“…Certainly, to measure allodynia that reflects a better clinical condition, we used the von Frey filaments considering that after surgery, non-noxious stimuli could be the main source of evoked pain ( Jensen and Finnerup, 2014 ). Nevertheless, although evoked nociceptive tests are useful to evaluate potential analgesics drugs, the measurement of spontaneous behavior is crucial because provides insight into the pain process under “normal” environmental conditions ( Matson et al., 2007 ; Gould et al., 2009 ; Urban et al., 2011 ; Cho et al., 2013 ; Majuta et al., 2017b ; Castel et al., 2018 ). In humans, spontaneous pain can be quantified by asking them ( Gaston-Johansson et al., 1990 ), whereas in rodents the locomotor activity can be analyzed as a surrogate model of this outcome ( Roughan et al., 2009 ; Majuta et al., 2018 ).…”