Open globe injuries with positive intraocular cultures

Lieb, Douglas F.; Scott, Ingrid U.; Flynn, Harry W.; Miller, Darlene; Feuer, William J.

doi:10.1016/s0161-6420(03)00497-4

Cited by 96 publications

(16 citation statements)

References 21 publications

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“… 102 Recent studies have reported that a final visual acuity of 20/40 or better was achieved in only 15%–40% of cases with posttraumatic endophthalmitis. 95 , 98 , 164 , 165 One series reported that a good final visual outcome (defined as 20/45 or better) was significantly associated with initial visual acuity of at least LP and an absence of a pupillary fibrin membrane. 165 …”

Section: Visual Outcomes Of Endophthalmitis Treatmentmentioning

confidence: 99%

Endophthalmitis: state of the art

Vaziri¹,

Schwartz²,

Kishor³

et al. 2015

OPTH

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Endophthalmitis is an uncommon diagnosis but can have devastating visual outcomes. Endophthalmitis may be endogenous or exogenous. Exogenous endophthalmitis is caused by introduction of pathogens through mechanisms such as ocular surgery, open-globe trauma, and intravitreal injections. Endogenous endophthalmitis occurs as a result of hematogenous spread of bacteria or fungi into the eye. These categories of endophthalmitis have different risk factors and causative pathogens, and thus require different diagnostic, prevention, and treatment strategies. Novel diagnostic techniques such as real-time polymerase chain reaction (RT-PCR) have been reported to provide improved diagnostic results over traditional culture techniques and may have a more expanded role in the future. While the role of povidone-iodine in prophylaxis of postoperative endophthalmitis is established, there remains controversy with regard to the effectiveness of other measures, including prophylactic antibiotics. The Endophthalmitis Vitrectomy Study (EVS) has provided us with valuable treatment guidelines. However, these guidelines cannot be directly applied to all categories of endophthalmitis, highlighting the need for continued research into attaining improved treatment outcomes.

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Section: Visual Outcomes Of Endophthalmitis Treatmentmentioning

confidence: 99%

Endophthalmitis: state of the art

Vaziri¹,

Schwartz²,

Kishor³

et al. 2015

OPTH

View full text Add to dashboard Cite

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“…However, with an IOFB resulting from an explosion, as well as in trauma involving vegetable matter in rural settings, the possibility of infection is up to 30% (Al-Mezaine et al, 2010). In these cases, bacteria such as Bacillus cereus, Staphylococcus aureus, Streptococcus pneumoniae, and Pseudomonas aeruginosa can lead to extremely poor visual results (Lieb et al, 2003;Al-Qmran et al, 2007). In this case, the knowledge about the composition and origin of IOFB obtained by x-ray diffraction implied a worse prognosis of the accident.…”

Section: Resultsmentioning

confidence: 99%

X-ray Diffraction Analysis to Clarify the Unusual Origin of an Intraocular Foreign Body

Ascaso¹

2012

BJMMR

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Purpose: To clarify the origin of a metallic intraocular foreign body (IOFB) due to a firecracker injury and to show the utility of X-ray diffraction analysis in the identification process. Methods: Interventional case report using X-ray diffraction technique. Results: We report a mechanism of firecracker ocular injury not previously described in the published literature. It involved penetration into the eye by a ground particle of calamine (originated from the area of detonation) and not, as it could be suspected, by a firecracker fragment. Conclusion: X-ray diffraction analysis showed environmental debris in the area of detonation can be injected as foreign material into the eye.

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“…As previously reported, the bacterial spectrum from post-traumatic endophthalmitis is relatively different from post-operative endophthalmitis. Coagulase-negative staphylococci is more prevalent in post-operative endophthalmitis (45–48%)[ 8 ] than in post-traumatic endophthalmitis (21.5%-26%) [ 26 – 28 ]. However, the prevalence of Gram-negative bacillus (15.7%-18.5%) is higher in post-traumatic endophthalmitis [ 26 – 28 ], which is commonly associated with poorer visual prognosis.…”

Section: Discussionmentioning

confidence: 99%

“…Coagulase-negative staphylococci is more prevalent in post-operative endophthalmitis (45–48%)[ 8 ] than in post-traumatic endophthalmitis (21.5%-26%) [ 26 – 28 ]. However, the prevalence of Gram-negative bacillus (15.7%-18.5%) is higher in post-traumatic endophthalmitis [ 26 – 28 ], which is commonly associated with poorer visual prognosis. [ 29 ] Despite these findings, coagulase-negative staphylococci is still the most common pathogen in post-traumatic endophthalmitis.…”

Section: Discussionmentioning

confidence: 99%

Survey of Intraocular Antibiotics Prophylaxis Practice after Open Globe Injury in China

et al. 2016

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PurposeTo elucidate the Chinese practice of intraocular antibiotics administration for prophylaxis after open globe injury.MethodsA cross-sectional questionnaire survey was performed online by scanning a Quickmark (QR) code with smartphones at the 20th Chinese National Conference of Ocular Trauma in November 2014.ResultsA total of 153 (30.6%) of all participators at the conference responded. Of the respondents, 20.9% were routinely administered with prophylactic intraocular injection of antibiotics at the conclusion of the primary eye repair, and 56.9% were used only in cases with high risk of endophthalmitis development. The intraocular route of delivery was mainly included with intracameral injection (47.9%) and intravitreal injection (42.0%). Cephalosporins (53.8%) and vancomycin (42.0%) were the main choices of antibiotic agents, followed by fluoroquinolones (24.3%), and aminoglycosides (13.4%). Only 21.9% preferred a combination of two or more two drugs routinely. In addition, significantly more respondents from the referral eye hospital (92.7%) replied using intraocular antibiotics injection for prophylaxis compared to those respondents from the primary hospital (69.4%) (p = 0.001, Fisher’s exact test).ConclusionsIntraocular antibiotics injection for post-traumatic endophthalmitis prophylaxis is widely used in China. However, the choice of antibiotic agents and the intraocular route of delivery vary. A well-designed clinical trial is needed to establish a standardized protocol of intraocular antibiotics administration for post-traumatic endophthalmitis prophylaxis.

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Open globe injuries with positive intraocular cultures

Cited by 96 publications

References 21 publications

Endophthalmitis: state of the art

Endophthalmitis: state of the art

X-ray Diffraction Analysis to Clarify the Unusual Origin of an Intraocular Foreign Body

Survey of Intraocular Antibiotics Prophylaxis Practice after Open Globe Injury in China

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