We have developed some brain food which could decrease HA in blood. 91 patients took this supplement for 2 months and their cognitive behaviors were measured with NM scale and we have observed the strong recovery of all patients (100%) and even final stage of AD patients show...